ID D5E8G4_METMS Unreviewed; 492 AA.
AC D5E8G4;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Radical SAM domain protein {ECO:0000313|EMBL:ADE37452.1};
GN OrderedLocusNames=Mmah_1957 {ECO:0000313|EMBL:ADE37452.1};
OS Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanohalophilus.
OX NCBI_TaxID=547558 {ECO:0000313|EMBL:ADE37452.1, ECO:0000313|Proteomes:UP000001059};
RN [1] {ECO:0000313|EMBL:ADE37452.1, ECO:0000313|Proteomes:UP000001059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35705 / DSM 5219 / SLP
RC {ECO:0000313|Proteomes:UP000001059};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA Lykidis A., Saunders E., Brettin T., Detter J.C., Han C., Land M.,
RA Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA Spring S., Schneider S., Schroeder M., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Methanohalophilus mahii DSM 5219.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP001994; ADE37452.1; -; Genomic_DNA.
DR RefSeq; WP_013038394.1; NC_014002.1.
DR AlphaFoldDB; D5E8G4; -.
DR STRING; 547558.Mmah_1957; -.
DR GeneID; 8984149; -.
DR KEGG; mmh:Mmah_1957; -.
DR HOGENOM; CLU_023791_0_0_2; -.
DR OrthoDB; 49555at2157; -.
DR Proteomes; UP000001059; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034471; GDGT/MA_synthase.
DR InterPro; IPR034474; Methyltransferase_Class_D.
DR InterPro; IPR007197; rSAM.
DR PANTHER; PTHR43306; 7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN DIMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR43306:SF1; 7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN DIMETHYLTRANSFERASE; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00385; 7_8-dihydro-6-hydroxymethylpte; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SFLD; SFLDG01067; SPASM/twitch_domain_containing; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001059};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 82..312
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 492 AA; 55628 MW; 57F5FB0675B7D258 CRC64;
MHNTKSVCPE CKKIIEATVF ENNGRVLMGK ECPEHGKFEE VYWSDANLYR KFQKYQHEGT
GVSNPLTSGD AGCPLSCGLC PSHKTTTLLA NIDVTNRCNL NCPICFANAK TRGFIYEPSF
QQIEDMLKIL REEKPTPCAA IQFSGGEPTV RDDLPAMIQK AKELGFVQIQ IATNGVRIAK
DIAFARKLKN AGLHTIYLSF DGVKEETYQK IRNFNALPIK KKAIDNCREA GIQSIVLVPT
LVKGENDDQL AEIIRFATDK LDVVKGINFQ PVAFTGRIDR QSREKQRFTI PDLIKGLADQ
TYGEVPEKAW YPIPFVVPIS RFIEGIQGKY LPEFTVHPHC GAATYLFVEK DRIIPITDFL
DVEGFIELLD NATKDLNGTK TRNLINLARV VREIPKLVDQ EKAPKSINVT KMLINIIKEG
EKEVASQFHR KSLFVGAMHF QDLYNFDLER VCRCGIHYAT PDGRIIPFCS YNTFHRDEVE
GQFLKPYNLN AK
//
