ID D4L433_9FIRM Unreviewed; 411 AA.
AC D4L433;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE RecName: Full=DNA (cytosine-5-)-methyltransferase {ECO:0000256|ARBA:ARBA00011975};
DE EC=2.1.1.37 {ECO:0000256|ARBA:ARBA00011975};
GN ORFNames=RO1_42050 {ECO:0000313|EMBL:CBL14373.1};
OS Roseburia intestinalis XB6B4.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX NCBI_TaxID=718255 {ECO:0000313|EMBL:CBL14373.1, ECO:0000313|Proteomes:UP000008953};
RN [1] {ECO:0000313|EMBL:CBL14373.1, ECO:0000313|Proteomes:UP000008953}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XB6B4 {ECO:0000313|EMBL:CBL14373.1,
RC ECO:0000313|Proteomes:UP000008953};
RG metaHIT consortium -- http://www.metahit.eu/;
RA Pajon A., Turner K., Parkhill J., Bernalier A.;
RT "The genome sequence of Roseburia intestinalis XB6B4.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBL14373.1, ECO:0000313|Proteomes:UP000008953}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XB6B4 {ECO:0000313|EMBL:CBL14373.1,
RC ECO:0000313|Proteomes:UP000008953};
RA Pajon A.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016, ECO:0000256|RuleBase:RU000416}.
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DR EMBL; FP929050; CBL14373.1; -; Genomic_DNA.
DR RefSeq; WP_006858886.1; NC_021012.1.
DR AlphaFoldDB; D4L433; -.
DR REBASE; 32063; M.Rin6ORF42050P.
DR GeneID; 61431647; -.
DR KEGG; rix:RO1_42050; -.
DR PATRIC; fig|718255.3.peg.1531; -.
DR HOGENOM; CLU_006958_2_0_9; -.
DR Proteomes; UP000008953; Chromosome.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00675; dcm; 1.
DR PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10629:SF52; DNA (CYTOSINE-5)-METHYLTRANSFERASE 1; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR PRINTS; PR00105; C5METTRFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}.
FT ACT_SITE 92
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 411 AA; 46490 MW; 6A44FBF075C08E90 CRC64;
MSQFSYIDIF AGCGGLSLGL HNAGWKGLFA IEKSKDAFET LKYNLIDTTQ HFGWNEWLPQ
TEHDINEVIS KYRSELEKLA GTVTLVVGGP PCQGFSMAGQ RKKNDIRNTL SDSYIEFISI
VKPKFLVFEN VQGFTIGFKD ENEKKGVPYS VILKEKLEKL GYSVEGKMID ISEFGVPQTR
KRYIMVGVLQ GKTEMFFDIL YKRKKDFLKK KGLNEKVSVG EAIGDLLKEN GTLPTPDFKN
YVSGVYGEIQ SNYQKLMRKG LDNMEGCVAD SHRFAKHSEE TKRMNEEMLQ KCPKLKRVTP
KDNLIKNLRK RGVTVLDESK AAPTVTAHPD DFVHYCEPRI LTVRESARIQ SFPDSFQFKG
KYTTGGQLRK IEVPRCTQVG NAVPPLFAEQ IGNALMEMMK NGITESEKST I
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