ID D5J710_9NOST Unreviewed; 2565 AA.
AC D5J710;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:ACZ55944.1};
DE SubName: Full=Nonribosomal peptide synthetase anabaenopeptin synthetase AptC {ECO:0000313|EMBL:AFW93814.1};
GN Name=aptC {ECO:0000313|EMBL:ACZ55944.1};
GN ORFNames=ANA_C11026 {ECO:0000313|EMBL:AFW93814.1};
OS Anabaena sp. 90.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Anabaena.
OX NCBI_TaxID=46234 {ECO:0000313|EMBL:ACZ55944.1};
RN [1] {ECO:0000313|EMBL:ACZ55944.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=90 {ECO:0000313|EMBL:ACZ55944.1};
RX PubMed=20338518; DOI=10.1016/j.chembiol.2010.01.017;
RA Rouhiainen L., Jokela J., Fewer D.P., Urmann M., Sivonen K.;
RT "Two alternative starter modules for the non-ribosomal biosynthesis of
RT specific anabaenopeptin variants in Anabaena (Cyanobacteria).";
RL Chem. Biol. 17:265-273(2010).
RN [2] {ECO:0000313|EMBL:AFW93814.1, ECO:0000313|Proteomes:UP000010101}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=90 {ECO:0000313|EMBL:AFW93814.1};
RX PubMed=23148582; DOI=10.1186/1471-2164-13-613;
RA Wang H., Sivonen K., Rouhiainen L., Fewer D.P., Lyra C., Rantala-Ylinen A.,
RA Vestola J., Jokela J., Rantasarkka K., Li Z., Liu B.;
RT "Genome-derived insights into the biology of the hepatotoxic bloom-forming
RT cyanobacterium Anabaena sp. strain 90.";
RL BMC Genomics 13:613-613(2012).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; GU174493; ACZ55944.1; -; Genomic_DNA.
DR EMBL; CP003284; AFW93814.1; -; Genomic_DNA.
DR RefSeq; WP_015078978.1; NC_019427.1.
DR STRING; 46234.ANA_C11026; -.
DR KEGG; anb:ANA_C11026; -.
DR PATRIC; fig|46234.3.peg.1137; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_0_8_3; -.
DR OrthoDB; 473401at2; -.
DR Proteomes; UP000010101; Chromosome chANA01.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000010101};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 998..1073
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2469..2544
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2565 AA; 290227 MW; 0A203EFD892690EF CRC64;
MSDLLKRLEN LSPEKRELVL QKLKKQQQSP QLTPVSRDQF LPLSFAQQRL WFIDQLEGEN
CVYNVPFFWQ ISGLLNINAL EQAITAIVHR HEVLRTNFCV INESPIQVIH PHPQMKMQVL
DWRQLTAEDQ LSKAQHLATT ELQQSFDLSN APLLRVKLLQ LADQSHLLLL VIHHIVCDGW
SMGIFRQELF TLYTAFCKQE SSPLPELSLQ YADFAHWQRQ WLQGDVLQNQ LNYWQKQLAA
VPPLLELPTD RPRPSTQTYQ GSSQFLQLDQ DVTQQLKHLS QQSGTTLFMT LLTVFTLLLS
RYTGQEDIVV GSAIANRNRQ ETESLIGFFV NTLALRTNLQ GNPTFKELLE RVKQVTLDAY
