ID D4B340_ARTBC Unreviewed; 954 AA.
AC D4B340;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=DUF221 domain protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=ARB_02874 {ECO:0000313|EMBL:EFE30195.1};
OS Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS mentagrophytes).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=663331 {ECO:0000313|EMBL:EFE30195.1, ECO:0000313|Proteomes:UP000008866};
RN [1] {ECO:0000313|Proteomes:UP000008866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4681 / CBS 112371 {ECO:0000313|Proteomes:UP000008866};
RX PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT "Comparative and functional genomics provide insights into the
RT pathogenicity of dermatophytic fungi.";
RL Genome Biol. 12:R7.1-R7.16(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFE30195.1}.
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DR EMBL; ABSU01000032; EFE30195.1; -; Genomic_DNA.
DR RefSeq; XP_003010835.1; XM_003010789.1.
DR AlphaFoldDB; D4B340; -.
DR GeneID; 9524950; -.
DR KEGG; abe:ARB_02874; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_009187_1_0_1; -.
DR OMA; GKGFFAW; -.
DR OrthoDB; 1330110at2759; -.
DR Proteomes; UP000008866; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF154; DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008866};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 33..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 434..458
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 479..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 526..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 552..571
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 596..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 677..695
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..183
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 207..374
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 385..665
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 278..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 819..954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..836
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 839..872
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 954 AA; 108791 MW; B501C122D27F531C CRC64;
MGGIAQRDGP PSGADEFLKL ISNPFTSKLN YNAFWVSLGT SVGITAGLAL LFSLVRPRNS
VVYAPKLKHA DKAHAPPPLG KGIFAWITPI IKLKEDELVD RMGMDATIFL RFTRMCRNMF
CVMSIVGCLI MIPVNVHYSN RSLGQDKSLF DFMTPELVWG EPLWSNIACA WAFNFIIMYF
LWHNYRAIHR LRIRYFQSPE YQKSLHARTV MVTHIPQNYR TDEGLLRLTD EVNPTASIPR
ASIGRNMREL PGLIKEHDAM VRKLEEVLAK YFKDPDNLPP TRPTCKPSKK DHSGHSASEP
VDAIDYYTDR VRQLEMEIRH VRESIDKRNA MPYGFASWDT IEDAHAVAFA ARNKHPHGTT
IRLAPRPNDI IWDNLALTKS NLKWKRFMNA IWSTILTVIW IVPNAMIAIF LTNLSNLGKV
WPAFQTSLNG NPKTWAAVQG IASPAILSLV YIVLPIIFRR LAIRAGKKTK TARERHVIHS
LYAFFVFNNL VVFSLFSTVW QLFAVIIDAS KNGEDAWKAL QARGTFQSFV VALIHVAPFW
VNWLLQRNLG AAVDLIQMIN MVWIFFARKF FSPTPRKYIE WTAPPPFDYA SYYNYFLFYV
TTALCFSTLQ PIVLPVTALY FGVDSWLKKY LLLYIFVTKT ESGGRYWRVI YNRVVFAVIL
SNFVTGLIVT AQGSWTMVYS LVPLPLLMLG FKWYCRVTFD NKMQYYNRAL VTDPEAMATS
KSSKKMVERL SSRFGHPALY KPLTTPMVHA KAAGALEKFY QSRQGLGAET GEYSDIAMHR
MSSTRPGKSE HTRDRPFEVV AENQLDFSYF KDRPDFRDEF GGGIYGRPDD VFTERSHTPK
SFLMGTGDSP SSSRASSPTP STYSQQARGS MSFPAHAHNR VPQLSDHPAF QPNEPEEPSF
YTAPNESERR LLSHAQTTPF RHDAEMSSID RWQSHTSEAR EPSPSGFTPY RGHR
//
