ID D4ATQ8_ARTBC Unreviewed; 644 AA.
AC D4ATQ8;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=DNA (cytosine-5-)-methyltransferase {ECO:0000256|ARBA:ARBA00011975};
DE EC=2.1.1.37 {ECO:0000256|ARBA:ARBA00011975};
GN ORFNames=ARB_07624 {ECO:0000313|EMBL:EFE33677.1};
OS Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS mentagrophytes).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=663331 {ECO:0000313|EMBL:EFE33677.1, ECO:0000313|Proteomes:UP000008866};
RN [1] {ECO:0000313|Proteomes:UP000008866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4681 / CBS 112371 {ECO:0000313|Proteomes:UP000008866};
RX PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT "Comparative and functional genomics provide insights into the
RT pathogenicity of dermatophytic fungi.";
RL Genome Biol. 12:R7.1-R7.16(2011).
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFE33677.1}.
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DR EMBL; ABSU01000009; EFE33677.1; -; Genomic_DNA.
DR RefSeq; XP_003014317.1; XM_003014271.1.
DR AlphaFoldDB; D4ATQ8; -.
DR STRING; 663331.D4ATQ8; -.
DR GeneID; 9521737; -.
DR KEGG; abe:ARB_07624; -.
DR eggNOG; ENOG502RYYW; Eukaryota.
DR HOGENOM; CLU_012943_2_1_1; -.
DR OMA; KPRVHTM; -.
DR OrthoDB; 1948937at2759; -.
DR Proteomes; UP000008866; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10629:SF52; DNA (CYTOSINE-5)-METHYLTRANSFERASE 1; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR PRINTS; PR00105; C5METTRFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Reference proteome {ECO:0000313|Proteomes:UP000008866};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 540..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 612..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 14..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 350
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 644 AA; 71702 MW; 9905BC5478C14026 CRC64;
MAVNILPVIE LDSDHESISS SNSTIDANGY SSPASSISPS PGFRGDDFMS DTDFEAYVHS
LSGNDESPSP TPRRAKERTI PTERVLPPRT HLSEIRYQGR TYRPGKFIEL QDGTFVRVNR
ILQSSDKTVV SGPKFERLEN MGSRMPDRPN ELCWVIDQGD YSSSSSSRHS NASQYRPYSG
EVEVPLSAIR RLRIIRLTNK RYSPTLDENR DDGFLFCRMK YTRVWKRRPS VSGRGTADIV
EEKITFLLPE DCQSSLSVSR EELRNNWRGT VLHKRRYTFG DGFCGAGGVS RGAQQAGLKL
SWAFDKSESA INSYRANFPS CLAEHSEVAQ FLTSLPRELL VDVMHVSPPC QPFSPAKTIA
AAHDEANEAC LFSIYRLIEL CKPRVATMEQ TSGLKQRHPI WLDAIIHSLI ELGYSVRWRL
VNCKDYGVPQ SRCRLILIAA GPGEELPPFP QPTHGDEPGK LPLVTILDAI SGIPSTAPDH
DLERAERPFE RRPYDPRSLA RTLTCSGGDN FHPSGTRTFT LREAASLQTF PLNHTFCAPV
LVVLPILCSC VVILIVLIIA ALVHLISILS DLITSASASA VSHLCQLTSA ILGPTPPNLL
FSSLQLQLRN FLFLPSFLLL SSLVSSLPRP FFFQKEVVDS FLQR
//
