ID   D5GZ99_LACCS            Unreviewed;       460 AA.
AC   D5GZ99;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=Aldehyde dehydrogenase {ECO:0000313|EMBL:CBL51108.1};
GN   Name=gabD {ECO:0000313|EMBL:CBL51108.1};
GN   OrderedLocusNames=LCRIS_01661 {ECO:0000313|EMBL:CBL51108.1};
OS   Lactobacillus crispatus (strain ST1).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=748671 {ECO:0000313|EMBL:CBL51108.1, ECO:0000313|Proteomes:UP000002371};
RN   [1] {ECO:0000313|EMBL:CBL51108.1, ECO:0000313|Proteomes:UP000002371}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ST1 {ECO:0000313|EMBL:CBL51108.1,
RC   ECO:0000313|Proteomes:UP000002371};
RX   PubMed=20435723; DOI=10.1128/JB.00399-10;
RA   Ojala T., Kuparinen V., Koskinen J.P., Alatalo E., Holm L., Auvinen P.,
RA   Edelman S., Westerlund-Wikstrom B., Korhonen T.K., Paulin L., Kankainen M.;
RT   "Genome sequence of Lactobacillus crispatus ST1.";
RL   J. Bacteriol. 192:3547-3548(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ST1;
RA   Ojala T., Kuparinen V., Koskinen J.P., Alatalo E., Holm L., Auvinen P.,
RA   Edelman S., Westerlund-Wikstroem B., Korhonen T.K., Paulin L.,
RA   Kankainen M.;
RT   "Genome Sequence of Lactobacillus crispatus ST1.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FN692037; CBL51108.1; -; Genomic_DNA.
DR   RefSeq; WP_013086801.1; NC_014106.1.
DR   AlphaFoldDB; D5GZ99; -.
DR   KEGG; lcr:LCRIS_01661; -.
DR   PATRIC; fig|748671.3.peg.1633; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_1_0_9; -.
DR   Proteomes; UP000002371; Chromosome.
DR   GO; GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IEA:InterPro.
DR   CDD; cd07100; ALDH_SSADH1_GabD1; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR044148; ALDH_GabD1-like.
DR   InterPro; IPR047110; GABD/Sad-like.
DR   PANTHER; PTHR43217; SUCCINATE SEMIALDEHYDE DEHYDROGENASE [NAD(P)+] SAD; 1.
DR   PANTHER; PTHR43217:SF2; SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP(+)]; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345}.
FT   DOMAIN          3..448
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        229
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   460 AA;  50743 MW;  BDABDA00FA75B018 CRC64;
     MSRYQSINPY TNEEFASYDN STAAQIDDAI NLAHALYKKW RHENPETRSR QLHKIADALR
     EHEDDLAKMM TLEMGKLLRE SREEVELCAS ICDYYAKNGV KMLAPTPIES DLGNAYYLKQ
     STGVIMACEP WNFPLYQVIR VFAPNFIVGN PILLKHAHNV PGSAALTAKI IRRAGAPEGS
     LINLYPTYDQ LSDIIADPRV QGVALTGSER GGSAVAEAAG KNLKKSTMEL GGNDAFIVLD
     DADLQVLRNV LGDARTYNDG QVCTSSKRII VEKSHYEEVL HTLKNVFSNL QAGDPLEADT
     TLPPMNSERA KEKLEAQVKK AVDAGAEIFY QYPEIDSKGA FFRPVILTNI DKENPIYDEE
     LFGPVAEVFV VDDDDDAIQL ANDSSYGLGS SVISNDIERA QNVAAQIETG MTVINGRWIT
     SGELPFGGVK KSGYGRELSD LGMMAFVNEH LVIDVTKNNQ
//