ID D4LCH0_RUMC1 Unreviewed; 454 AA.
AC D4LCH0;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369};
GN OrderedLocusNames=RUM_11710 {ECO:0000313|EMBL:CBL17315.1};
OS Ruminococcus champanellensis (strain DSM 18848 / JCM 17042 / KCTC 15320 /
OS 18P13).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Ruminococcus.
OX NCBI_TaxID=213810 {ECO:0000313|EMBL:CBL17315.1, ECO:0000313|Proteomes:UP000007054};
RN [1] {ECO:0000313|EMBL:CBL17315.1, ECO:0000313|Proteomes:UP000007054}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18848 / JCM 17042 / 18P13
RC {ECO:0000313|Proteomes:UP000007054};
RA Pajon A., Turner K., Parkhill J., Bernalier A.;
RT "The genome sequence of Ruminococcus sp. 18P13.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000308};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC {ECO:0000256|ARBA:ARBA00005163}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369}.
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DR EMBL; FP929052; CBL17315.1; -; Genomic_DNA.
DR RefSeq; WP_015558222.1; NC_021039.1.
DR AlphaFoldDB; D4LCH0; -.
DR STRING; 213810.RUM_11710; -.
DR GeneID; 83155913; -.
DR KEGG; rch:RUM_11710; -.
DR PATRIC; fig|213810.4.peg.1066; -.
DR HOGENOM; CLU_025068_2_2_9; -.
DR BioCyc; RCHA213810:RUM_RS05620-MONOMER; -.
DR UniPathway; UPA00223; -.
DR Proteomes; UP000007054; Chromosome.
DR GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR CDD; cd06113; citrate_synt_like_1_2; 1.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR11739:SF4; CITRATE SYNTHASE, PEROXISOMAL; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:CBL17315.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007054};
KW Transferase {ECO:0000256|PIRNR:PIRNR001369, ECO:0000313|EMBL:CBL17315.1}.
FT ACT_SITE 332
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT ACT_SITE 391
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ SEQUENCE 454 AA; 51129 MW; 5EC75270F740345B CRC64;
MGKYQSIDLD TKISQLVNLC EKNYNIDPAL YQKYDVKRGL RDINGQGVRA GLTNISNVSA
TAIVDGESVP ARGKLYYRGI DVEQIVKGFS EENRFGFEET VYLLLFGELP TKDALRQFQQ
LLVEARPLPT TFTRDVIMKS PSDDMMNTLA RSVLTLYSYD PNPNDLSIAN VLKQCIRLIA
QFPSLAVYGY QAFEYYKNDE SLFLHHPNPE LSTAENILYM LRPDSKYSDL EAKILDLALV
LHAEHGGGNN SSFTVHVVSS SGTDTYSAIA AALGSLKGPK HGGANIKVVH MFDDMMQTLP
DWTDEEAVKN YLRALLHKEA FDRAGLIYGM GHAVYSISDP RATVFKGFVE KLSEEKGYQK
EFALYSLVER LAPSVIAEER RIYKGVCANV DFYSGFVYRM LGLPYELFTP IFAISRIAGW
SAHRLEELIN ANKIIRPAYK AVKDEIPYQK LEDR
//
