ID D4MXP9_ANAHA Unreviewed; 750 AA.
AC D4MXP9;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN Name=gyrA_2 {ECO:0000313|EMBL:CUN16129.1};
GN ORFNames=CL2_03040 {ECO:0000313|EMBL:CBL37394.1}, ERS852571_02907
GN {ECO:0000313|EMBL:CUN16129.1};
OS Anaerostipes hadrus.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Anaerostipes.
OX NCBI_TaxID=649756 {ECO:0000313|EMBL:CBL37394.1, ECO:0000313|Proteomes:UP000008960};
RN [1] {ECO:0000313|EMBL:CBL37394.1, ECO:0000313|Proteomes:UP000008960}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SSC/2 {ECO:0000313|EMBL:CBL37394.1,
RC ECO:0000313|Proteomes:UP000008960};
RG metaHIT consortium -- http://www.metahit.eu/;
RA Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT "The genome sequence of Clostridiales sp. SSC/2.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBL37394.1, ECO:0000313|Proteomes:UP000008960}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SSC/2 {ECO:0000313|EMBL:CBL37394.1,
RC ECO:0000313|Proteomes:UP000008960};
RA Pajon A.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CUN16129.1, ECO:0000313|Proteomes:UP000095553}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2789STDY5834959 {ECO:0000313|EMBL:CUN16129.1,
RC ECO:0000313|Proteomes:UP000095553};
RG Pathogen Informatics;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
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DR EMBL; FP929061; CBL37394.1; -; Genomic_DNA.
DR EMBL; CYXY01000024; CUN16129.1; -; Genomic_DNA.
DR RefSeq; WP_008392803.1; NZ_JAJCRN010000008.1.
DR AlphaFoldDB; D4MXP9; -.
DR STRING; 649756.ERS852387_01238; -.
DR GeneID; 15230485; -.
DR KEGG; bprl:CL2_03040; -.
DR PATRIC; fig|245018.3.peg.97; -.
DR Proteomes; UP000008960; Chromosome.
DR Proteomes; UP000095553; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 2.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:CBL37394.1};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 8..485
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT COILED 457..498
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 750 AA; 84969 MW; 1F8E16367D28BBAB CRC64;
MSEHIIKAEF SEVMQKSYID YAMSVICARA LPDARDGLKP VQRRVLYSMD ELGLRYDRPH
RKSARIVGDT MGKYHPHGDS SIYESLVVMS QDFKKGVPLV DGHGNFGSIE GDGAAAMRYT
EARLQKITQE AYLADLDKNV VDFVSNFDET EKEPEVLPVK VPNLLVNGAD GIAVGMTTSI
PPHNLGEVVD AVKAYMRKES ITNEELMEYI KGPDFPTGGL VINKKDLLNI YSSGTGKLKL
RGKVTFEPAK KRGEKDKLVI SEIPYTMIGN NISKFLSDTV ALIENKVTTD ILDISNESSK
DGIRIVLELR KGADVERLKN LLYKKTKLED TFGVNMLAIV DGRPETLDLK GIIENHTQFY
YEVTRRKYKT LLSKLYEQRE IKEGLIKACD MIDLIIEIIR GSKSQKEVKA CLTKGDVGNI
NFKSSDSMIE ATKLSFTDKQ ASAILDLKLY RLIGLEILML KEEYEEILAK IEEYEDILNN
EKSLKNVIRK ELDKIKKEFG RERRTVVEDG KEAVYVAAPV KEETVYFVMD RFGYSKTMDK
ATYQRNKENI LKEYKFIVPC MNTDKICIFT NLGVMHQIKV LDIPAGKFRD KGVPIDNLCN
YDSTKEYIIQ VLDAESMIHS SLLFATAKSM LKVMDGELLN AAKRTVQATK LSEDELIEVI
PIDWMEGSED KVVLQTKEGV FLKFLLSEIP KKKKSALGVR GMKLSKDDSL TNIYVMAAQN
ISSIVYKEKE LEFHRLKLSK RDSKGTKVRR
//
