ID D5BRB8_PUNMI Unreviewed; 358 AA.
AC D5BRB8;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Cobalamin biosynthesis protein CobW {ECO:0000313|EMBL:ADE38815.1};
DE EC=3.6.-.- {ECO:0000313|EMBL:ADE38815.1};
GN OrderedLocusNames=SAR116_0572 {ECO:0000313|EMBL:ADE38815.1};
OS Puniceispirillum marinum (strain IMCC1322).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; SAR116 cluster;
OC Puniceispirillum.
OX NCBI_TaxID=488538 {ECO:0000313|EMBL:ADE38815.1, ECO:0000313|Proteomes:UP000007460};
RN [1] {ECO:0000313|EMBL:ADE38815.1, ECO:0000313|Proteomes:UP000007460}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IMCC1322 {ECO:0000313|EMBL:ADE38815.1,
RC ECO:0000313|Proteomes:UP000007460};
RX PubMed=20382761; DOI=10.1128/JB.00347-10;
RA Oh H.M., Kwon K.K., Kang I., Kang S.G., Lee J.H., Kim S.J., Cho J.C.;
RT "Complete genome sequence of "Candidatus Puniceispirillum marinum"
RT IMCC1322, a representative of the SAR116 clade in the
RT Alphaproteobacteria.";
RL J. Bacteriol. 192:3240-3241(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC subfamily. {ECO:0000256|ARBA:ARBA00034320}.
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DR EMBL; CP001751; ADE38815.1; -; Genomic_DNA.
DR RefSeq; WP_013045444.1; NC_014010.1.
DR AlphaFoldDB; D5BRB8; -.
DR STRING; 488538.SAR116_0572; -.
DR KEGG; apb:SAR116_0572; -.
DR eggNOG; COG0523; Bacteria.
DR HOGENOM; CLU_017452_1_0_5; -.
DR OrthoDB; 9808822at2; -.
DR Proteomes; UP000007460; Chromosome.
DR GO; GO:0003924; F:GTPase activity; IEA:RHEA.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:InterPro.
DR CDD; cd03112; CobW-like; 1.
DR Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR012824; CobW.
DR InterPro; IPR036627; CobW-likC_sf.
DR InterPro; IPR011629; CobW-like_C.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR02475; CobW; 1.
DR PANTHER; PTHR13748; COBW-RELATED; 1.
DR PANTHER; PTHR13748:SF70; PROTEIN COBW; 1.
DR Pfam; PF02492; cobW; 1.
DR Pfam; PF07683; CobW_C; 1.
DR SUPFAM; SSF90002; Hypothetical protein YjiA, C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:ADE38815.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007460}.
FT DOMAIN 7..202
FT /note="CobW/HypB/UreG nucleotide-binding"
FT /evidence="ECO:0000259|Pfam:PF02492"
FT DOMAIN 277..350
FT /note="CobW C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07683"
FT REGION 234..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 358 AA; 37885 MW; CD59347FFCE29361 CRC64;
MSQARIPATV ITGFLGSGKT TLIRNIIMQA NGKRLALIVN EFGDIGMDGD MLQECGADSC
RAEDIIELAN GCICCTVADD FLPSIQTLLA QDPPPDHIVI ETSGLALPQP LVQAFGWPDI
KSRVMLDGVV TLVDGPALAM GGIAHDLEAL EAQRAADAEL DHESPIDELF EDQISAANLI
VISKADMLDD DGAAKARTMV ERHLDEPTPI ISVAGGVAPM DAILGLDMED QAHARAEHAH
HHHHHHDDDP DHHHEHEHGH DEFASFIISM GSVDSAATFT AQLAELAGQH GILRAKGRLQ
EAGKALPLVV QAVGKRVDSY YARDTEARVG QLVVIGLAGL DGAAIASQLG GSLADASS
//