DHQDLPFEKL VDELGLERSL SHHPLFQVVF GFQNETQEIL STNGLTLTPF TWENTTTLLD
LSLIFRETPQ GLTGEWEYTT DLFESETIQR MVGHFEVLLK QIIDHPNKPI NTLSLLTETE
IQQLQNWNQT QTSYPRDQTL VDLFEQQVIK NPDHIAVVFE SQQLTYQQLN KKANQLANYL
LKNHQIQPDK LIGIAVERSL EMIIGVLGIL KSGGAYVPID PNYPQERIQF MLADSEISVL
LTQSFLLEQL PLDNLENSVQ VICLDPENFA QETTDNPHSQ SQPDNLAYVI YTSGSTGQPK
GVMIEHRAIV NLALAWTTTF QVQNYSHLLQ FGSFSFDLSI GEIATALSAG ACLYLGNKDT
LLPGQSLVNF LTEHKITHGF LSPSALSVLP KASFPDLQCL TVGGEACPAE LVSQWGREQH
LYNCYGPTES TVTAAIYLCQ PNGEKPAIGK PIPNANIYIL DANNQLLPPG IPGELCISGV
GLARGYLNRP EITAEKFMEI DLFGKTERIY KTGDLAKWNA KGNLEYLGRI DEQVKLRGFR
IELGEIESLL LQHPLVQEAV VILYEIDNNP RLVAYIMATE KSANVAEKVR EYLKNRLPNY
MIPSQIMVLD QFPLTANGKL DRRALPAPHT ATSSDLEIPV TPTEELLASL WQGLLKVKSV
GRSDNFFELG GHSLLATQLV TRIRDIFGVE VPVRKIFEQN ILSELAREID QASASVALPP
ISPQPENEPK TPSFAQSRLW FIAQLEAKGT SSTYNMPVAF QLDGNLNLEA MRQSLTYLLE
RHSSLRSYFP TLEGEPQVVV KNVEDIEVLE IADLQALPPQ TQGETVQHLS DLHAQKSFDL
NTGPVFKAKL LQLSEQKNVL LINMHHIISD GWSMGVFKRE WEQAYTAYAA GSVPNLSPLA
IQYSDFAAWQ RSWLQGETLL TQENYWQQQL GDAPRLLELP TDYLRPAQQS YQGEREEFSL
SKELTQKLKA ISQQQGVSLF MTLLTAFNIL LSRYSRQEDL CVGSAIANRT HSYTEGLIGF
FVNTLVLRSK IKSEQSFSEL LQQTRQTCLD AYAHQDIPFE YLVEKLQPER SLSHNPLFQV
MMVLQNAVGA GAKVHLPGLE IQYLEQSFPF AKFDILLDLS ERDEQLHCMW EYATDLFAAS
TIRRMAAHFE VLLTAIVQNS QQPIYQLPII TPAEIQQLQV WNQTETDYPQ NHTLVSLFEN
QAAKTPDQIA VVSVDQSLSY QELNQKANRL ANYLLQLKSQ QQLSDPPLMA ICMERSLEML
IGIFAILKAG GTYLPIDPSY PQERIHLMLE DSHAAVLLTT KSLPQQLPLE KLKSTCQLVF
LDQPTWSDSP TENPQKFIRF DDLAYVIYTS GSTGKPKGVA IAHASAVAFV NWAHSVFSTE
QLAGVLASTS ICFDLSIFEI FVPLTQGGSV ILVENALYIE QAHQSSIPIT LINTVPSAAA
ELLNMNVIPS SVQVINLAGE PLRNNLVQAL YQNTSVQEVY NLYGPSEDTT YSTFTKVAKN
AQHEPTIGKA IANTRIYILD HANQPLPPGV PGELCIGGAG LAQGYLHRPD LTAEKFITLE
LFGKTERIYK TGDLARWLPD GNLQYLGRID HQVKLRGFRI ELGEIEASLL KHPKIQEAVV
LVREDSECYQ RLVTYVVPTT ESDYTSQSEQ VELWEQVFND SYTQQTTPTD DPTLNLAGWK
DSYTGEPILR SAMQEWRDTT VDQILELAPK RVWEIGCGTG MLLFKVASHC QHYLGTDFAS
SGLQYIEQHL KQQSLQNKVT LKQSAANQFD GIESNVYDLV IINSVIQYFP SLDYLLLVIA
GAIKTVSHQG KILIGDVRNL HLLSAFHTTT EFYRAPDDLS IQDLRQKIQN RIRTEEELLI
DPDFFIALKQ RFSRISHVQI ELKRGYSHTE MSRFRYDVIL HLDQVDIPLT QPQCLDWQEQ
QLNLATIERI LTTEQPDLLG IKSIPNARLT SEMALLAQIP QLDGTVTDLK AAIAQVKSGI
EPEAFRNLAR DLPYKAFIQY SSTGFSDYDV VFQRHIFEED KIPRFATKGN WRLKPWQNYA
NQPLQYRTNQ IDPALLAEWR DFLEKTLPDY MIPSHFVVLD KLPLTHNGKV DRKALPAPDP
KVAVTDIELP VTETEKLLAQ LWAKLLKYEV IGRQDNFFNL GGHSLLATQL CYRIRDTFKV
ELPLRQVFES PTIIDLANYI DSCIWVNSTT TDIQPLNSDE EEIEL
//