ID D5E4Y9_MYCCM Unreviewed; 741 AA.
AC D5E4Y9;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Ribonuclease R {ECO:0000256|HAMAP-Rule:MF_01895};
DE Short=RNase R {ECO:0000256|HAMAP-Rule:MF_01895};
DE EC=3.1.13.1 {ECO:0000256|HAMAP-Rule:MF_01895};
GN Name=vacB {ECO:0000313|EMBL:ADE19794.1};
GN Synonyms=rnr {ECO:0000256|HAMAP-Rule:MF_01895};
GN OrderedLocusNames=MCRO_0161 {ECO:0000313|EMBL:ADE19794.1};
OS Mycoplasma crocodyli (strain ATCC 51981 / MP145).
OC Bacteria; Mycoplasmatota; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=512564 {ECO:0000313|EMBL:ADE19794.1, ECO:0000313|Proteomes:UP000001845};
RN [1] {ECO:0000313|Proteomes:UP000001845}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51981 / MP145 {ECO:0000313|Proteomes:UP000001845};
RA Glass J.I., Durkin A.S., Hostetler J., Jackson J., Johnson J., May M.A.,
RA Paralanov V., Radune D., Szczypinski B., Brown D.R.;
RT "The complete genome of Mycoplasma crocodyli MP145.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MP145;
RA Ma Z., Wang X., Liu H.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ADE19794.1, ECO:0000313|Proteomes:UP000001845}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51981 / MP145 {ECO:0000313|Proteomes:UP000001845};
RX PubMed=21460083; DOI=10.1128/JB.00309-11;
RA Brown D.R., Farmerie W.G., May M., Benders G.A., Durkin A.S., Hlavinka K.,
RA Hostetler J., Jackson J., Johnson J., Miller R.H., Paralanov V., Radune D.,
RA Szczypinski B., Glass J.I.;
RT "Genome sequences of Mycoplasma alligatoris A21JP2T and Mycoplasma
RT crocodyli MP145T.";
RL J. Bacteriol. 193:2892-2893(2011).
CC -!- FUNCTION: 3'-5' exoribonuclease that releases 5'-nucleoside
CC monophosphates and is involved in maturation of structured RNAs.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC nucleoside 5'-phosphates.; EC=3.1.13.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001849, ECO:0000256|HAMAP-
CC Rule:MF_01895};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family. RNase R subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
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DR EMBL; CP001991; ADE19794.1; -; Genomic_DNA.
DR RefSeq; WP_013054570.1; NC_014014.1.
DR AlphaFoldDB; D5E4Y9; -.
DR STRING; 512564.MCRO_0161; -.
DR KEGG; mcd:MCRO_0161; -.
DR eggNOG; COG0557; Bacteria.
DR HOGENOM; CLU_002333_7_0_14; -.
DR OrthoDB; 9764149at2; -.
DR Proteomes; UP000001845; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008859; F:exoribonuclease II activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016070; P:RNA metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR HAMAP; MF_01895; RNase_R; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR004476; RNase_II/RNase_R.
DR InterPro; IPR011805; RNase_R.
DR InterPro; IPR003029; S1_domain.
DR NCBIfam; TIGR00358; 3_prime_RNase; 1.
DR NCBIfam; TIGR02063; RNase_R; 1.
DR PANTHER; PTHR23355:SF9; DIS3-LIKE EXONUCLEASE 2; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00955; RNB; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 2.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01895};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW Rule:MF_01895};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01895};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_01895};
KW Reference proteome {ECO:0000313|Proteomes:UP000001845};
KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_01895}.
FT DOMAIN 639..717
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
SQ SEQUENCE 741 AA; 85145 MW; 192034BF302E6530 CRC64;
MNIKEELLKY LQSSNEVRSF LSIAKGLNIK PNKNKELTKV LQECQQNFLI FKNEKDEYFA
PVFKEEIEGN ISISNNGKFA FVDYNINEEL NTKNSVFIIK NNFNGAIHND LVVVKIFEDI
TRNKEQRLFG VVSKIKQRMT NQLIGFVKQK GIYVDFEPID KKFKFNKYKI VGMKQQANLN
DLVTVKIEEI TKSFILVSIE KVITNDADTK LFIKAYLEGV NVPKIFPDSL ESEVSLIPQN
IDNENKENRE DFTNDLIVTI DGDDTKDFDD AINVVKLDNG NYLLSVHIAD VSYYVREGSK
INEEALKRGT SIYLADKVIP MLPEALSNGI CSLNPNEKRF VLSCIMEIDN SGKTVKTVIK
QGIIDSKYRL TYKQVNDFYD TQVIKNEWFS SNPNLNSKEF GVDNLSKMLN EAKELSLILH
KFKVNEGYID FEIQEPKILF NEDGSVKDIT FYPRGFSEEL IEDFMVRANE EVAKYLSGHH
FPAMYRVHEK PDEERLLSFR NVLSTLGVKV VLPIGQITPL IYSGIIEKIK EQRNDEFIKM
LFLRTMQKAV YSGDNLGHFG LASQCYCHFT SPIRRYPDLV IHRILRELVL NKDISKKEEL
TNLVFSVSKA NSASEQGAVE IERKVNDLLF SEYYKNKIGT VLKGQIVSVV KFGFFVEFEN
KTNALVHKSV LQDDTLEPND TMTQLKGKND TYTIGSYIDV VVAAVDLVDG KVDCVPQKFY
QDFLNQKINR RAVEDKHFRK N
//
