ID D4GTB0_HALVD Unreviewed; 334 AA.
AC D4GTB0; L9V8F0;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=HTH domain protein / biotin--[acetyl-CoA-carboxylase] ligase {ECO:0000313|EMBL:ADE02722.1};
DE EC=6.3.4.15 {ECO:0000313|EMBL:ADE02722.1};
GN Name=birA {ECO:0000313|EMBL:ADE02722.1};
GN OrderedLocusNames=HVO_2485 {ECO:0000313|EMBL:ADE02722.1};
OS Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 /
OS NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloferax.
OX NCBI_TaxID=309800 {ECO:0000313|EMBL:ADE02722.1, ECO:0000313|Proteomes:UP000008243};
RN [1] {ECO:0000313|EMBL:ADE02722.1, ECO:0000313|Proteomes:UP000008243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 /
RC VKM B-1768 / DS2 {ECO:0000313|Proteomes:UP000008243};
RX PubMed=20333302; DOI=10.1371/journal.pone.0009605;
RA Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R.,
RA Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J.,
RA Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.;
RT "The complete genome sequence of Haloferax volcanii DS2, a model
RT archaeon.";
RL PLoS ONE 5:E9605-E9605(2010).
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DR EMBL; CP001956; ADE02722.1; -; Genomic_DNA.
DR RefSeq; WP_004042434.1; NZ_AOHU01000045.1.
DR AlphaFoldDB; D4GTB0; -.
DR STRING; 309800.HVO_2485; -.
DR PaxDb; 309800-C498_07718; -.
DR EnsemblBacteria; ADE02722; ADE02722; HVO_2485.
DR GeneID; 8924653; -.
DR KEGG; hvo:HVO_2485; -.
DR PATRIC; fig|309800.29.peg.1499; -.
DR eggNOG; arCOG01683; Archaea.
DR eggNOG; arCOG01940; Archaea.
DR HOGENOM; CLU_051096_0_0_2; -.
DR OrthoDB; 46252at2157; -.
DR Proteomes; UP000008243; Chromosome.
DR GO; GO:0004077; F:biotin-[acetyl-CoA-carboxylase] ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd16442; BPL; 1.
DR CDD; cd00090; HTH_ARSR; 1.
DR Gene3D; 2.30.30.100; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00978; Bifunct_BirA; 1.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR011991; ArsR-like_HTH.
DR InterPro; IPR030855; Bifunct_BirA.
DR InterPro; IPR004408; Biotin_CoA_COase_ligase.
DR InterPro; IPR003142; BPL_C.
DR InterPro; IPR004143; BPL_LPL_catalytic.
DR InterPro; IPR013196; HTH_11.
DR InterPro; IPR008988; Transcriptional_repressor_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00121; birA_ligase; 1.
DR PANTHER; PTHR12835; BIOTIN PROTEIN LIGASE; 1.
DR PANTHER; PTHR12835:SF5; BIOTIN--PROTEIN LIGASE; 1.
DR Pfam; PF02237; BPL_C; 1.
DR Pfam; PF03099; BPL_LplA_LipB; 1.
DR Pfam; PF08279; HTH_11; 1.
DR SUPFAM; SSF50037; C-terminal domain of transcriptional repressors; 1.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51733; BPL_LPL_CATALYTIC; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ADE02722.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008243}.
FT DOMAIN 62..269
FT /note="BPL/LPL catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51733"
FT REGION 176..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 334 AA; 35678 MW; 5F70F4DEA977EA54 CRC64;
MSDTRRTLLD ALAAGPVSGP DLADRLGVSR AAVWKHVEAL RDEGFGVESA GDGYVVTDVP
EYGAPAIEYG LDADYDVEFH ETLDSSNDRA RDLAAEGASD VVVVAREQTA SRGRKNREWS
APDGGVWLSL LVRPDEPPAY APLYTLAMAV AVCDAAREAG VDAKIKWPND VIVSEASGGS
PAHAGDRSTD ADAPDDRGYR KLCGILTEME GEADRVSWLV IGPGVNVNLD PAELPEVATS
VAAEAGPVER RVFVQRVLER FDALRSDLDA VLPAWRERAD TLGRRVRVHT ASGVIEGDAV
DIEHPGTLVV STDAGEKRVH AGDCEHLRPA DDGR
//
