ID D4ZFC9_SHEVD Unreviewed; 539 AA.
AC D4ZFC9;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Aminopeptidase family {ECO:0000313|EMBL:BAJ04293.1};
GN OrderedLocusNames=SVI_4322 {ECO:0000313|EMBL:BAJ04293.1};
OS Shewanella violacea (strain JCM 10179 / CIP 106290 / LMG 19151 / DSS12).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Shewanellaceae; Shewanella.
OX NCBI_TaxID=637905 {ECO:0000313|EMBL:BAJ04293.1, ECO:0000313|Proteomes:UP000002350};
RN [1] {ECO:0000313|Proteomes:UP000002350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 10179 / CIP 106290 / LMG 19151 / DSS12
RC {ECO:0000313|Proteomes:UP000002350};
RX PubMed=20458400; DOI=10.1039/c000396d;
RA Aono E., Baba T., Ara T., Nishi T., Nakamichi T., Inamoto E., Toyonaga H.,
RA Hasegawa M., Takai Y., Okumura Y., Baba M., Tomita M., Kato C., Oshima T.,
RA Nakasone K., Mori H.;
RT "Complete genome sequence and comparative analysis of Shewanella violacea,
RT a psychrophilic and piezophilic bacterium from deep sea floor sediments.";
RL Mol. Biosyst. 6:1216-1226(2010).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR634015-3};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR634015-3};
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DR EMBL; AP011177; BAJ04293.1; -; Genomic_DNA.
DR AlphaFoldDB; D4ZFC9; -.
DR STRING; 637905.SVI_4322; -.
DR KEGG; svo:SVI_4322; -.
DR eggNOG; COG0308; Bacteria.
DR HOGENOM; CLU_014298_1_1_6; -.
DR Proteomes; UP000002350; Chromosome.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd09603; M1_APN_like; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR Gene3D; 2.60.40.1730; tricorn interacting facor f3 domain; 1.
DR InterPro; IPR045357; Aminopeptidase_N-like_N.
DR InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR InterPro; IPR014782; Peptidase_M1_dom.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR PANTHER; PTHR11533:SF303; AMINOPEPTIDASE N; 1.
DR PANTHER; PTHR11533; PROTEASE M1 ZINC METALLOPROTEASE; 1.
DR Pfam; PF01433; Peptidase_M1; 1.
DR Pfam; PF17900; Peptidase_M1_N; 1.
DR SUPFAM; SSF63737; Leukotriene A4 hydrolase N-terminal domain; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 4: Predicted;
KW Aminopeptidase {ECO:0000313|EMBL:BAJ04293.1};
KW Hydrolase {ECO:0000313|EMBL:BAJ04293.1};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR634015-3};
KW Protease {ECO:0000313|EMBL:BAJ04293.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002350};
KW Zinc {ECO:0000256|PIRSR:PIRSR634015-3}.
FT DOMAIN 37..210
FT /note="Aminopeptidase N-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17900"
FT DOMAIN 277..457
FT /note="Peptidase M1 membrane alanine aminopeptidase"
FT /evidence="ECO:0000259|Pfam:PF01433"
FT ACT_SITE 323
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR634015-1"
FT ACT_SITE 397
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR634015-1"
FT BINDING 322
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR634015-3"
FT BINDING 326
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR634015-3"
FT BINDING 345
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR634015-3"
SQ SEQUENCE 539 AA; 63165 MW; 85A356F815A60AF4 CRC64;
MQYDPKLLAD EQALPHPKDN IQWGSYRQHR ENNDLLSYDL TLKVDIDKRY LTGHNKIRFR
MLQRDDTIRI DLYKNLQIDK ISYKDQILEY ERDLNAVYIH FPAALELGSV NEIDFHYSGQ
PSTKGRFGCF TFKKDSRGLD WVNTACQGTG SMVWWPNKDQ QRDEVESMTM RISVPSHLKN
ISNGRLIATN ILADGYTEYV WQTNNPINNY SVSLNIGNYV HFGENLGELS LDYYVLEQDL
AKAKQQFTQV IPMMKSYQKH FGQYPFIQDG YKLIQAPYTG MEHQSAITYG NQFKNGYNRG
DGSDPDWTGV GISLKFDFII IHESGHEWFG NSLTSNDFSD AWIHEAWCTY AESVYVEDQF
GYPEAIKYIN GYKDKVKNRY PMIGPPSIGH WPTSDIYFKG TLFINTLRHI INDDKKWWDG
IRAFTSKFNR QNLDTLDVLN FFNNYFDRDF EKVFDQYLYF NQLPTLELYR SQDSIEYRWQ
ADVSDFTMPV PITLDGKKRK LLVTDSWQSL PLESEFKVNT DLVYINISRL TNRVKKTAI
//
