ID D4AUP9_ARTBC Unreviewed; 2588 AA.
AC D4AUP9;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=Non-reducing polyketide synthase nscA {ECO:0000256|ARBA:ARBA00018393};
DE AltName: Full=Conidial yellow pigment biosynthesis polyketide synthase nscA {ECO:0000256|ARBA:ARBA00031359};
DE AltName: Full=Neosartoricin B biosynthesis protein A {ECO:0000256|ARBA:ARBA00033379};
GN ORFNames=ARB_07966 {ECO:0000313|EMBL:EFE33214.1};
OS Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS mentagrophytes).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=663331 {ECO:0000313|EMBL:EFE33214.1, ECO:0000313|Proteomes:UP000008866};
RN [1] {ECO:0000313|Proteomes:UP000008866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4681 / CBS 112371 {ECO:0000313|Proteomes:UP000008866};
RX PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT "Comparative and functional genomics provide insights into the
RT pathogenicity of dermatophytic fungi.";
RL Genome Biol. 12:R7.1-R7.16(2011).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFE33214.1}.
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DR EMBL; ABSU01000011; EFE33214.1; -; Genomic_DNA.
DR RefSeq; XP_003013854.1; XM_003013808.1.
DR STRING; 663331.D4AUP9; -.
DR GeneID; 9521272; -.
DR KEGG; abe:ARB_07966; -.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_31_0_1; -.
DR OMA; GMMCDDW; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000008866; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF20; HYBRID PKS-NRPS SYNTHETASE APDA; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008866};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2..452
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2423..2498
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2502..2588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2527..2541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2588 AA; 281629 MW; 7398EF172B6C3D5D CRC64;
MIEPIAIIGS GFRFPGGADT PSKLWSVIHN PRDLSSKPPT SRFDIDSFYH PVGTHHGTTN
ATKSYWLEDT DKSNVTKFDA GFFNIQPSEV DAMDPQQRVL MEVVYDGLCA AGQPMEKLRG
SDTAVYVGLM SDDWSTMLTR DWETLPRYTA TGLERGIVAN RVSYFFDWHG PSMTIDTACS
SSLVALDLGV QALRSGKSKV AVAAGTNLIL SPAMYISESN LGMLSPTGRC AMWDASADGY
ARGEGVAAVV LKTLSQAIAD NDPIECIIRE TAVNQDGKTT GLTMPSNVAQ TNLIRECYAR
AGLDPVNNLE DRPQFFHAHG TGTQAGDPQE AEAISNALFP AGSYADKMAD KLLVGSIKTV
IGHTEGTAGL ASVISTSLAL KYGVVPPNLH FANLSAKVAP FFKHLDIPTV PTPWPAKEDQ
