ID D5H069_LACCS Unreviewed; 912 AA.
AC D5H069;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 24-JAN-2024, entry version 78.
DE RecName: Full=Phosphoenolpyruvate carboxylase {ECO:0000256|ARBA:ARBA00022419, ECO:0000256|HAMAP-Rule:MF_00595};
DE Short=PEPC {ECO:0000256|HAMAP-Rule:MF_00595};
DE Short=PEPCase {ECO:0000256|HAMAP-Rule:MF_00595};
DE EC=4.1.1.31 {ECO:0000256|ARBA:ARBA00012305, ECO:0000256|HAMAP-Rule:MF_00595};
GN Name=ppc {ECO:0000256|HAMAP-Rule:MF_00595,
GN ECO:0000313|EMBL:CBL51428.1};
GN OrderedLocusNames=LCRIS_01981 {ECO:0000313|EMBL:CBL51428.1};
OS Lactobacillus crispatus (strain ST1).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=748671 {ECO:0000313|EMBL:CBL51428.1, ECO:0000313|Proteomes:UP000002371};
RN [1] {ECO:0000313|EMBL:CBL51428.1, ECO:0000313|Proteomes:UP000002371}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ST1 {ECO:0000313|EMBL:CBL51428.1,
RC ECO:0000313|Proteomes:UP000002371};
RX PubMed=20435723; DOI=10.1128/JB.00399-10;
RA Ojala T., Kuparinen V., Koskinen J.P., Alatalo E., Holm L., Auvinen P.,
RA Edelman S., Westerlund-Wikstrom B., Korhonen T.K., Paulin L., Kankainen M.;
RT "Genome sequence of Lactobacillus crispatus ST1.";
RL J. Bacteriol. 192:3547-3548(2010).
CC -!- FUNCTION: Forms oxaloacetate, a four-carbon dicarboxylic acid source
CC for the tricarboxylic acid cycle. {ECO:0000256|ARBA:ARBA00003670,
CC ECO:0000256|HAMAP-Rule:MF_00595}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=oxaloacetate + phosphate = hydrogencarbonate +
CC phosphoenolpyruvate; Xref=Rhea:RHEA:28370, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:17544, ChEBI:CHEBI:43474, ChEBI:CHEBI:58702; EC=4.1.1.31;
CC Evidence={ECO:0000256|ARBA:ARBA00001071, ECO:0000256|HAMAP-
CC Rule:MF_00595};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946,
CC ECO:0000256|HAMAP-Rule:MF_00595};
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00595}.
CC -!- SIMILARITY: Belongs to the PEPCase type 1 family.
CC {ECO:0000256|ARBA:ARBA00008346, ECO:0000256|HAMAP-Rule:MF_00595}.
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DR EMBL; FN692037; CBL51428.1; -; Genomic_DNA.
DR RefSeq; WP_013087066.1; NC_014106.1.
DR AlphaFoldDB; D5H069; -.
DR KEGG; lcr:LCRIS_01981; -.
DR PATRIC; fig|748671.3.peg.1941; -.
DR eggNOG; COG2352; Bacteria.
DR HOGENOM; CLU_006557_2_0_9; -.
DR OMA; PWVFGWT; -.
DR Proteomes; UP000002371; Chromosome.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015977; P:carbon fixation; IEA:UniProtKB-UniRule.
DR GO; GO:0006107; P:oxaloacetate metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR Gene3D; 1.20.1440.90; Phosphoenolpyruvate/pyruvate domain; 1.
DR HAMAP; MF_00595; PEPcase_type1; 1.
DR InterPro; IPR021135; PEP_COase.
DR InterPro; IPR022805; PEP_COase_bac/pln-type.
DR InterPro; IPR018129; PEP_COase_Lys_AS.
DR InterPro; IPR033129; PEPCASE_His_AS.
DR InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR PANTHER; PTHR30523; PHOSPHOENOLPYRUVATE CARBOXYLASE; 1.
DR PANTHER; PTHR30523:SF6; PHOSPHOENOLPYRUVATE CARBOXYLASE; 1.
DR Pfam; PF00311; PEPcase; 1.
DR PRINTS; PR00150; PEPCARBXLASE.
DR SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
DR PROSITE; PS00781; PEPCASE_1; 1.
DR PROSITE; PS00393; PEPCASE_2; 1.
PE 3: Inferred from homology;
KW Carbon dioxide fixation {ECO:0000256|ARBA:ARBA00023300, ECO:0000256|HAMAP-
KW Rule:MF_00595};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_00595};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|HAMAP-Rule:MF_00595};
KW Pyruvate {ECO:0000313|EMBL:CBL51428.1}.
FT ACT_SITE 138
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00595,
FT ECO:0000256|PROSITE-ProRule:PRU10111"
FT ACT_SITE 575
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00595,
FT ECO:0000256|PROSITE-ProRule:PRU10112"
SQ SEQUENCE 912 AA; 104429 MW; CC7A8A588E95EE1E CRC64;
MTVKKLENNS DVNVVAEESK VLTNLLNEST KQVIGQAAFD KIQNLIKISA AKDYQELEKQ
IASLNNREMI VVARYFATLP LLINISEDVE LASKVNVLNN THQDYLGKLS DTIDIVAQKK
NAEEILEHVN VVPVLTAHPT QVQRKTILEL TDQIHQLLRN YRDVKNGTID RDEWTEQMRA
CIEILMQTDI IRGHKLKVAN EITNVLAYYP KALIPAITKF TSRYKELAKK HGLNASHATP
ITMGMWIGGD RDGNPYVTAD TLELSATLQS QVIFEYYIKQ INKLYRAISM STSYMEPSDD
VMHLSELSND DSPFRTNEPY RRAFYYIQSR LVHTEQKLLN ITNKNTFLKK RDLQNLDKIP
CYQNAQEFKA DLEIIKNSLE EDHDHAVVDS YFTQILEAIN IFGFHLATID MRQDSSVNEA
CVAELLKSAG ICDNYSDLSE DKKIKLLLNE LNNDPRNLHA NNKPKSELLQ KELKIYKTAR
QLKDRLGEDV IKQHIISHTE SVSDMLEQAI MLKEYDLLDN QKARIQVVPL FETVEDLNNA
REIIKEFLSF DIVKKWLVSQ NNYQEVMLGY SDSNKDGGYL ASCWNLYKAQ KDLTKIGEEM
GIKITFMHGR GGTVGRGGGP SYEAITAQPF KSINDRMRMT EQGEIIQNKY GNKDTAYYNL
EMLASATIDR MASKQIVSED HVADFRSSMD QIVAKSNEVY RKLVFENPNF LKYFFQATPI
KEISGLNVGS RPASRKKLTD FSGLRAIPWV FSWSQSRVMF PGWYGVGSGF KSFIDADPAN
LKELQNMYQG WPFFHSLLSN VDMVLSKSNM RIAKQYADLC EDEQIKSVFD IINQEWELTK
KVILQIEGHD ELIEDAPTLK KSLEYRMPYF NILNYIQLEM IKRDREDEIQ GVYQSIIPIT
INGVASGLRN SG
//