ID   D4K0M6_9FIRM            Unreviewed;       795 AA.
AC   D4K0M6;
DT   18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT   18-MAY-2010, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   SubName: Full=Beta-galactosidase/beta-glucuronidase {ECO:0000313|EMBL:CBK99825.1};
DE            EC=3.2.1.23 {ECO:0000313|EMBL:CBK99825.1};
GN   ORFNames=FP2_25090 {ECO:0000313|EMBL:CBK99825.1};
OS   Faecalibacterium prausnitzii L2-6.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Faecalibacterium.
OX   NCBI_TaxID=718252 {ECO:0000313|EMBL:CBK99825.1, ECO:0000313|Proteomes:UP000008804};
RN   [1] {ECO:0000313|EMBL:CBK99825.1, ECO:0000313|Proteomes:UP000008804}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L2-6 {ECO:0000313|Proteomes:UP000008804};
RG   metaHIT consortium -- http://www.metahit.eu/;
RA   Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT   "The genome sequence of Faecalibacterium prausnitzii L2/6.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBK99825.1, ECO:0000313|Proteomes:UP000008804}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L2-6 {ECO:0000313|Proteomes:UP000008804};
RA   Pajon A.;
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC       {ECO:0000256|ARBA:ARBA00007401}.
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DR   EMBL; FP929045; CBK99825.1; -; Genomic_DNA.
DR   AlphaFoldDB; D4K0M6; -.
DR   STRING; 718252.FP2_25090; -.
DR   CAZy; GH2; Glycoside Hydrolase Family 2.
DR   KEGG; fpr:FP2_25090; -.
DR   PATRIC; fig|718252.3.peg.697; -.
DR   eggNOG; COG3250; Bacteria.
DR   HOGENOM; CLU_006501_5_1_9; -.
DR   BioCyc; FPRA718252:G1375-2138-MONOMER; -.
DR   Proteomes; UP000008804; Chromosome.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030245; P:cellulose catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR006103; Glyco_hydro_2_cat.
DR   InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR   InterPro; IPR006104; Glyco_hydro_2_N.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR42732; BETA-GALACTOSIDASE; 1.
DR   PANTHER; PTHR42732:SF1; BETA-MANNOSIDASE; 1.
DR   Pfam; PF00703; Glyco_hydro_2; 1.
DR   Pfam; PF02836; Glyco_hydro_2_C; 1.
DR   Pfam; PF02837; Glyco_hydro_2_N; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023001};
KW   Cellulose degradation {ECO:0000256|ARBA:ARBA00023001};
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000313|EMBL:CBK99825.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:CBK99825.1};
KW   Polysaccharide degradation {ECO:0000256|ARBA:ARBA00023001};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008804}.
FT   DOMAIN          45..152
FT                   /note="Glycosyl hydrolases family 2 sugar binding"
FT                   /evidence="ECO:0000259|Pfam:PF02837"
FT   DOMAIN          159..257
FT                   /note="Glycoside hydrolase family 2 immunoglobulin-like
FT                   beta-sandwich"
FT                   /evidence="ECO:0000259|Pfam:PF00703"
FT   DOMAIN          265..470
FT                   /note="Glycoside hydrolase family 2 catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF02836"
SQ   SEQUENCE   795 AA;  88577 MW;  D4FDAA76D245A930 CRC64;
     MEHYDWNDGW LFTPVFDPAI VRPECPELTL EPVRLPHTVK ALPYNYCNEN DYQKLSGYRR
     EFFAPKEWEG RTVLLTFGAV AHDATVFCNG RRVFHHSCGY TAFTVDLTSA LHLGQKNVMA
     VRCDSREDLN IPPFGGQMDF LTYGGICRAV CLDVKEPAYL RDIFIETKAE GGFRIYTATV
     GETVGCTLQA EIRSPSGSRA FYTGELSLPI TGALNSVHPW SIEHPTLYTL TVRLIRPGTG
     GLPDRVLDEK SCRFGFRTLQ FVAGGLYLNG QRVELRGLNR RQSYAYQGYA MPDSIQRLDA
     QLLKKQLGCN AVRLTTPPSP AFLDACDELG LLVFVEMPGW QHIGDDIWKA QALQNCREMV
     CQCRSHPSIF LWGVRVSGSA DDESFYKRTN ETVRRLDPTR PTAGTRSTRR SQLLEDVYAY
     TDYSYHGRGV GCEARTAVTP DTRKGYLISE FEGAQFPAKS FDDEPHRLAQ ALRYAAVLND
     TIAQQGVAGS FGWCMTDYNT HREFGSGDRI SYQGVMDMFR GPKLSAAVYA SQKTPRSPSD
     IVLEISSSMA LGDHPGGFAG ACWAFTNAES LRLYRDNDFV AEFTPDRRGR FAALPHPPIE
     IHDFVGLLLE KYEGLDRTAA PQVAAILNEM RRDAMELSPL SRARMYSLRL SWNELVQLYY
     KYIGVLGSPA AVYRFEAVWH GRAVRTVVKE PVQSVRLECT VHNPILTDGP TWDCAAVSLR
     AIDQNGNLLP YCGEAVQLSA EGPLRILGPS VVPLRGGMAG TYLATTGEAG PAKLHCRMEG
     ALDTEASLTI RCREE
//