PQMILFSPIT VLTLPFDSFG FGGTNAHCIL EQYIPEKKAV SPIFTPLTFS ASSEITLREM
LSQHLDYLVA NPETEFSDLA YTLQHRRSTL SYRKAIAAMT IQDAIKSLDE IVNSTSNATG
SAELGTRFGT ISDPKIIGIF TGQGAQWPRM GAQLLETSIF AASRISELDS ALQSLPSPGD
RPTWTLKDQL LAGKDTSRIA EAALSQPLCT AVQIILVDIL REAGISFRAV VGHSSGEIGA
AYAAGFISAQ DAIRVAYFRG VHARLASSPN EHAPRGAMMA VGASADDARD FCATTGFSGR
LQVAAVNSAS SVTLSGDEDA VTEAEEIFKS QGIFARKLKV DTAYHSAHMA SCAGPYFSSL
EGCAIQSVAP LQGSATTWFS SVYAGEPMTS DRLTNQYWVD NMCNAVLFAD ALSKALKHVD
QFDLAIEVGP HPALKGPATS TIGSIPYTGL LSRGLEDVTQ LSDALGFIWT RLGSGSVRFS
DVETLLSGVQ SRKSLKDLPS YPFEHQRSYW TNSRLANHFK NRRAIHLPNP VLGSPCSEAT
TPGEFQWRNF LRPNDMPWLK GHRLQGQTVF PATGYVSMAV EAIKGIVFDN GAGNSIGMIR
LTDVDIPRAI AFNDDDSSIE IIFSLSSIDI SPTTITAEWG CYSVADGSNI LLNAKGKVSV
QLSSAKPNTL PLVKAEPFNL VAVQDDRFYS NLSTVGYGYS HPFRGVSDIQ RKSGYSIGTL
FDQSGSEWDD NLVLHPGMLD SALQTVFAAW SYPGDTQLWS LHVPVSISSV TINPYFTILG
AGGKQGTMKF ETLIRSKQRS QIIGDIYLNT DNKSHAIVQF EGATLVPFSP ATPKNDLPMF
SHFEYRVASP DGLLAAEGET VTDFEVQMYK DIDRVSYWFA RHASISIPVE ERAGLLPHFQ
KYLQWCDRMV GMVSRGETPK VEPECNNDSR EDIGKILARY KGRKDIRFVE VVGDNLIPVI
RAGNSMLEHM NQDGLLRAFY EENAICAGPT SRWLARVVSQ ISHRYPGLNI FEIGAGTGAT
TSSVLRNLKG AYSSYTFTDI SSGFFMAAEE RFAKESGRMT FKVFDMEKGP AEQGFIEGSY
DLIVAVNVLH VSADMEASMS NIRRLLKPGG YIVVGELTST DLLFSGMTVG TLPGWWIGAE
TGRPWGPLLT LDQWDSVLKK TGFSGIDTVT PNIDSSLPIS VFVGQAINDQ VTLLRNPLNV
QEHPVGVRTD ALAIIGGTTD RVKELGHNVS GILSHRFPVK EFFDTVEDFA CSTMARSVSI
SGAVTILSLT DLDQPYLDGL TTDKFNALKA CTTAGTVVWV TCGSREDTPY SYMMMGFART
IKNENPDLNL QLFDLDSKAA NDGIEPQTAA ILAETLLRQR VLQSWGIDED ALLWTDEPEV
FMDNGKQLIT RLLPDPEKNM RYNSQRREIF TEANPMIDTL ELVGAGSGKG RVLELHKVSP
LRLPNIPETK YRALRITHSL LQTVAVGAAG FFRLCMGVDV NSNETILALS SSPESPVNVP
EHCCIAVPRT FDNNTLVSIA SSIVAERVLS FTPEGGILLV NEADPSLVSA IQRKASAKDV
KPVFITAKLR QNSNGDSLFL HPNFPRHIIK SIVPETTAVF LHFLRGDTSD AVRDCIIPCL
PASCLQINEE AVLGHELTEI SSAKSLIDIS QILQSALNDI DKAASEDANY ISLDSLPSHG
IIGEPMTVVQ WTTSTPLTAK VQPIDSGMLF KANRTYLFVG MAGELGQSLA GWMIAHGARN
IVLTSRTPKV NASFIEDMMK RYGAVVKAMP LNVTSRESLH YVHTAITATL PPIAGVVNGA
MILEDELFSR MTYEQYTRVI EPKVLGTQLL DERFYDDKSL DFFIVASSIA SVIGWSGQSN
YSAANEYMTS LVYKRRNRGV AASAMSIPAV LGVGYAANSI NFDFDYFQSV GYINISEEDL
HILFAEAVVS GRPSQAPQVK AQVAMGVNYL PNDFFVQEAH RRDVKFNHFI QREETGSEIQ
AVKSGVRVRV QLQAAKNAED SYIITRDAFL SHLKRMLRMT EEQKLEDSIA LVDQGVDSLV
AVDIRSWFLK ELEVDIPTLK ILGGGSIADL VKTALENMEP IKEDAPESSE PSPKQKHQPG
KPSGSIPKKE TASSSPLSMG SPVFTPALGD TPSPSDDDSI STPLPSREDF VKKGDLKSQG
KPIRTVIA
//
