UniProt: D4MAG1

Database: UniProt
Entry: D4MAG1_9BACT

LinkDB:  D4MAG1_9BACT 
Original site:  D4MAG1_9BACT

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Ontology (3)   
   GO (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1)   
   KEGG GENES (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (13)   
   InterPro (8)   
   Pfam (4)   
   SMART (1)   
All databases (19)   

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ID   D4MAG1_9BACT            Unreviewed;      1154 AA.
AC   D4MAG1;
DT   18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT   18-MAY-2010, sequence version 1.
DT   13-SEP-2023, entry version 53.
DE   RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   ORFNames=SY1_21010 {ECO:0000313|EMBL:CBL28856.1};
OS   Fretibacterium fastidiosum.
OC   Bacteria; Synergistota; Synergistia; Synergistales; Aminobacteriaceae;
OC   Fretibacterium.
OX   NCBI_TaxID=651822 {ECO:0000313|EMBL:CBL28856.1, ECO:0000313|Proteomes:UP000008957};
RN   [1] {ECO:0000313|EMBL:CBL28856.1, ECO:0000313|Proteomes:UP000008957}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SGP1 {ECO:0000313|EMBL:CBL28856.1,
RC   ECO:0000313|Proteomes:UP000008957};
RG   metaHIT consortium -- http://www.metahit.eu/;
RA   Pajon A., Turner K., Parkhill J., Wade W., Vartoukian S.;
RT   "The genome sequence of Synergistetes sp. SGP1.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBL28856.1, ECO:0000313|Proteomes:UP000008957}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SGP1 {ECO:0000313|EMBL:CBL28856.1,
RC   ECO:0000313|Proteomes:UP000008957};
RA   Pajon A.;
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR   EMBL; FP929056; CBL28856.1; -; Genomic_DNA.
DR   AlphaFoldDB; D4MAG1; -.
DR   KEGG; sbr:SY1_21010; -.
DR   PATRIC; fig|651822.3.peg.1360; -.
DR   HOGENOM; CLU_001600_0_0_0; -.
DR   BioCyc; FFAS651822:G13GF-1269-MONOMER; -.
DR   Proteomes; UP000008957; Chromosome.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd04485; DnaE_OBF; 1.
DR   CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR   Gene3D; 1.10.150.870; -; 1.
DR   Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR004805; DnaE2/DnaE/PolC.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   NCBIfam; TIGR00594; polc; 1.
DR   PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; PHP domain-like; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW   ECO:0000313|EMBL:CBL28856.1};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000313|EMBL:CBL28856.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008957};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CBL28856.1}.
FT   DOMAIN          6..73
FT                   /note="Polymerase/histidinol phosphatase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00481"
SQ   SEQUENCE   1154 AA;  128140 MW;  87456A7F88CE6833 CRC64;
     MTRPFVHLHV HTEYSLLDGA IRTKQLAAKV ADWSVPAVAM TDHGVMYGAV EFYENCRAAG
     VKPILGCEIY VDPDGHRSRE KKGKNNHLIL LAENEEGYRN LVKLVSIANT DGFYYKPRID
     HDLLASCARG IIASSACLAG EVPQLVLQGR EDEAAKRALL YQDIMGKGNY FLEIMSNTLP
     EQAVVNKALI RIAKDTGIPL IATSDAHYLN AEDYEWHKIL LRINTHADDT DDAFGFSVND
     FYLRSPEEMD AIFGAEVPEA LDNTVAIAER CGVEMKLKTG HYMLPSLELQ EGMTLDSHLE
     DEARAGLRMR LNADTPPAEY AERLEYELNV ITRMGFSAYF LIVAGIIQAA KERGIPIGPG
     RGSAAGSLVA WSLRITELDP LKYNLLFERF LNPERISMPD IDTDVSDRGR EQLLKHIVER
     YGSDRVSQII TFGRMKSRQA VKDVGRAVGM EYALMDRVAK LIPADARSIR EALERTPELT
     ELAEEDPRIK NVLRTAEHIE GLARHASQHA AGVVITPVPI TDLVPIRRIK STAPSAPDGE
     LDVTQTVTQF TMEPVEKLGL VKMDFLGLQT LSILEEAVEN IRLNGKNPPD LLSLPMDDPA
     TYKLLQEADT MGVFQLESDG IRGMLRKLRI DCFDDLVAAL AMYRPGPLDS GMVDQYIKCK
     HGQAKLEYPH PLLEDVLKDT YGVILYQEQV MQSASVLAGY TLGEADLLRR AMGKKKVEVM
     QEQRAKFLDG ARQKGIDEKT ASGIFDLIEK FAGYGFNKSH SAAYALVSYQ TAYLKANYKA
     EFMASYLSSQ MKSKKDVLGH YVREVRQSGI SVLPPDVNSS MESFTAVGDV IRFGLGAVLR
     VGHNAVEAIV KAREEGPFKS LWDFLRRVDL HDMNRAMIEN LIKAGAFDEI TPNRARLVAA
     LPDFILAAQK MAAGGDQLSL FDAIGDDSGS DPEPDLPDVE EYGIYDKLDY EKEVTGLYIS
     GHPFDSCEAQ VRKYANCSIA DLPLWRGKTA PKVGGLILSV SEKTTKKGDL MGVLLLEDSE
     SSVSMVAFPR TWAKVKESAR VGVPCVAEGK MDDREQLLLD KLTPLSDFSE QDPQIVRIRL
     RVNLVPQFDV KNFARALRGC RGASPILLEL RDDHDACVLY LNDFRVDARS PERLHERLLE
     AVPAEALEVC LSAD
//

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