ID D4MTE1_9FIRM Unreviewed; 534 AA.
AC D4MTE1;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Stage 0 sporulation protein A homolog {ECO:0000256|ARBA:ARBA00018672};
GN ORFNames=CL3_33230 {ECO:0000313|EMBL:CBL37027.1};
OS butyrate-producing bacterium SM4/1.
OC Bacteria; Bacillota; Clostridia; Eubacteriales.
OX NCBI_TaxID=245012 {ECO:0000313|EMBL:CBL37027.1, ECO:0000313|Proteomes:UP000008959};
RN [1] {ECO:0000313|EMBL:CBL37027.1, ECO:0000313|Proteomes:UP000008959}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SM4/1 {ECO:0000313|EMBL:CBL37027.1,
RC ECO:0000313|Proteomes:UP000008959};
RG metaHIT consortium -- http://www.metahit.eu/;
RA Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT "The genome sequence of Clostridiales sp. SM4/1.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBL37027.1, ECO:0000313|Proteomes:UP000008959}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SM4/1 {ECO:0000313|EMBL:CBL37027.1,
RC ECO:0000313|Proteomes:UP000008959};
RA Pajon A.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play the central regulatory role in sporulation. It may
CC be an element of the effector pathway responsible for the activation of
CC sporulation genes in response to nutritional stress. Spo0A may act in
CC concert with spo0H (a sigma factor) to control the expression of some
CC genes that are critical to the sporulation process.
CC {ECO:0000256|ARBA:ARBA00024867}.
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DR EMBL; FP929060; CBL37027.1; -; Genomic_DNA.
DR AlphaFoldDB; D4MTE1; -.
DR KEGG; bprm:CL3_33230; -.
DR PATRIC; fig|245012.3.peg.2649; -.
DR HOGENOM; CLU_000445_5_0_9; -.
DR BioCyc; BBAC245012:G1313-1594-MONOMER; -.
DR Proteomes; UP000008959; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR CDD; cd17536; REC_YesN-like; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR018060; HTH_AraC.
DR InterPro; IPR018062; HTH_AraC-typ_CS.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR42713; HISTIDINE KINASE-RELATED; 1.
DR PANTHER; PTHR42713:SF3; TRANSCRIPTIONAL REGULATORY PROTEIN HPTR; 1.
DR Pfam; PF12833; HTH_18; 1.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00342; HTH_ARAC; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00169};
KW Reference proteome {ECO:0000313|Proteomes:UP000008959}.
FT DOMAIN 3..120
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT DOMAIN 427..526
FT /note="HTH araC/xylS-type"
FT /evidence="ECO:0000259|PROSITE:PS01124"
FT MOD_RES 55
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 534 AA; 60975 MW; 385DDAC764DF477D CRC64;
MYTVVVADDE EELRRAIIRR INWEEIGFQV VGEAENGIEA LELVGEKEPD LLLTDIRMPF
ISGVELARQV REIRPATQIA FLSGFDDFSY AQQAIQYNII SYMLKPISMA DLTENLIQIK
QKIDRLFSEF AVRRKNEINI SEFLLPLLLD SFQMASTPER EQLLKAQAQA CGMIKPESES
IRYLVTAVTF RDENGNNCTE HSHVHAVDTI LKKYIKYESF FLEDKIVSVL WSTPASFDKY
LHILADDIVQ SSARILNLRC SLGASRVVQG FTDLSEAYRD AVNAMRYAGR SGQGGVRYII
DEEPFSGVDM DYVMKVVANI EEKIRGGARE ELESYLWEVF GCLKDENNSR EKVNFMLVEI
LSCVCRIMYS MSAESDAAAL KADPFMQQMA FLDSSLKDAS EHFVHFCMAA RDRIAEHKTK
SSMDICDRAI RYIEDNYSNA DLSLMSASTE IGVSPNYLSA LIKKRTGNSF VDYLTKKRME
TAKILLLNTA MKIREVSEAC GYNDQHYFSY CFKKYEGVSP NMLRRQLTQE ERQA
//
