ID D4ASM8_ARTBC Unreviewed; 702 AA.
AC D4ASM8;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 03-MAY-2023, entry version 52.
DE RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819, ECO:0000256|PIRNR:PIRNR017222};
DE Short=eIF-2A {ECO:0000256|PIRNR:PIRNR017222};
GN ORFNames=ARB_07243 {ECO:0000313|EMBL:EFE33778.1};
OS Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS mentagrophytes).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=663331 {ECO:0000313|EMBL:EFE33778.1, ECO:0000313|Proteomes:UP000008866};
RN [1] {ECO:0000313|Proteomes:UP000008866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4681 / CBS 112371 {ECO:0000313|Proteomes:UP000008866};
RX PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT "Comparative and functional genomics provide insights into the
RT pathogenicity of dermatophytic fungi.";
RL Genome Biol. 12:R7.1-R7.16(2011).
CC -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC number of specific mRNAs. Acts by directing the binding of methionyl-
CC tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC GTP-dependent manner. {ECO:0000256|PIRNR:PIRNR017222}.
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC {ECO:0000256|ARBA:ARBA00009573, ECO:0000256|PIRNR:PIRNR017222}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFE33778.1}.
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DR EMBL; ABSU01000008; EFE33778.1; -; Genomic_DNA.
DR RefSeq; XP_003014681.1; XM_003014635.1.
DR AlphaFoldDB; D4ASM8; -.
DR STRING; 663331.D4ASM8; -.
DR GeneID; 9527044; -.
DR KEGG; abe:ARB_07243; -.
DR eggNOG; KOG2315; Eukaryota.
DR HOGENOM; CLU_013809_0_1_1; -.
DR OMA; WNPNSKE; -.
DR OrthoDB; 22264at2759; -.
DR Proteomes; UP000008866; Unassembled WGS sequence.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR Pfam; PF08662; eIF2A; 1.
DR PIRSF; PIRSF017222; eIF2A; 2.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Reference proteome {ECO:0000313|Proteomes:UP000008866};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845,
KW ECO:0000256|PIRNR:PIRNR017222}.
FT DOMAIN 181..375
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
FT REGION 379..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 445..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..594
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..638
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 702 AA; 75812 MW; 1586E57AD7E1195E CRC64;
MAAPTQLAYL KGTSGVPHTL PVADISPGLP QKVNQIPAEN VYEIDFSPLG TYVITWQRPS
KDENGDAVRN LKVWKVATES ETQDQQTPIG SFVQKSQTGW NLQYASDEQY CARVVTNEVQ
FYESGNLGSV WKKLRVEGVA DFALSPGKGH AVATFIPERK GQPASVRIFD MPNFNAPVSQ
KSFYKGDKVQ LKWNNTGTTL IVLAQTDVDK SGKSYYGETT LYLLSVSGTF DSRIDLDKEG
PIHDVTWSPT SKEFGVVYGY MPAKTTIFNT RAVATHSFQL GPRNTILFSP HGRFVLVAGF
GNLAGQMDIY DVEKDYKKIV TIEASNASVC EWSPDGRHIL TATTSPRLRV DNGVRIWHVT
GALMYNEDMN ELYSVSWRPQ SPNSHPLTSN PLNPVPTPHP SATAYLSTKK APTKPAGAYR
PPGARGQSTP LAFRREDEGG AAFVREDSSS FASNGGSAPS PFGKPRRRAV PGAEPVEEFL
PPGAAPGGGV ALPPGAEASA PGPEKLSKSA AKNKKKREAK KAKEASAGGQ GDGGENSMAA
TPNSGRRDRS RSRHRQQASG GANGANGANL DPNYPRGGRD RSRSAHRRQR SDGRNSTPNR
NGNGNQPHDR RSPAVNTTGR QQAAPPDLTV TSPDGGNTAN AAPDAAAIAR DKKMRSLLKK
VRAIDELKMR VASGEKLEET QMKKIHTEDS VRSELEALGW TG
//
