ID D5E9G0_METMS Unreviewed; 342 AA.
AC D5E9G0;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Methylamine-specific methylcobalamin:coenzyme M methyltransferase {ECO:0000313|EMBL:ADE35811.1};
GN OrderedLocusNames=Mmah_0279 {ECO:0000313|EMBL:ADE35811.1};
OS Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanohalophilus.
OX NCBI_TaxID=547558 {ECO:0000313|EMBL:ADE35811.1, ECO:0000313|Proteomes:UP000001059};
RN [1] {ECO:0000313|EMBL:ADE35811.1, ECO:0000313|Proteomes:UP000001059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35705 / DSM 5219 / SLP
RC {ECO:0000313|Proteomes:UP000001059};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA Lykidis A., Saunders E., Brettin T., Detter J.C., Han C., Land M.,
RA Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA Spring S., Schneider S., Schroeder M., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Methanohalophilus mahii DSM 5219.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR EMBL; CP001994; ADE35811.1; -; Genomic_DNA.
DR RefSeq; WP_013036754.1; NC_014002.1.
DR AlphaFoldDB; D5E9G0; -.
DR STRING; 547558.Mmah_0279; -.
DR GeneID; 8982411; -.
DR KEGG; mmh:Mmah_0279; -.
DR HOGENOM; CLU_040933_2_1_2; -.
DR OrthoDB; 124836at2157; -.
DR Proteomes; UP000001059; Chromosome.
DR GO; GO:0043791; F:dimethylamine methyltransferase activity; IEA:InterPro.
DR GO; GO:0004853; F:uroporphyrinogen decarboxylase activity; IEA:InterPro.
DR GO; GO:2001129; P:methane biosynthetic process from dimethylamine; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:InterPro.
DR GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:InterPro.
DR CDD; cd03307; Mta_CmuA_like; 1.
DR Gene3D; 3.20.20.210; -; 1.
DR InterPro; IPR048096; Methylcob_mtaseMtbA.
DR InterPro; IPR006360; Mtase_MtaA_CmuA.
DR InterPro; IPR038071; UROD/MetE-like_sf.
DR InterPro; IPR000257; Uroporphyrinogen_deCOase.
DR NCBIfam; NF041608; methylcob_mtaseMtbA; 1.
DR NCBIfam; TIGR01463; mtaA_cmuA; 1.
DR PANTHER; PTHR47099; METHYLCOBAMIDE:COM METHYLTRANSFERASE MTBA; 1.
DR PANTHER; PTHR47099:SF1; METHYLCOBAMIDE:COM METHYLTRANSFERASE MTBA; 1.
DR Pfam; PF01208; URO-D; 1.
DR SUPFAM; SSF51726; UROD/MetE-like; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methanogenesis {ECO:0000256|ARBA:ARBA00022994};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ADE35811.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001059};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ADE35811.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 5..340
FT /note="Uroporphyrinogen decarboxylase (URO-D)"
FT /evidence="ECO:0000259|Pfam:PF01208"
SQ SEQUENCE 342 AA; 37271 MW; EFF26B43B3EB9A4A CRC64;
MVEYTPKERL ARVFEGKEVD RMPAICATQT GTVEQMDAVG AYWPEAHEDP VKMAALAEAG
HTVVGFEAVR VPFDITAEAE FFGCGIKPST KEQQPSVISH VVSKAEDLEQ FEGYNIEDGR
IGNVCEAVKI LSDKYGDELP IIGSMIGPFS LAQHLNGDSW FMNIMTDQEF GLKLMEFTTE
FCTQYALKQV ENGADTFAII DPTASYQLIG ADFYKTFVVP FHQKIVEALH EKGIPSILHI
CGDTTNGLAI METCGVDAIS VDQNVDPAAA VENVDKALIL GNLDPVSVLW NQGEDNVEGV
KEESKNVLDA GVQLLAPGCG IVSKTPTQNL QAMIEAAKNW TY
//
