ID D4JUK6_9FIRM Unreviewed; 423 AA.
AC D4JUK6;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 24-JAN-2024, entry version 64.
DE SubName: Full=Diaminopimelate decarboxylase {ECO:0000313|EMBL:CBK96775.1};
DE EC=4.1.1.20 {ECO:0000313|EMBL:CBK96775.1};
GN ORFNames=EUS_16800 {ECO:0000313|EMBL:CBK96775.1};
OS [Eubacterium] siraeum 70/3.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Oscillospiraceae incertae sedis.
OX NCBI_TaxID=657319 {ECO:0000313|EMBL:CBK96775.1, ECO:0000313|Proteomes:UP000008803};
RN [1] {ECO:0000313|EMBL:CBK96775.1, ECO:0000313|Proteomes:UP000008803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=70/3 {ECO:0000313|EMBL:CBK96775.1,
RC ECO:0000313|Proteomes:UP000008803};
RG metaHIT consortium -- http://www.metahit.eu/;
RA Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT "The genome sequence of Eubacterium siraeum 70/3.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBK96775.1, ECO:0000313|Proteomes:UP000008803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=70/3 {ECO:0000313|EMBL:CBK96775.1,
RC ECO:0000313|Proteomes:UP000008803};
RA Pajon A.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR600183-50};
CC -!- SIMILARITY: Belongs to the Orn/Lys/Arg decarboxylase class-II family.
CC {ECO:0000256|RuleBase:RU003737}.
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DR EMBL; FP929044; CBK96775.1; -; Genomic_DNA.
DR AlphaFoldDB; D4JUK6; -.
DR KEGG; esu:EUS_16800; -.
DR PATRIC; fig|657319.3.peg.1994; -.
DR HOGENOM; CLU_026444_0_2_9; -.
DR BioCyc; ESIR657319:G136K-1420-MONOMER; -.
DR Proteomes; UP000008803; Chromosome.
DR GO; GO:0008836; F:diaminopimelate decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:InterPro.
DR CDD; cd06828; PLPDE_III_DapDC; 1.
DR Gene3D; 3.20.20.10; Alanine racemase; 1.
DR InterPro; IPR009006; Ala_racemase/Decarboxylase_C.
DR InterPro; IPR002986; DAP_deCOOHase_LysA.
DR InterPro; IPR022643; De-COase2_C.
DR InterPro; IPR022644; De-COase2_N.
DR InterPro; IPR000183; Orn/DAP/Arg_de-COase.
DR InterPro; IPR029066; PLP-binding_barrel.
DR PANTHER; PTHR43727; DIAMINOPIMELATE DECARBOXYLASE; 1.
DR PANTHER; PTHR43727:SF2; DIAMINOPIMELATE DECARBOXYLASE 1, CHLOROPLASTIC-RELATED; 1.
DR Pfam; PF02784; Orn_Arg_deC_N; 1.
DR Pfam; PF00278; Orn_DAP_Arg_deC; 1.
DR PRINTS; PR01181; DAPDCRBXLASE.
DR PRINTS; PR01179; ODADCRBXLASE.
DR SUPFAM; SSF50621; Alanine racemase C-terminal domain-like; 1.
DR SUPFAM; SSF51419; PLP-binding barrel; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:CBK96775.1};
KW Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR600183-50}.
FT DOMAIN 47..280
FT /note="Orn/DAP/Arg decarboxylase 2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02784"
FT DOMAIN 282..370
FT /note="Orn/DAP/Arg decarboxylase 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00278"
FT ACT_SITE 343
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
FT MOD_RES 55
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
SQ SEQUENCE 423 AA; 47551 MW; 4D1430CB4CE82EEA CRC64;
MSKVPFTTKE KLEEIIKQIP TPFHIYDEKG IRETARKLYD AFSWNKGFRE YFAVKATPNP
YIMEILKEEG CGFDCSSYTE LMLSDKVGAK QHDIMFSSNA TPDEDFKLAY KLGAIINLDD
FTHIDVLDKL TGIPETICCR YNPGGEFKTS EKGNVMDTPK DAKYGMTHEQ IIEAYKILKE
KGAKRFGMHA FLASNTLTNE YYPVLAGILF RTAVEIKEKT GVQLSFINLS GGVGVPYKPD
QPANDIKVIG EGVRKAYEEI LVPAGMGDVA IFTELGRYML APNGALVAKA IREKHIYKEY
IGLDACAANL MRPAIYGAYH HITVMGKENQ PCDHKYDITG GLCENCDKFA VDRMLPKIDI
GDIIYIHDTG AHGFSMGYNY NGKLRSAEVL LKEDGSFKLI RRAETPKDYF ATFDFSDKYS
FSK
//
