ID D4E152_SEROD Unreviewed; 311 AA.
AC D4E152;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE RecName: Full=p-hydroxybenzoic acid efflux pump subunit AaeA {ECO:0000256|HAMAP-Rule:MF_01544};
DE Short=pHBA efflux pump protein A {ECO:0000256|HAMAP-Rule:MF_01544};
GN Name=aaeA {ECO:0000256|HAMAP-Rule:MF_01544};
GN ORFNames=HMPREF0758_1826 {ECO:0000313|EMBL:EFE96397.1};
OS Serratia odorifera DSM 4582.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Serratia.
OX NCBI_TaxID=667129 {ECO:0000313|EMBL:EFE96397.1, ECO:0000313|Proteomes:UP000005723};
RN [1] {ECO:0000313|EMBL:EFE96397.1, ECO:0000313|Proteomes:UP000005723}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 4582 {ECO:0000313|EMBL:EFE96397.1,
RC ECO:0000313|Proteomes:UP000005723};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Forms an efflux pump with AaeB. {ECO:0000256|HAMAP-
CC Rule:MF_01544}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01544};
CC Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01544}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477, ECO:0000256|HAMAP-
CC Rule:MF_01544}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFE96397.1}.
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DR EMBL; ADBY01000032; EFE96397.1; -; Genomic_DNA.
DR RefSeq; WP_004958080.1; NZ_GG753567.1.
DR AlphaFoldDB; D4E152; -.
DR STRING; 667129.HMPREF0758_1826; -.
DR HOGENOM; CLU_018816_15_2_6; -.
DR OrthoDB; 9811754at2; -.
DR Proteomes; UP000005723; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR HAMAP; MF_01544; AaeA; 1.
DR InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR InterPro; IPR022871; PHBA_efflux_pump_AaeA.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30367:SF12; P-HYDROXYBENZOIC ACID EFFLUX PUMP SUBUNIT AAEA; 1.
DR PANTHER; PTHR30367; P-HYDROXYBENZOIC ACID EFFLUX PUMP SUBUNIT AAEA-RELATED; 1.
DR Pfam; PF13533; Biotin_lipoyl_2; 1.
DR Pfam; PF13437; HlyD_3; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01544};
KW Membrane {ECO:0000256|HAMAP-Rule:MF_01544};
KW Reference proteome {ECO:0000313|Proteomes:UP000005723};
KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_01544};
KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01544};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01544}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01544"
FT DOMAIN 47..94
FT /note="Membrane fusion protein biotin-lipoyl like"
FT /evidence="ECO:0000259|Pfam:PF13533"
SQ SEQUENCE 311 AA; 34074 MW; 4F3BCA2BCE8D2550 CRC64;
MKTFSIKIAR IAITLILVLL GIVAVFKAWV FYTESPWTRD AKFTADVVAI APDVSGLLTS
VPVVDNQLVK QGQVLFVIDQ PRYQQALAEA NADVAYYQTL AAEKKREAGR RVKLGIQAMS
QEEIDQANNV LQTVQHQLAK SIAVRDLAKL DLERTTVRAP ADGWITNLNV HAGEFITRGS
TAVALVKKNT FYVLAYLEET KLHGLSKGDR VEITPLGSNR IMHGTVDSVA AGVNNSSSTN
DSKGLAAIDS NLEWVRLAQR VPVKIILDAE DQQHPYPAGT TATVVVTGKG DRDRDGSSPF
VRLMHRLREF G
//
