ID D5EW93_PRER2 Unreviewed; 754 AA.
AC D5EW93;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Cation transporter, monovalent cation:proton antiporter-2 (CPA2) family {ECO:0000313|EMBL:ADE81519.1};
GN OrderedLocusNames=PRU_0257 {ECO:0000313|EMBL:ADE81519.1};
OS Prevotella ruminicola (strain ATCC 19189 / JCM 8958 / 23).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Xylanibacter.
OX NCBI_TaxID=264731 {ECO:0000313|EMBL:ADE81519.1, ECO:0000313|Proteomes:UP000000927};
RN [1] {ECO:0000313|EMBL:ADE81519.1, ECO:0000313|Proteomes:UP000000927}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19189 / JCM 8958 / 23 {ECO:0000313|Proteomes:UP000000927};
RX PubMed=20585943; DOI=10.1007/s00248-010-9692-8;
RG North American Consortium for Rumen Bacteria;
RA Purushe J., Fouts D.E., Morrison M., White B.A., Mackie R.I.,
RA Coutinho P.M., Henrissat B., Nelson K.E.;
RT "Comparative genome analysis of Prevotella ruminicola and Prevotella
RT bryantii: insights into their environmental niche.";
RL Microb. Ecol. 60:721-729(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002006; ADE81519.1; -; Genomic_DNA.
DR RefSeq; WP_013063506.1; NC_014033.1.
DR AlphaFoldDB; D5EW93; -.
DR STRING; 264731.PRU_0257; -.
DR KEGG; pru:PRU_0257; -.
DR eggNOG; COG0475; Bacteria.
DR eggNOG; COG0490; Bacteria.
DR eggNOG; COG3273; Bacteria.
DR HOGENOM; CLU_020579_0_0_10; -.
DR Proteomes; UP000000927; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 2.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR PANTHER; PTHR42751:SF3; NA(+)_H(+) ANTIPORTER; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02080; TrkA_C; 2.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 2.
DR PROSITE; PS51202; RCK_C; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000927};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 32..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 427..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..523
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 529..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 583..667
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
FT DOMAIN 671..754
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 754 AA; 83735 MW; 3F55124D0BB46C5C CRC64;
MAELPPMIAD LALILMVAGV VTLIFKRLKQ PLVLGYIVAG FLVSPNMTYT PSAVDMANVH
LWADIGVMFL LFSLGLDFSF KKILKMGASP VISAITIIFC MMMLGIVVGH VFGWGKMDCI
FLGGMLAMSS TTIIYKAFDD LGLRQQQFAG MVMSVLILED ILAIVMMVML SALASGSDMG
GGQLLQSVMR IGFFLILWLV VGIFAIPLFL RRVRRLINNE VLLIVALGLC CAMAVFSTKV
GFSSAFGAFI MGSILAETIE AERIEKLVEP VKNLFGAVFF VSVGMLVDPK ILVEYAIPIL
CLVLTIIVGQ SVFGTISFML GGQSLKSAMR CGFSMAQIGE FSFIIASLGL SLGVIGDFLY
PVVVAVSVIT TFLTPYMIRL ATPAYNNLEK RLPGKLIKSL NQLAMGNTHS QEESKWKRLL
TQMTINTIVY SILSSASIAM MFAFVLPVTR KMLPGWELHW YANAITGVLT VALIAPFLRA
MVMKKNHSEE WKALWAESNR NRLPLLFTIL VRFLIAVSFI FYICNFLSRF TNALMITIGF
VVIVLIILSR RTKHRSITLE RLFIQNLRSR DIEAQVHGKK RPLYEGKLLD RDIHIADFTV
PFNSTWMGQS LSQLKLGTKY GVHVSSILRG GRRINIPDGY NILFPGDVLQ VIGSDQQFTA
FRDAIENEVL GIDVDVEMRE MKLRQLIIGT DSPFVGQTLI ESRIRDRFSC MVVGLEEGKE
SLSPYSPNRK FRAGDIIWVV GEQDSLDALF NIKD
//
