ID D4YRW3_9LACO Unreviewed; 620 AA.
AC D4YRW3;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=Septation ring formation regulator EzrA {ECO:0000256|HAMAP-Rule:MF_00728};
GN Name=ezrA {ECO:0000256|HAMAP-Rule:MF_00728,
GN ECO:0000313|EMBL:EFG56057.1};
GN ORFNames=HMPREF0493_0241 {ECO:0000313|EMBL:EFG56057.1};
OS Lactobacillus amylolyticus DSM 11664.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=585524 {ECO:0000313|EMBL:EFG56057.1, ECO:0000313|Proteomes:UP000004069};
RN [1] {ECO:0000313|EMBL:EFG56057.1, ECO:0000313|Proteomes:UP000004069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11664 {ECO:0000313|EMBL:EFG56057.1,
RC ECO:0000313|Proteomes:UP000004069};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC formation at polar sites. Interacts either with FtsZ or with one of its
CC binding partners to promote depolymerization. {ECO:0000256|HAMAP-
CC Rule:MF_00728}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_00728};
CC Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_00728}.
CC Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Note=Colocalized with FtsZ to the
CC nascent septal site. {ECO:0000256|HAMAP-Rule:MF_00728}.
CC -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000256|HAMAP-
CC Rule:MF_00728}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFG56057.1}.
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DR EMBL; ADNY01000011; EFG56057.1; -; Genomic_DNA.
DR AlphaFoldDB; D4YRW3; -.
DR STRING; 83683.B1745_04180; -.
DR eggNOG; COG4477; Bacteria.
DR Proteomes; UP000004069; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005940; C:septin ring; IEA:InterPro.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR HAMAP; MF_00728; EzrA; 1.
DR InterPro; IPR010379; EzrA.
DR Pfam; PF06160; EzrA; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_00728};
KW Cell division {ECO:0000256|HAMAP-Rule:MF_00728};
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_00728};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|HAMAP-
KW Rule:MF_00728};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_00728};
KW Reference proteome {ECO:0000313|Proteomes:UP000004069};
KW Septation {ECO:0000256|ARBA:ARBA00023210, ECO:0000256|HAMAP-Rule:MF_00728};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_00728};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_00728}.
FT TOPO_DOM 1..56
FT /note="Extracellular"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT TRANSMEM 56..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TOPO_DOM 76..620
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT COILED 219..279
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT COILED 310..349
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT COILED 523..550
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
SQ SEQUENCE 620 AA; 72108 MW; C226110EE4BFE04C CRC64;
MLTFLSLIAA NILHEYYYKR QIRINQEKAR FYPVFSVFWY NYGSFGGYTM SSVQTLIIIA
IIILIILIVG FIIIQNRKHL HEIEAIDNSV DKIAKMHLER DIKRLDKMDL AGESLTTLNT
WRKCYQDAAT SKIPEVQHLL ELAADENASY HLFKARKNIK KAQEIINSTL DDMKNTHDVF
NDLLESNREN QLQYDALIKT YRSMRKNILA DSFNYGSALN QLENKLSSME SDFDEAKNLS
SQGDHVEAKR VLTKIKVALN ELKEQLPKIK EAEHQLETVF QDQLSELSDA YKKMISEKFY
INKVNVLDEI KKIHEEIDSA RNLLAGLKID ELDKENKKIA SQIDDLYNVL ATEYKARPFV
EENQSKMFTL ISHQQIASKK LVEKLRHIDE SYELTHGELD ESKHLEQEVN DMNRQYTVDT
QNIADGKGVY SEIQNSWLAM LDRLRQIDAE QKQMSQDVDG LYDSENVAND SIKHFKQEVS
LVYRRLQRRK LPGNPDSFVQ MYTLVVNEIG HVSEQLSEVR INMEKISNEL IQISDDVERL
KREADDIINS ANLVELTMQY SNKYSDRDAI QKAQDKAMKL YQRNYDYKNA LDTIATALEK
AEPGAYQRLE NSYYSEKNNK
//
