ID D4M6R6_9FIRM Unreviewed; 450 AA.
AC D4M6R6;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Probable multidrug resistance protein NorM {ECO:0000256|ARBA:ARBA00020268};
DE AltName: Full=Multidrug-efflux transporter {ECO:0000256|ARBA:ARBA00031636};
GN ORFNames=RTO_24450 {ECO:0000313|EMBL:CBL26928.1};
OS [Ruminococcus] torques L2-14.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Mediterraneibacter.
OX NCBI_TaxID=657313 {ECO:0000313|EMBL:CBL26928.1, ECO:0000313|Proteomes:UP000008956};
RN [1] {ECO:0000313|EMBL:CBL26928.1, ECO:0000313|Proteomes:UP000008956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=L2-14 {ECO:0000313|EMBL:CBL26928.1,
RC ECO:0000313|Proteomes:UP000008956};
RG metaHIT consortium -- http://www.metahit.eu/;
RA Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT "The genome sequence of Ruminococcus torques L2-14.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBL26928.1, ECO:0000313|Proteomes:UP000008956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=L2-14 {ECO:0000313|EMBL:CBL26928.1,
RC ECO:0000313|Proteomes:UP000008956};
RA Pajon A.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Multidrug efflux pump. {ECO:0000256|ARBA:ARBA00003408}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FP929055; CBL26928.1; -; Genomic_DNA.
DR RefSeq; WP_015529506.1; NC_021015.1.
DR AlphaFoldDB; D4M6R6; -.
DR STRING; 33039.ERS852502_01251; -.
DR KEGG; rto:RTO_24450; -.
DR PATRIC; fig|657313.3.peg.2335; -.
DR HOGENOM; CLU_012893_5_3_9; -.
DR Proteomes; UP000008956; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR CDD; cd13137; MATE_NorM_like; 1.
DR InterPro; IPR002528; MATE_fam.
DR InterPro; IPR048279; MdtK-like.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR43298:SF2; FMN_FAD EXPORTER YEEO-RELATED; 1.
DR PANTHER; PTHR43298; MULTIDRUG RESISTANCE PROTEIN NORM-RELATED; 1.
DR Pfam; PF01554; MatE; 2.
DR PIRSF; PIRSF006603; DinF; 1.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 57..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 93..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 450 AA; 49274 MW; 7E1D6FC08C44774F CRC64;
MNANINQQHM FSNKMIRALL VPIILEQLLN SIMGTADTMM VSNVGSAAIS AVSLVDSINI
LVIQAFSALA AGGAIVCAQY IGQGNKERAN ESARQVLFII TLISVAVSAF CLIFQKPLLH
LIFGAVEADV MRASEIYFFY TALSFPFIAA YDAAASIFRA QENTRDPMLI SMVSNVMNIV
GNAIMIWGFH MGVAGAALAT LISRIFCAVV VLAELRLDRQ PIVVRDYLKI RPDWRMIRRI
LGIGIPSGVE NSMFQLGKLA IQSTVSTLGT TAIAAQAMTN ILENLNGIGG IGVGIGLMTI
VGQCLGADRK DEAVYYIKKL CVIAEIVMAA SCVIVFALTK PITILGGMEP ESAKMCFHMV
MWITIVKPLA WIMSFIPAYG MRAAGDAKFS MITSCCTMWA CRFCLCVFLI RVMGFGPMGV
WIGMFADWTV RSIIFTWRFH SRKWLEHKVI
//
