ID D4LF06_RUMC1 Unreviewed; 447 AA.
AC D4LF06;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Hemolysins and related proteins containing CBS domains {ECO:0000313|EMBL:CBL18201.1};
GN OrderedLocusNames=RUM_21860 {ECO:0000313|EMBL:CBL18201.1};
OS Ruminococcus champanellensis (strain DSM 18848 / JCM 17042 / KCTC 15320 /
OS 18P13).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Ruminococcus.
OX NCBI_TaxID=213810 {ECO:0000313|EMBL:CBL18201.1, ECO:0000313|Proteomes:UP000007054};
RN [1] {ECO:0000313|Proteomes:UP000007054}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18848 / JCM 17042 / 18P13
RC {ECO:0000313|Proteomes:UP000007054};
RA Pajon A., Turner K., Parkhill J., Bernalier A.;
RT "The genome sequence of Ruminococcus sp. 18P13.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the UPF0053 family.
CC {ECO:0000256|ARBA:ARBA00006337}.
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DR EMBL; FP929052; CBL18201.1; -; Genomic_DNA.
DR RefSeq; WP_015559107.1; NZ_BBEP01000025.1.
DR AlphaFoldDB; D4LF06; -.
DR STRING; 213810.RUM_21860; -.
DR GeneID; 83156841; -.
DR KEGG; rch:RUM_21860; -.
DR PATRIC; fig|213810.4.peg.2073; -.
DR HOGENOM; CLU_015237_4_1_9; -.
DR OrthoDB; 9798188at2; -.
DR BioCyc; RCHA213810:RUM_RS10615-MONOMER; -.
DR Proteomes; UP000007054; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR InterPro; IPR005170; Transptr-assoc_dom.
DR PANTHER; PTHR22777; HEMOLYSIN-RELATED; 1.
DR PANTHER; PTHR22777:SF33; UPF0053 PROTEIN YEGH; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF01595; CNNM; 1.
DR Pfam; PF03471; CorC_HlyC; 1.
DR SMART; SM01091; CorC_HlyC; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR PROSITE; PS51371; CBS; 1.
DR PROSITE; PS51846; CNNM; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000007054};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 64..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..208
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 293..350
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 447 AA; 49506 MW; B197FCBBBBBA465F CRC64;
MEPDGSRIWI YVLLILVFAL LKGVYTACEY AVTEVNDSKV KTLAETDSRY ARLLKLIEAP
QKMMLAFSMQ RALSCVMISI LAVMLLDAVL DTRLELQLLH GGAAGWIRAG MLAGLLLVTT
VLISSLTEQL PKRLVHRHID GFAVGCVGAV RLLTWVLAPV ALLAHGLTFV ACKLCGLPTD
DVRDSVTEEE IRMMVEAGNE TGAIEESERE MINNIFDFGD TVVSEVMTHR TDIIGAELHA
KIGDIVYLAI NEGVSRIPVY EQTIDNIVGI VYVKDLLCLV GCEHCEDFTL EQFRRDALYM
PETCKCREAF EQMTRAKQQM AVISDEYGGT AGIVTMEDLL EEIVGSIQDE YDDEASELEQ
LPDGGYSVDG AADPEDILPK LGVAVPEDNQ YDTMSALMVD LLGRIPEQQE RPAVEYQGLK
LTVLQTEDNW ISRIRVEQLK LAGEPTK
//
