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Database: UniProt
Entry: D5RJW5_9PROT
LinkDB: D5RJW5_9PROT
Original site: D5RJW5_9PROT 
ID   D5RJW5_9PROT            Unreviewed;       259 AA.
AC   D5RJW5;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   26-FEB-2020, entry version 32.
DE   SubName: Full=AP endonuclease, family 2 {ECO:0000313|EMBL:EFH12404.1};
DE            EC=5.3.1.22 {ECO:0000313|EMBL:EFH12404.1};
GN   Name=hyi2 {ECO:0000313|EMBL:EFH12404.1};
GN   ORFNames=HMPREF0731_1375 {ECO:0000313|EMBL:EFH12404.1};
OS   Roseomonas cervicalis ATCC 49957.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Acetobacteraceae; Roseomonas.
OX   NCBI_TaxID=525371 {ECO:0000313|EMBL:EFH12404.1, ECO:0000313|Proteomes:UP000005324};
RN   [1] {ECO:0000313|EMBL:EFH12404.1, ECO:0000313|Proteomes:UP000005324}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49957 {ECO:0000313|EMBL:EFH12404.1,
RC   ECO:0000313|Proteomes:UP000005324};
RA   Qin X., Bachman B., Battles P., Bell A., Bess C., Bickham C., Chaboub L.,
RA   Chen D., Coyle M., Deiros D.R., Dinh H., Forbes L., Fowler G.,
RA   Francisco L., Fu Q., Gubbala S., Hale W., Han Y., Hemphill L.,
RA   Highlander S.K., Hirani K., Hogues M., Jackson L., Jakkamsetti A.,
RA   Javaid M., Jiang H., Korchina V., Kovar C., Lara F., Lee S., Mata R.,
RA   Mathew T., Moen C., Morales K., Munidasa M., Nazareth L., Ngo R.,
RA   Nguyen L., Okwuonu G., Ongeri F., Patil S., Petrosino J., Pham C., Pham P.,
RA   Pu L.-L., Puazo M., Raj R., Reid J., Rouhana J., Saada N., Shang Y.,
RA   Simmons D., Thornton R., Warren J., Weissenberger G., Zhang J., Zhang L.,
RA   Zhou C., Zhu D., Muzny D., Worley K., Gibbs R.;
RL   Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the hyi family. {ECO:0000256|PIRNR:PIRNR006241}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFH12404.1}.
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DR   EMBL; ADVL01000229; EFH12404.1; -; Genomic_DNA.
DR   RefSeq; WP_007005224.1; NZ_GG770781.1.
DR   EnsemblBacteria; EFH12404; EFH12404; HMPREF0731_1375.
DR   HOGENOM; CLU_050006_1_2_5; -.
DR   OrthoDB; 1007505at2; -.
DR   BioCyc; GCF_000164635-HMP:HMPREF0731_RS16050-MONOMER; -.
DR   Proteomes; UP000005324; Unassembled WGS sequence.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0008903; F:hydroxypyruvate isomerase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR026040; HyI-like.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR   Pfam; PF01261; AP_endonuc_2; 1.
DR   PIRSF; PIRSF006241; HyI; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
PE   3: Inferred from homology;
KW   Endonuclease {ECO:0000313|EMBL:EFH12404.1};
KW   Hydrolase {ECO:0000313|EMBL:EFH12404.1};
KW   Isomerase {ECO:0000256|PIRNR:PIRNR006241, ECO:0000313|EMBL:EFH12404.1};
KW   Nuclease {ECO:0000313|EMBL:EFH12404.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005324}.
FT   DOMAIN          21..218
FT                   /note="AP_endonuc_2"
FT                   /evidence="ECO:0000259|Pfam:PF01261"
FT   ACT_SITE        142
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR006241-50"
FT   ACT_SITE        239
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR006241-50"
SQ   SEQUENCE   259 AA;  28528 MW;  F08D487488D11D94 CRC64;
     MPRFAANLSM MFTDVPFLDR FARAAAAGFE AVEFLFPYDH PPEVVAEKLN SAGLTQALFN
     MPPGDWAAGE RGMAAIPGRE QEFRDNVATA ITYARALGCK TLHAMSGLTE GLDRAACEAT
     FVENFRYAAD ALAPHGITLL VEPINSRNMP GYFIAHQLDA IALIERVARP NVALQLDLYH
     AQIMDGDLTK LIEKLAGRFA HVQIASVPER HEPDEGELNY PHLYAVLDRV GYKGWIGCEY
     NPRAATEAGL GWFASYKAR
//
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