ID D5C2H7_NITHN Unreviewed; 355 AA.
AC D5C2H7;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Na+/Ca+ antiporter, CaCA family {ECO:0000313|EMBL:ADE14836.1};
GN OrderedLocusNames=Nhal_1709 {ECO:0000313|EMBL:ADE14836.1};
OS Nitrosococcus halophilus (strain Nc4).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales; Chromatiaceae;
OC Nitrosococcus.
OX NCBI_TaxID=472759 {ECO:0000313|EMBL:ADE14836.1, ECO:0000313|Proteomes:UP000001844};
RN [1] {ECO:0000313|Proteomes:UP000001844}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nc4 {ECO:0000313|Proteomes:UP000001844};
RG US DOE Joint Genome Institute;
RA Campbell M.A., Malfatti S.A., Chain P.S.G., Heidelberg J.F., Ward B.B.,
RA Klotz M.G.;
RT "Complete genome sequence of Nitrosococcus halophilus Nc4, a salt-adapted,
RT aerobic obligate ammonia-oxidizing sulfur purple bacterium.";
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001798; ADE14836.1; -; Genomic_DNA.
DR RefSeq; WP_013032723.1; NC_013960.1.
DR AlphaFoldDB; D5C2H7; -.
DR STRING; 472759.Nhal_1709; -.
DR KEGG; nhl:Nhal_1709; -.
DR eggNOG; COG0530; Bacteria.
DR HOGENOM; CLU_007948_0_3_6; -.
DR OrthoDB; 9794225at2; -.
DR Proteomes; UP000001844; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 1.
DR InterPro; IPR004481; K/Na/Ca-exchanger.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00367; calcium/sodium antiporter; 1.
DR PANTHER; PTHR10846:SF8; INNER MEMBRANE PROTEIN YRBG; 1.
DR PANTHER; PTHR10846; SODIUM/POTASSIUM/CALCIUM EXCHANGER; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001844};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 69..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 276..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..145
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 173..316
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
SQ SEQUENCE 355 AA; 37563 MW; CD3620A5441A6953 CRC64;
MSSITVLLLV LGFILLMEGA EWLVRGAARL GANSGISPLA IGLTVVALGT SAPELAVNLQ
SALGGHPDIA VGNVIGSNIL NVLFILGISA LITPLSVSAP LIRLDVALML ATSSLVYLLA
LDGQFSRLDG GLLFIGMIIY LVFSTIKCRR ENMEVPHEYT EEYGLQKKGI LKSLGLILLG
LLLLALGARW LVAGAVEMAR FFGVSELIVG LTLIAIGTSL PEAAASVVAS LRGERDIAVG
NVVGSNLFNL LAVLGLTSLA TPAGIPISPA ALNFDIPVML AASIACLPIL FTSHLIARWE
GILFLGYYLA YTAYLLLYPL QHHDLETYNS TMLGFVIPLT AITLLVLVIR ARRKP
//
