ID D5AQ90_RHOCB Unreviewed; 709 AA.
AC D5AQ90;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=methylmalonyl-CoA mutase {ECO:0000256|ARBA:ARBA00012398};
DE EC=5.4.99.2 {ECO:0000256|ARBA:ARBA00012398};
GN Name=bhbA {ECO:0000313|EMBL:ADE84677.1};
GN OrderedLocusNames=RCAP_rcc00912 {ECO:0000313|EMBL:ADE84677.1};
OS Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Rhodobacter.
OX NCBI_TaxID=272942 {ECO:0000313|EMBL:ADE84677.1, ECO:0000313|Proteomes:UP000002361};
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SB1003;
RA Strnad H., Lapidus A., Vlcek C., Ulbrich P., Paces J., Maltsev N.,
RA Kumar V., Kogan Y., Milgram A., Rebrekov D., Mazur M., Cox R., Kyrpides N.,
RA Kolar M., Sachova J., Ridl J., Ivanova N., Kapatral V., Los T., Lykidis A.,
RA Mikhailova N., Reznik G., Vasieva O., Fonstein M., Paces V., Haselkorn R.;
RT "Complete genome sequence of Rhodobacter capsulatus SB1003.";
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADE84677.1, ECO:0000313|Proteomes:UP000002361}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-309 / NBRC 16581 / SB1003
RC {ECO:0000313|Proteomes:UP000002361};
RX PubMed=20418398; DOI=10.1128/JB.00366-10;
RA Strnad H., Lapidus A., Paces J., Ulbrich P., Vlcek C., Paces V.,
RA Haselkorn R.;
RT "Complete genome sequence of the photosynthetic purple nonsulfur bacterium
RT Rhodobacter capsulatus SB 1003.";
RL J. Bacteriol. 192:3545-3546(2010).
CC -!- COFACTOR:
CC Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408;
CC Evidence={ECO:0000256|ARBA:ARBA00001922};
CC -!- SIMILARITY: Belongs to the methylmalonyl-CoA mutase family.
CC {ECO:0000256|ARBA:ARBA00008465}.
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DR EMBL; CP001312; ADE84677.1; -; Genomic_DNA.
DR RefSeq; WP_013066656.1; NC_014034.1.
DR AlphaFoldDB; D5AQ90; -.
DR STRING; 272942.RCAP_rcc00912; -.
DR GeneID; 31489849; -.
DR KEGG; rcp:RCAP_rcc00912; -.
DR eggNOG; COG1884; Bacteria.
DR eggNOG; COG2185; Bacteria.
DR HOGENOM; CLU_009523_3_1_5; -.
DR OrthoDB; 9762378at2; -.
DR Proteomes; UP000002361; Chromosome.
DR GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004494; F:methylmalonyl-CoA mutase activity; IEA:UniProtKB-EC.
DR CDD; cd02071; MM_CoA_mut_B12_BD; 1.
DR CDD; cd03679; MM_CoA_mutase_alpha_like; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.20.20.240; Methylmalonyl-CoA mutase; 1.
DR InterPro; IPR006159; Acid_CoA_mut_C.
DR InterPro; IPR016176; Cbl-dep_enz_cat.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR006099; MeMalonylCoA_mutase_a/b_cat.
DR InterPro; IPR006098; MMCoA_mutase_a_cat.
DR NCBIfam; TIGR00640; acid_CoA_mut_C; 1.
DR NCBIfam; TIGR00641; acid_CoA_mut_N; 1.
DR PANTHER; PTHR48101:SF4; METHYLMALONYL-COA MUTASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR48101; METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF01642; MM_CoA_mutase; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF51703; Cobalamin (vitamin B12)-dependent enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS00544; METMALONYL_COA_MUTASE; 1.
PE 3: Inferred from homology;
KW Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:ADE84677.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002361}.
FT DOMAIN 579..709
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
SQ SEQUENCE 709 AA; 76829 MW; D89DFAB998EB5EC0 CRC64;
MTDKIEGWRK LAEKELKGRA PESLTWNTLE GIAVKPLYTE ADTADLPHMG TLPGIAPFTR
GVRATMYAGR PWTIRQYAGF STAEESNAFY RKALAAGQQG VSVAFDLATH RGYDSDHPRV
VGDVGKAGVA IDSVEDMKIL FDGIPLEKVS VSMTMNGAVI PILANFIVTG EEQGVDRSLL
SGTIQNDILK EFMVRNTYIY PPEPSMRIIA DIIEYTSKEM PKFNSISISG YHMQEAGANL
VQELAYTLAD GREYVRAALA RGMNVDDFAG RLSFFFAIGM NFFMEAAKLR AARLLWHRIM
SEFEPKKPGS LMLRTHCQTS GVSLQEQDPY NNVIRTAYEA MSAALGGTQS LHTNALDEAI
ALPTEFSARI ARNTQIILQE ETGVTKVVDP LAGSYYVEAL TAELADKAWA LIEEVEAMGG
MTKAVATGMP KLRIEESAAR RQAAIDRGED VIVGVNKYRL AKEDPIDILD IDNVAVRESQ
IARLTQMRSS RDEAKCAAAL AEITRRAKEG GNLLEAAVDA ARARASVGEI SMAMEEIFGR
HRAEVKTLSG VYGAAYEGDA GFAQIQADVD AFAEAEGRRP RMLVVKMGQD GHDRGAKVIA
TAFADIGFDV DVGTLFQTPE EAAQDAVDND VHVVGISSLA AGHKTLAPKL IEALKEKGAE
DILVICGGVI PQQDYDFLKA AGVKAIFGPG TNIPAAAREI LDLIRAARG
//
