ID D4ATS8_ARTBC Unreviewed; 313 AA.
AC D4ATS8;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 13-SEP-2023, entry version 42.
DE RecName: Full=Mitochondrial pyruvate carrier {ECO:0000256|RuleBase:RU363100};
GN ORFNames=ARB_07644 {ECO:0000313|EMBL:EFE33697.1};
OS Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS mentagrophytes).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=663331 {ECO:0000313|EMBL:EFE33697.1, ECO:0000313|Proteomes:UP000008866};
RN [1] {ECO:0000313|Proteomes:UP000008866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4681 / CBS 112371 {ECO:0000313|Proteomes:UP000008866};
RX PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT "Comparative and functional genomics provide insights into the
RT pathogenicity of dermatophytic fungi.";
RL Genome Biol. 12:R7.1-R7.16(2011).
CC -!- FUNCTION: Mediates the uptake of pyruvate into mitochondria.
CC {ECO:0000256|RuleBase:RU363100}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448,
CC ECO:0000256|RuleBase:RU363100}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU363100}.
CC -!- SIMILARITY: Belongs to the mitochondrial pyruvate carrier (MPC) (TC
CC 2.A.105) family. {ECO:0000256|ARBA:ARBA00006416,
CC ECO:0000256|RuleBase:RU363100}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFE33697.1}.
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DR EMBL; ABSU01000009; EFE33697.1; -; Genomic_DNA.
DR RefSeq; XP_003014337.1; XM_003014291.1.
DR AlphaFoldDB; D4ATS8; -.
DR STRING; 663331.D4ATS8; -.
DR GeneID; 9521757; -.
DR KEGG; abe:ARB_07644; -.
DR eggNOG; KOG1589; Eukaryota.
DR HOGENOM; CLU_1020109_0_0_1; -.
DR OrthoDB; 590256at2759; -.
DR Proteomes; UP000008866; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006850; P:mitochondrial pyruvate transmembrane transport; IEA:InterPro.
DR InterPro; IPR005336; MPC.
DR Pfam; PF03650; MPC; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363100};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW ECO:0000256|RuleBase:RU363100};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792,
KW ECO:0000256|RuleBase:RU363100};
KW Reference proteome {ECO:0000313|Proteomes:UP000008866};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363100};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363100};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363100}.
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363100"
FT TRANSMEM 253..275
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363100"
SQ SEQUENCE 313 AA; 35020 MW; 7989E69BDA161DD5 CRC64;
MVAAIQTVPP LVRKGLVRRK ESVSKPQLSV SACRRRRFAA SFSMFDVQKS RLILRKPEEE
RKIAELLSCK KDDEEDEDDD DDDDEERRRG LGLGLGPGLW GLAFSFFPFG CVLYLVSLGS
KGRFVSRFSL SSRYTTNYRQ HVVEDRAASL PELQGCLSEC HCSLQGAGSP GPTIPEHRRR
CGPAELPAAV MEQSHWHQDR PFLWIPLQWI LVLAGLSDMA RPAEKLSLTQ NAALMATGAI
WTRWCLIIKP RNVLLATVNF FVGCVGFTQV TRIFLYRRSQ DGSAKEAVKD LAHEATDSAK
AAVHKAEEAV KKH
//
