ID D5GXS0_LACCS Unreviewed; 563 AA.
AC D5GXS0;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=Rqc2 homolog RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
DE Short=RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN Name=rqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN OrderedLocusNames=LCRIS_01132 {ECO:0000313|EMBL:CBL50579.1};
OS Lactobacillus crispatus (strain ST1).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=748671 {ECO:0000313|EMBL:CBL50579.1, ECO:0000313|Proteomes:UP000002371};
RN [1] {ECO:0000313|EMBL:CBL50579.1, ECO:0000313|Proteomes:UP000002371}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ST1 {ECO:0000313|EMBL:CBL50579.1,
RC ECO:0000313|Proteomes:UP000002371};
RX PubMed=20435723; DOI=10.1128/JB.00399-10;
RA Ojala T., Kuparinen V., Koskinen J.P., Alatalo E., Holm L., Auvinen P.,
RA Edelman S., Westerlund-Wikstrom B., Korhonen T.K., Paulin L., Kankainen M.;
RT "Genome sequence of Lactobacillus crispatus ST1.";
RL J. Bacteriol. 192:3547-3548(2010).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ST1;
RA Ojala T., Kuparinen V., Koskinen J.P., Alatalo E., Holm L., Auvinen P.,
RA Edelman S., Westerlund-Wikstroem B., Korhonen T.K., Paulin L.,
RA Kankainen M.;
RT "Genome Sequence of Lactobacillus crispatus ST1.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the ribosome quality control system (RQC). Recruits
CC Ala-charged tRNA and directs the elongation of stalled nascent chains
CC on 50S ribosomal subunits, leading to non-templated C-terminal Ala
CC extensions (Ala tail). The Ala tail promotes nascent chain degradation.
CC May add between 1 and at least 8 Ala residues. Binds to stalled 50S
CC ribosomal subunits. {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SUBUNIT: Associates with stalled 50S ribosomal subunits.
CC {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SIMILARITY: Belongs to the NEMF family. {ECO:0000256|HAMAP-
CC Rule:MF_00844}.
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DR EMBL; FN692037; CBL50579.1; -; Genomic_DNA.
DR RefSeq; WP_013086379.1; NC_014106.1.
DR AlphaFoldDB; D5GXS0; -.
DR KEGG; lcr:LCRIS_01132; -.
DR PATRIC; fig|748671.3.peg.1107; -.
DR eggNOG; COG1293; Bacteria.
DR HOGENOM; CLU_022481_2_1_9; -.
DR OMA; SWHPQAA; -.
DR Proteomes; UP000002371; Chromosome.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProtKB-UniRule.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR HAMAP; MF_00844_B; RqcH_B; 1.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR InterPro; IPR043682; RqcH_bacterial.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF18297; NFACT-R_2; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|HAMAP-Rule:MF_00844};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_00844};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00844};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|HAMAP-
KW Rule:MF_00844}.
FT DOMAIN 445..533
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
FT COILED 289..316
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00844"
SQ SEQUENCE 563 AA; 65386 MW; 84394062CBAA430F CRC64;
MAFDGLFIHS LLKDLVPTLV GGRLSKIYQP FDQDLVLIFR KDRKNYQFLI SANAQYPRMY
LTKQNIANPD KAPIFVMVLR KYLEGSVLQS IEQVGLGRIV NFHFSNRNEL GDQVKLMLSV
ELMGRHSNVI LYNQEDNHII DLLKRINPDE NRARVLLPKA KYELPPLKPG LNGLTLSESE
FKQLSSENQP NEIAQKMDGL DKDDRTELLG YLEDDYTYSS FKTFFNQFDN PRAFILKTPR
NKRKIFCYLP YHLDLEKESS NPDLNAGLDE FYEYQATRDW VKQRAGQVER VVKNEQNKLT
KKVKKLEKQL DLAENSEGYR IKGEILNANL AQVKPGMTKV SLPNYYENNA PLEIKLDPAL
SPARNAQKYF TRYKKLRDSI KHINEQLRIA KDDIRYFDSI QTAIDNADPQ DIDQITDELI
NQGYLRKQKK NKRRKKITER NLNEFKLSSG KHVLVGKNNY QNDWLTLKKA NKSDYWFHVK
NMPGSHVILR DDQPTDQDIK EAAEIAAYFS KAKNSAHVQV DYVQDKRVKK PNGAKPGFVI
YTGQNSIEVT PEEKEIMNKK IEK
//