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Database: UniProt
Entry: D5GXS0_LACCS
LinkDB: D5GXS0_LACCS
Original site: D5GXS0_LACCS 
ID   D5GXS0_LACCS            Unreviewed;       563 AA.
AC   D5GXS0;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   RecName: Full=Rqc2 homolog RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
DE            Short=RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN   Name=rqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN   OrderedLocusNames=LCRIS_01132 {ECO:0000313|EMBL:CBL50579.1};
OS   Lactobacillus crispatus (strain ST1).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=748671 {ECO:0000313|EMBL:CBL50579.1, ECO:0000313|Proteomes:UP000002371};
RN   [1] {ECO:0000313|EMBL:CBL50579.1, ECO:0000313|Proteomes:UP000002371}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ST1 {ECO:0000313|EMBL:CBL50579.1,
RC   ECO:0000313|Proteomes:UP000002371};
RX   PubMed=20435723; DOI=10.1128/JB.00399-10;
RA   Ojala T., Kuparinen V., Koskinen J.P., Alatalo E., Holm L., Auvinen P.,
RA   Edelman S., Westerlund-Wikstrom B., Korhonen T.K., Paulin L., Kankainen M.;
RT   "Genome sequence of Lactobacillus crispatus ST1.";
RL   J. Bacteriol. 192:3547-3548(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ST1;
RA   Ojala T., Kuparinen V., Koskinen J.P., Alatalo E., Holm L., Auvinen P.,
RA   Edelman S., Westerlund-Wikstroem B., Korhonen T.K., Paulin L.,
RA   Kankainen M.;
RT   "Genome Sequence of Lactobacillus crispatus ST1.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the ribosome quality control system (RQC). Recruits
CC       Ala-charged tRNA and directs the elongation of stalled nascent chains
CC       on 50S ribosomal subunits, leading to non-templated C-terminal Ala
CC       extensions (Ala tail). The Ala tail promotes nascent chain degradation.
CC       May add between 1 and at least 8 Ala residues. Binds to stalled 50S
CC       ribosomal subunits. {ECO:0000256|HAMAP-Rule:MF_00844}.
CC   -!- SUBUNIT: Associates with stalled 50S ribosomal subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00844}.
CC   -!- SIMILARITY: Belongs to the NEMF family. {ECO:0000256|HAMAP-
CC       Rule:MF_00844}.
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DR   EMBL; FN692037; CBL50579.1; -; Genomic_DNA.
DR   RefSeq; WP_013086379.1; NC_014106.1.
DR   AlphaFoldDB; D5GXS0; -.
DR   KEGG; lcr:LCRIS_01132; -.
DR   PATRIC; fig|748671.3.peg.1107; -.
DR   eggNOG; COG1293; Bacteria.
DR   HOGENOM; CLU_022481_2_1_9; -.
DR   OMA; SWHPQAA; -.
DR   Proteomes; UP000002371; Chromosome.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR   HAMAP; MF_00844_B; RqcH_B; 1.
DR   InterPro; IPR008532; NFACT_RNA-bd.
DR   InterPro; IPR043682; RqcH_bacterial.
DR   PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR   PANTHER; PTHR15239:SF6; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR   Pfam; PF05670; NFACT-R_1; 1.
DR   Pfam; PF18297; NFACT-R_2; 1.
DR   Pfam; PF05833; NFACT_N; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|HAMAP-Rule:MF_00844};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW   Rule:MF_00844};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW   Rule:MF_00844};
KW   tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|HAMAP-
KW   Rule:MF_00844}.
FT   DOMAIN          445..533
FT                   /note="NFACT RNA-binding"
FT                   /evidence="ECO:0000259|Pfam:PF05670"
FT   COILED          289..316
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00844"
SQ   SEQUENCE   563 AA;  65386 MW;  84394062CBAA430F CRC64;
     MAFDGLFIHS LLKDLVPTLV GGRLSKIYQP FDQDLVLIFR KDRKNYQFLI SANAQYPRMY
     LTKQNIANPD KAPIFVMVLR KYLEGSVLQS IEQVGLGRIV NFHFSNRNEL GDQVKLMLSV
     ELMGRHSNVI LYNQEDNHII DLLKRINPDE NRARVLLPKA KYELPPLKPG LNGLTLSESE
     FKQLSSENQP NEIAQKMDGL DKDDRTELLG YLEDDYTYSS FKTFFNQFDN PRAFILKTPR
     NKRKIFCYLP YHLDLEKESS NPDLNAGLDE FYEYQATRDW VKQRAGQVER VVKNEQNKLT
     KKVKKLEKQL DLAENSEGYR IKGEILNANL AQVKPGMTKV SLPNYYENNA PLEIKLDPAL
     SPARNAQKYF TRYKKLRDSI KHINEQLRIA KDDIRYFDSI QTAIDNADPQ DIDQITDELI
     NQGYLRKQKK NKRRKKITER NLNEFKLSSG KHVLVGKNNY QNDWLTLKKA NKSDYWFHVK
     NMPGSHVILR DDQPTDQDIK EAAEIAAYFS KAKNSAHVQV DYVQDKRVKK PNGAKPGFVI
     YTGQNSIEVT PEEKEIMNKK IEK
//
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