ID D4K3M1_9FIRM Unreviewed; 639 AA.
AC D4K3M1;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Small GTP-binding protein domain {ECO:0000313|EMBL:CBK98114.1};
GN ORFNames=FP2_04740 {ECO:0000313|EMBL:CBK98114.1};
OS Faecalibacterium prausnitzii L2-6.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Faecalibacterium.
OX NCBI_TaxID=718252 {ECO:0000313|EMBL:CBK98114.1, ECO:0000313|Proteomes:UP000008804};
RN [1] {ECO:0000313|EMBL:CBK98114.1, ECO:0000313|Proteomes:UP000008804}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=L2-6 {ECO:0000313|Proteomes:UP000008804};
RG metaHIT consortium -- http://www.metahit.eu/;
RA Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT "The genome sequence of Faecalibacterium prausnitzii L2/6.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBK98114.1, ECO:0000313|Proteomes:UP000008804}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=L2-6 {ECO:0000313|Proteomes:UP000008804};
RA Pajon A.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC synthesis by a non-covalent modification of the ribosomes.
CC {ECO:0000256|ARBA:ARBA00003987}.
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DR EMBL; FP929045; CBK98114.1; -; Genomic_DNA.
DR RefSeq; WP_002586627.1; NC_021042.1.
DR AlphaFoldDB; D4K3M1; -.
DR SMR; D4K3M1; -.
DR STRING; 718252.FP2_04740; -.
DR GeneID; 85154867; -.
DR KEGG; fpr:FP2_04740; -.
DR PATRIC; fig|718252.3.peg.1682; -.
DR eggNOG; COG0480; Bacteria.
DR HOGENOM; CLU_002794_4_2_9; -.
DR BioCyc; FPRA718252:G1375-390-MONOMER; -.
DR Proteomes; UP000008804; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR CDD; cd03711; Tet_C; 1.
DR CDD; cd03690; Tet_II; 1.
DR CDD; cd16258; Tet_III; 1.
DR CDD; cd01684; Tet_like_IV; 1.
DR CDD; cd04168; TetM_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR035650; Tet_C.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43261:SF1; RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43261; TRANSLATION ELONGATION FACTOR G-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR PRINTS; PR01037; TCRTETOQM.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000008804}.
FT DOMAIN 1..243
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 639 AA; 71295 MW; 9043F095B9CF38B5 CRC64;
MKIINIGILA HVDAGKTTLT ESLLYASGAI SEPGSVEKGT TRTDTMFLER QRGITIQAAV
TSFQWHRCKV NIVDTPGHMD FLAEVYRSLA VLDGAILVIS AKDGVQAQTR ILFHALRKMN
IPTVIFINKI DQAGVDLQSV VQSVRDKLSA DIIIKQTVSL SPEIVLEENT DIEAWDAVIE
NNDELLEKYI AGEPISREKL AREEQQRVQD ASLFPVYHGS AKNGLGIQPL MDAVTGLFQP
IGEQGGAALC GSVFKVEYTD CGQRRVYLRL YSGTLRLRDT VALAGREKLK ITEMRIPSKG
EIVRTDTAYQ GEIVILPSDS VRLNDVLGDQ TRLPRKRWRE DPLPMLRTTI APKTAAQRER
LLDALTQLAD TDPLLRCEVD SITHEIILSF LGRVQLEVVS ALLSEKYKLE TVVKEPSVIY
MERPLKAASH TIHIEVPPNP FWASIGLSVT PLSLGSGVQY ESRVSLGYLN QSFQNAVRDG
IRYGLEQGLF GWNVTDCKIC FEYGLYYSPV STPADFRSLA PIVLEQALKE SGTQLLEPYL
SFILYAPQEY LSRAYHDAPK YCATIETAQV KKDEVVFTGE IPARCIQAYR TDLAFYTNGR
SVCLTELKGY QAAVGQPVIQ PRRPNSRLDK VRHMFQKVM
//
