ID D5RL28_9PROT Unreviewed; 541 AA.
AC D5RL28;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit {ECO:0000313|EMBL:EFH11993.1};
DE EC=2.1.1.132 {ECO:0000313|EMBL:EFH11993.1};
GN Name=cbiE {ECO:0000313|EMBL:EFH11993.1};
GN ORFNames=HMPREF0731_1789 {ECO:0000313|EMBL:EFH11993.1};
OS Pseudoroseomonas cervicalis ATCC 49957.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Acetobacteraceae; Pseudoroseomonas.
OX NCBI_TaxID=525371 {ECO:0000313|EMBL:EFH11993.1, ECO:0000313|Proteomes:UP000005324};
RN [1] {ECO:0000313|EMBL:EFH11993.1, ECO:0000313|Proteomes:UP000005324}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49957 {ECO:0000313|EMBL:EFH11993.1,
RC ECO:0000313|Proteomes:UP000005324};
RA Qin X., Bachman B., Battles P., Bell A., Bess C., Bickham C., Chaboub L.,
RA Chen D., Coyle M., Deiros D.R., Dinh H., Forbes L., Fowler G.,
RA Francisco L., Fu Q., Gubbala S., Hale W., Han Y., Hemphill L.,
RA Highlander S.K., Hirani K., Hogues M., Jackson L., Jakkamsetti A.,
RA Javaid M., Jiang H., Korchina V., Kovar C., Lara F., Lee S., Mata R.,
RA Mathew T., Moen C., Morales K., Munidasa M., Nazareth L., Ngo R.,
RA Nguyen L., Okwuonu G., Ongeri F., Patil S., Petrosino J., Pham C., Pham P.,
RA Pu L.-L., Puazo M., Raj R., Reid J., Rouhana J., Saada N., Shang Y.,
RA Simmons D., Thornton R., Warren J., Weissenberger G., Zhang J., Zhang L.,
RA Zhou C., Zhu D., Muzny D., Worley K., Gibbs R.;
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFH11993.1}.
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DR EMBL; ADVL01000292; EFH11993.1; -; Genomic_DNA.
DR AlphaFoldDB; D5RL28; -.
DR HOGENOM; CLU_031955_0_0_5; -.
DR OrthoDB; 9787825at2; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000005324; Unassembled WGS sequence.
DR GO; GO:0046025; F:precorrin-6Y C5,15-methyltransferase (decarboxylating) activity; IEA:UniProtKB-EC.
DR GO; GO:0008276; F:protein methyltransferase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd11644; Precorrin-6Y-MT; 1.
DR Gene3D; 3.30.420.180; CobE/GbiG C-terminal domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR012818; CbiE.
DR InterPro; IPR014008; Cbl_synth_MTase_CbiT.
DR InterPro; IPR002750; CobE/GbiG_C.
DR InterPro; IPR036518; CobE/GbiG_C_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR02467; CbiE; 1.
DR NCBIfam; TIGR02469; CbiT; 1.
DR PANTHER; PTHR43182; COBALT-PRECORRIN-6B C(15)-METHYLTRANSFERASE (DECARBOXYLATING); 1.
DR PANTHER; PTHR43182:SF1; COBALT-PRECORRIN-7 C(5)-METHYLTRANSFERASE; 1.
DR Pfam; PF01890; CbiG_C; 1.
DR Pfam; PF01135; PCMT; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF159664; CobE/GbiG C-terminal domain-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 4: Predicted;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EFH11993.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005324};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EFH11993.1}.
FT DOMAIN 6..186
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 423..535
FT /note="CobE/GbiG C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01890"
SQ SEQUENCE 541 AA; 56168 MW; ACD1751D589BB1FD CRC64;
MNTPWLTILG IGEDGVEGLS PAAATLLAGA EAVFGAARQI ALAAPLIRGE RHPWPSPMLE
GIPALLARRG RRTVVLASGD PFCFGIGATL ARHLEAGEFL TLPAPSAFSL AASRLGWALQ
DCATISFCGR PVERLLPLLQ PGARILALSA DASTPAEVAA LLERHGFGPT RLHLLEALGG
PRERVRMAEA RGFALRPDPL NLLALEVVPG LGARILPLSA GLDESLFEHD GQITKREVRA
VTLAALAPRQ GELLWDVGCG SGSVAIEWLL RHPANRAIGL EPRADRLTRA ARNAAQFGVP
GLELVEAAAP QGFEGLPRPD AIFLGGGASR PGVLEAAWAA LRPGGRLVAN AVTVETEMVL
LAAFGRWGGE LTRIGVERLD RVGAFHGYRP AMTVVQYAVC KPEAGSGGTL SPQRGPGAEP
LATAGLGLRP AASGPDLVAL IRRAEALSGH RVVRLAAPAF REGAEALSFA ADTLGLPVVF
IDRDALLSVQ GRCPSRSEAS LRATGIASVA EGCALAQGGR LVLARIDGSG VSCALSTESE
T
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