ID D5LPR1_CHICK Unreviewed; 490 AA.
AC D5LPR1; A0A1D6UPS2; F1NSE1;
DT 15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT 15-JUN-2010, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=Fascin {ECO:0000256|PIRNR:PIRNR005682};
GN Name=FSCN1 {ECO:0000313|EMBL:ADF45507.1,
GN ECO:0000313|Ensembl:ENSGALP00010030664.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:ADF45507.1};
RN [1] {ECO:0000313|EMBL:ADF45507.1}
RP NUCLEOTIDE SEQUENCE.
RA Saylor K.W., Gillespie P.G.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADF45507.1}
RP NUCLEOTIDE SEQUENCE.
RA Shin J.-B.;
RT "The R109H variant of fascin-2, a developmentally regulated actin
RT crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of
RT DBA/2J mice.";
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSGALP00010030664.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010030664.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR005682}.
CC -!- SIMILARITY: Belongs to the fascin family.
CC {ECO:0000256|ARBA:ARBA00007415, ECO:0000256|PIRNR:PIRNR005682}.
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DR EMBL; GU952796; ADF45507.1; -; mRNA.
DR RefSeq; NP_001171603.1; NM_001178132.1.
DR STRING; 9031.ENSGALP00000033359; -.
DR PaxDb; 9031-ENSGALP00000033359; -.
DR Ensembl; ENSGALT00010051473.1; ENSGALP00010030664.1; ENSGALG00010021237.1.
DR GeneID; 416485; -.
DR KEGG; gga:416485; -.
DR CTD; 6624; -.
DR VEuPathDB; HostDB:geneid_416485; -.
DR GeneTree; ENSGT00950000183157; -.
DR HOGENOM; CLU_030960_2_0_1; -.
DR OMA; NIFSMTR; -.
DR OrthoDB; 5484756at2759; -.
DR Proteomes; UP000000539; Chromosome 14.
DR Bgee; ENSGALG00000021128; Expressed in brain and 12 other cell types or tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0031253; C:cell projection membrane; IBA:GO_Central.
DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0030175; C:filopodium; IBA:GO_Central.
DR GO; GO:0030426; C:growth cone; IBA:GO_Central.
DR GO; GO:0030027; C:lamellipodium; IBA:GO_Central.
DR GO; GO:0044393; C:microspike; IEA:Ensembl.
DR GO; GO:0005902; C:microvillus; IBA:GO_Central.
DR GO; GO:0002102; C:podosome; IEA:Ensembl.
DR GO; GO:0001726; C:ruffle; IBA:GO_Central.
DR GO; GO:0001725; C:stress fiber; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:InterPro.
DR GO; GO:0051017; P:actin filament bundle assembly; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0007043; P:cell-cell junction assembly; IEA:Ensembl.
DR GO; GO:0035089; P:establishment of apical/basal cell polarity; IEA:Ensembl.
DR GO; GO:0007163; P:establishment or maintenance of cell polarity; IBA:GO_Central.
DR GO; GO:0030035; P:microspike assembly; IEA:Ensembl.
DR GO; GO:0030046; P:parallel actin filament bundle assembly; IEA:Ensembl.
DR GO; GO:0090091; P:positive regulation of extracellular matrix disassembly; IEA:Ensembl.
DR GO; GO:0051491; P:positive regulation of filopodium assembly; IEA:Ensembl.
DR GO; GO:0010592; P:positive regulation of lamellipodium assembly; IEA:Ensembl.
DR GO; GO:0071803; P:positive regulation of podosome assembly; IEA:Ensembl.
DR GO; GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0032534; P:regulation of microvillus assembly; IEA:Ensembl.
DR CDD; cd00257; Fascin; 4.
DR Gene3D; 2.80.10.50; -; 4.
DR InterPro; IPR008999; Actin-crosslinking.
DR InterPro; IPR010431; Fascin.
DR InterPro; IPR022768; Fascin-domain.
DR InterPro; IPR024703; Fascin_metazoans.
DR PANTHER; PTHR10551; FASCIN; 1.
DR PANTHER; PTHR10551:SF23; FASCIN; 1.
DR Pfam; PF06268; Fascin; 4.
DR PIRSF; PIRSF005682; Fascin; 1.
DR SUPFAM; SSF50405; Actin-crosslinking proteins; 4.
PE 1: Evidence at protein level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR005682};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR005682};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR005682};
KW Proteomics identification {ECO:0007829|PeptideAtlas:D5LPR1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539}.
FT DOMAIN 21..132
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 140..253
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 266..374
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 389..490
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
SQ SEQUENCE 490 AA; 54172 MW; BC528B4BA4661D9A CRC64;
MTANGTAEPV QIQFGLINCG NKYLTAEAFG FKVNASAASM KKKQIWTLEQ DGEDSSAVLL
KSHLGRYLAA DKDGRVSCDS EEPGPDCRFL VVAHGDGRWS LQSEPHRRFF GGTEDRLSCF
APSVSPAEKW SVHLAMHPQA NLYSLARKRY AHLGPRRDEL AVDRDVPWGV DALITLLFVE
QRYSLQSCDH RLLRADGRLV PSAEPGTAFT LEFRCGKVAF RDGEGRYLAP SGPSGTLKAG
KSSKVGKDEL FALEQSCPQV VLRAGNDRNV STRQGMDLSA NQDEEGDQET YQLEINKDTK
KCAFRTYTGK YWTLTSNGGI QSTASTKNAS CYFDIEWCDK RITLRAANGK YVTAKKNGQL
AASMETAGET EHFVMKLINR PIIVLRGEHG FIGCRKVTGT LDSNRSSYDV FQLEFNDGAY
NIKDTTGKYW MVGSESSVTS SSDTPVDFFF EFCDYNKVAI KINGKYLKGD HAGVLKASAD
AIDASTLWEY
//
