ID D5P4C9_9MYCO Unreviewed; 757 AA.
AC D5P4C9;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Diguanylate cyclase (GGDEF) domain protein {ECO:0000313|EMBL:EFG79126.1};
GN ORFNames=HMPREF0591_1023 {ECO:0000313|EMBL:EFG79126.1};
OS Mycobacterium parascrofulaceum ATCC BAA-614.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium simiae complex.
OX NCBI_TaxID=525368 {ECO:0000313|EMBL:EFG79126.1, ECO:0000313|Proteomes:UP000003653};
RN [1] {ECO:0000313|EMBL:EFG79126.1, ECO:0000313|Proteomes:UP000003653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-614 {ECO:0000313|EMBL:EFG79126.1,
RC ECO:0000313|Proteomes:UP000003653};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFG79126.1}.
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DR EMBL; ADNV01000083; EFG79126.1; -; Genomic_DNA.
DR AlphaFoldDB; D5P4C9; -.
DR eggNOG; COG5001; Bacteria.
DR HOGENOM; CLU_000445_129_3_11; -.
DR Proteomes; UP000003653; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR PANTHER; PTHR33121:SF71; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 348..482
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 500..753
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 757 AA; 80546 MW; A58BC291CD0E9C6B CRC64;
MIVLATVALL VFAAMLVSSH GAPGRAAVAP VGSVIAGVFA TACSVRAARR SRGRQRLAWT
AMSAGLVGWT TGEAVWCHVV LGGGLPVASM SATNLGYLIL PFCALAGAIV IPSRDDSRFG
IGLLLDGILV AASLLVVFVV LPLGRSAHIA QALSVPRILV ATAAGVYVGL FALAFIVVMK
AEAGRKLSPS LMMLGWAVIA AAGVVNVFNN HAARAPDDLV ILGGAGGMYF FALSGLTSRP
GPEPDLGFSQ PSSRASLWLP YLPVLLAIVV GAVHFWPADR GEAFIFAVCV VLFLTTLARH
ILLLERKQRL LVAVSDATLR DPLTGLANQR LFDDRLAHAL RLHVHHSVPV SVLTVGVDDF
RLVNDTLGYD VGDKLLRGVG ERIQANVDES HTVARMGGDE FAILVEDRPG VAIHLANGLA
RSFEEPVDID DHRLDVRVSI GVASADSAIV TAPSPGNLIK QADAARFYAH LAGSTNVQTY
TPEMVVQLGE APAFDSAMAR LQLLGELRRA IDSRSLTLLY QPKFSMWTGS VRGAEALVRW
QHPRFGVLEP AQFLPLVREH GLMDALTDLV LSQAIADAAA WQDADAPIPV AVNLAAPSLD
QDALPDRIMS VLNRYGMSPS SLTIEITEDL VVADLAKART VLNRLRDNGI QVAIDDFGSG
YATLTYLREL PADEIKLGRE FIAPILHDDR AATIARSVIE LASTFGIATV AEGVEDRATA
QRLKEYGCDA VQGNFFCRPL PASKIPRVPA NSVLATQ
//
