ID D5C4S5_NITHN Unreviewed; 1854 AA.
AC D5C4S5;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN OrderedLocusNames=Nhal_0131 {ECO:0000313|EMBL:ADE13348.1};
OS Nitrosococcus halophilus (strain Nc4).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales; Chromatiaceae;
OC Nitrosococcus.
OX NCBI_TaxID=472759 {ECO:0000313|EMBL:ADE13348.1, ECO:0000313|Proteomes:UP000001844};
RN [1] {ECO:0000313|Proteomes:UP000001844}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nc4 {ECO:0000313|Proteomes:UP000001844};
RG US DOE Joint Genome Institute;
RA Campbell M.A., Malfatti S.A., Chain P.S.G., Heidelberg J.F., Ward B.B.,
RA Klotz M.G.;
RT "Complete genome sequence of Nitrosococcus halophilus Nc4, a salt-adapted,
RT aerobic obligate ammonia-oxidizing sulfur purple bacterium.";
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000}.
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DR EMBL; CP001798; ADE13348.1; -; Genomic_DNA.
DR RefSeq; WP_013031244.1; NC_013960.1.
DR STRING; 472759.Nhal_0131; -.
DR KEGG; nhl:Nhal_0131; -.
DR eggNOG; COG0178; Bacteria.
DR HOGENOM; CLU_001370_3_0_6; -.
DR OrthoDB; 9809851at2; -.
DR Proteomes; UP000001844; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-KW.
DR Gene3D; 3.30.190.20; -; 1.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 3.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR NCBIfam; TIGR00630; uvra; 2.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001844};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SOS response {ECO:0000256|ARBA:ARBA00023236};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 615..953
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1251..1479
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1854 AA; 204670 MW; 4DF1063674584269 CRC64;
MSKGFIWVKG ARQNNLKGLN LKFPLNELIV ITGVSGSGKS SLAFDTIYAE GQRRYVETFS
PYARQFLDRM DKPQVDRIEG IPPAIAIDQT NPVRTSRSTV GTMTELNDHL KLLFARAGKL
YCQGCGQPVR RDTPDSIYDQ LLHQGMGLRA LMTFEIAIPP NFSPQEVKEQ LLRQGYTRFH
HQNDQVLEVI QDRLRLEPSR RERIVEALET ALKHGRGRLA VYPLDEDRQP LPPWRFSSAL
HCPQCDLAYR DPFPNLFSFN SPLGACETCR GFGRTMGIDY DLVVPDDRKT LAEGAIKPWQ
TASYEECQQD LMRFARRRGI PTQRPWRELT SDQQRWVLEG EGEWEENKWY GVQRFFHWLE
GKSYKMHIRV LLSKYRAYHL CPACHGARLK PESLLWRLGT KADADRVLPE KHRFKPSGVR
FSQPQLAALP GLTLHDVMQL PLERCQQFFT QLTLPAPLDQ AAELLLGEIR SRLNYLVEVG
LGYLTLDRQS RTLSGGEVQR INLTTALGTS LVNTLFVLDE PSIGLHARDL QRIIRVLQRL
RDGGNSLIVV EHDPQVMLAA DRVLDLGPGP GERGGQRVFF GPPHELLQAK NSLTAQYLVG
KKQVVAEPSR AGKPPATASM EIRGATENNL KNITVRFPLN RLVCVTGVSG SGKSTLVQEV
LYKGLRKLKG QPVGIPGGHQ ALQGHEPIQG VVLVDQSPIG KTTRSNPVSY VGALAGLRKA
FAAEPLAQER GYGAGTFSFN SGNGRCPTCG GSGFEQVEMQ FLSDVYLRCP DCNGQRYRPE
ILEVKLQPST HSPGKSIAEV LEMTVAEALE FFADYPEVKR GIEPLQAVGL GYMKLGQPVP
TLSGGEAQRL KLAGHLAKGR GRKEAHRTLF LFDEPTTGLH FDDIATLLQA FQRLLAEGHS
LVVIEHNLEV IQAADWIIDL GPEGGEAGGK VIAIGSPQEV AQSQGSHTGQ ALRDHAQALN
LLTLATPAIG EAPSSYGAMF PEQARAEGNS AIYIHNAREH NLKGIELQIP RERFTVITGI
SGSGKSTVAF DILFAEGQRR YLESLNAYAR QFVQPAARPD LDAIFGIPPT VAIEQRTSRG
GLKSTVATLT EIYHFLRLLF VKLGQQHCPD CGIPIEAQTL EAIQARILRD YRGRRLSVLA
PLVVARKGYY TDLAKWAATK GFTHLRVDGT MIPTDPWPRL DRFKEHSIEL PVGEIKVTPG
EEKALGTLLE RALSLGQGRV EILLPKKGEK TLYSTKRSCP SCSRSFGELD PRLFSFNSPQ
GWCPRCYGTG QVLPGFDGSQ TGEEKEWAVG EENSARICPA CQGRRLWPDA LAVYFQERNI
AEFTGMSVAA AEATFQSMKL QGREAAIARD LLPELRSRLK FLKEVGLSYL TLDRAAPTLS
GGEAQRIRLA SQLGSNLRGV CYILDEPTIG LHPRDNKMLL NTLGKLEGKG NTIVVVEHDE
DTIRRAEHVI DLGPGAGVNG GRVVAAGTVE ALLHHPESVT GRCLAHPLPH PLMEKRRSEA
AECQLEIQGA SLHNLKHLDL CLPLGRLVGV TGVSGSGKST LVRQVIHGNL QRWLGVKGKT
QGKNAAFQGC EGIRGWEAIQ RVLEVDQTPI GKTPRSCPAT YVGFWDSIRR LFAETPEARI
RGYGPGRFSF NTKEGRCPEC EGQGVKKIEM SFLPDVTVPC EICHGARFTP ETLMIRYKDK
HIGEILAMSV DEATAFFSAH VWIHRPLQLL QAVGLGYLSL GQPSPTLSGG EAQRIKLVTE
LAKARSTPGR AGNHHTLYLL DEPTIGLHMA DVEKLIRVLH QLVEVGNTVM VIEHNLDIIA
EADWLVDLGP EGGDGGGRIV AQGTPEAVAR IKKGSHTAKF LAGFLRERRL KINK
//
