ID D4MUY6_ANAHA Unreviewed; 264 AA.
AC D4MUY6;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=5-proFAR isomerase {ECO:0000256|ARBA:ARBA00031376};
GN ORFNames=CL2_23430 {ECO:0000313|EMBL:CBL39202.1}, ERS852520_00103
GN {ECO:0000313|EMBL:CUO89449.1};
OS Anaerostipes hadrus.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Anaerostipes.
OX NCBI_TaxID=649756 {ECO:0000313|EMBL:CBL39202.1, ECO:0000313|Proteomes:UP000008960};
RN [1] {ECO:0000313|EMBL:CBL39202.1, ECO:0000313|Proteomes:UP000008960}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SSC/2 {ECO:0000313|EMBL:CBL39202.1,
RC ECO:0000313|Proteomes:UP000008960};
RG metaHIT consortium -- http://www.metahit.eu/;
RA Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT "The genome sequence of Clostridiales sp. SSC/2.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBL39202.1, ECO:0000313|Proteomes:UP000008960}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SSC/2 {ECO:0000313|EMBL:CBL39202.1,
RC ECO:0000313|Proteomes:UP000008960};
RA Pajon A.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CUO89449.1, ECO:0000313|Proteomes:UP000095564}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2789STDY5834908 {ECO:0000313|EMBL:CUO89449.1,
RC ECO:0000313|Proteomes:UP000095564};
RG Pathogen Informatics;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
CC -!- SIMILARITY: Belongs to the HisA/HisF family.
CC {ECO:0000256|ARBA:ARBA00009667, ECO:0000256|RuleBase:RU003657}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FP929061; CBL39202.1; -; Genomic_DNA.
DR EMBL; CZAU01000001; CUO89449.1; -; Genomic_DNA.
DR RefSeq; WP_015530703.1; NZ_CZAU01000001.1.
DR AlphaFoldDB; D4MUY6; -.
DR STRING; 649756.ERS852387_00095; -.
DR GeneID; 15232293; -.
DR KEGG; bprl:CL2_23430; -.
DR PATRIC; fig|245018.3.peg.2630; -.
DR OrthoDB; 9807749at2; -.
DR Proteomes; UP000008960; Chromosome.
DR Proteomes; UP000095564; Unassembled WGS sequence.
DR GO; GO:0003949; F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity; IEA:InterPro.
DR GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd04723; HisA_HisF; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR011858; His6-like_euk.
DR InterPro; IPR006062; His_biosynth.
DR InterPro; IPR044524; Isoase_HisA-like.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR NCBIfam; TIGR02129; hisA_euk; 1.
DR PANTHER; PTHR43090; 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE; 1.
DR PANTHER; PTHR43090:SF2; 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE; 1.
DR Pfam; PF00977; His_biosynth; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605,
KW ECO:0000256|RuleBase:RU003657};
KW Histidine biosynthesis {ECO:0000256|ARBA:ARBA00023102,
KW ECO:0000256|RuleBase:RU003657}; Isomerase {ECO:0000313|EMBL:CBL39202.1}.
SQ SEQUENCE 264 AA; 29762 MW; 6D83E104127CD322 CRC64;
MRFRPCIDIH NGKIKQIVGG SLLDQGDFAT ENFVSEKDGT FYGKLYKENH LNGGHIIMLN
ARDSKYYEED KVQALKALKA FEGGLQIGGG ITDENAKEFI ESGASHVIVT SFVFAGGKVH
YDRLDALKEQ VGREHLVLDL SCRKRNDKYY ITTDRWQKFT EEELTIELLH KLESWCDEYL
IHGVDVEGKA QGIDQELVQL LARYNGNKVT YAGGVKNFDD LELLKNYGND KIDVTIGSAL
DLFGGDMEFS KVLEYCDATI TNLN
//
