ID D4AZD2_ARTBC Unreviewed; 561 AA.
AC D4AZD2;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 13-SEP-2023, entry version 51.
DE RecName: Full=Zinc transporter {ECO:0000256|RuleBase:RU369017};
GN ORFNames=ARB_01552 {ECO:0000313|EMBL:EFE31652.1};
OS Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS mentagrophytes).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=663331 {ECO:0000313|EMBL:EFE31652.1, ECO:0000313|Proteomes:UP000008866};
RN [1] {ECO:0000313|Proteomes:UP000008866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4681 / CBS 112371 {ECO:0000313|Proteomes:UP000008866};
RX PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT "Comparative and functional genomics provide insights into the
RT pathogenicity of dermatophytic fungi.";
RL Genome Biol. 12:R7.1-R7.16(2011).
CC -!- FUNCTION: Functions as a zinc transporter.
CC {ECO:0000256|RuleBase:RU369017}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU369017}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU369017}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily.
CC {ECO:0000256|RuleBase:RU369017}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU369017}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFE31652.1}.
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DR EMBL; ABSU01000020; EFE31652.1; -; Genomic_DNA.
DR RefSeq; XP_003012292.1; XM_003012246.1.
DR AlphaFoldDB; D4AZD2; -.
DR STRING; 663331.D4AZD2; -.
DR GeneID; 9519941; -.
DR KEGG; abe:ARB_01552; -.
DR eggNOG; KOG1484; Eukaryota.
DR HOGENOM; CLU_013389_0_0_1; -.
DR OMA; IFYFMNL; -.
DR OrthoDB; 1218545at2759; -.
DR Proteomes; UP000008866; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006882; P:intracellular zinc ion homeostasis; IEA:InterPro.
DR Gene3D; 1.20.1510.10; Cation efflux protein transmembrane domain; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR InterPro; IPR045316; Msc2-like.
DR NCBIfam; TIGR01297; CDF; 1.
DR PANTHER; PTHR45755; -; 1.
DR PANTHER; PTHR45755:SF4; ZINC TRANSPORTER 7; 1.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF161111; Cation efflux protein transmembrane domain-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU369017};
KW Ion transport {ECO:0000256|RuleBase:RU369017};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369017};
KW Reference proteome {ECO:0000313|Proteomes:UP000008866};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU369017};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU369017}; Transport {ECO:0000256|RuleBase:RU369017}.
FT TRANSMEM 168..189
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369017"
FT TRANSMEM 221..245
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369017"
FT TRANSMEM 272..288
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369017"
FT TRANSMEM 300..318
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369017"
FT TRANSMEM 339..358
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369017"
FT TRANSMEM 364..386
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369017"
FT TRANSMEM 398..419
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369017"
FT TRANSMEM 457..475
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369017"
FT TRANSMEM 482..502
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369017"
FT TRANSMEM 514..532
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369017"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 561 AA; 60409 MW; C4904B3381FA7D59 CRC64;
MNGARGGKSH RGRGHKRNHG NSVNHALPQT LPYTGGVISP QDAHAPVYSS NLAKEEVSTQ
YLDKQGPGLM NTLNGGASWD EYHGHGYTAS QDELSFGHAT SSNVHMQTTQ KQRVPHSASP
QGLGQQIISG LLTAMPFVMS YLLAGPIRLG TAKSETQSTK TSHSLRSAGI PLVVSCAYVS
VALLVHGIYE KIRQGRVNGN AGPTDGFQSN RSSLYDGMRT AIWMILPLYA SFMIGFDVVI
AVLLLNIFTD SRTGSSGNTL TRTIRTLKRR KVSVLFIVAI AVLDMAYISS SQPLEVFKGY
TAIAATILLP SPGSLLTLTD TAVDEKFASR KDNIDDTATV NLVIGTVLGA LILFVVLFSG
GFSAVSLSFL PIFVVGLFTA TSQLIYGIDA TGRPSLPTIA SGAIVVIIAT FVTSQTHIIP
LQATRFGLAC LASFADSKMV HNDNHSQAKM EKKPSRMTIW LLGACEQWPF IHAILKERDS
RRIFYFMNLN LTFMVVQLTY GVVTGSLGLL SDSIHMLFDC FALAVGLAAA VMSKWPPSSR
FPYGYGKIDT LAGFGNGVFL M
//
