ID D5SN32_PLAL2 Unreviewed; 781 AA.
AC D5SN32;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN OrderedLocusNames=Plim_0106 {ECO:0000313|EMBL:ADG65959.1};
OS Planctopirus limnophila (strain ATCC 43296 / DSM 3776 / IFAM 1008 / Mu 290)
OS (Planctomyces limnophilus).
OC Bacteria; Planctomycetota; Planctomycetia; Planctomycetales;
OC Planctomycetaceae; Planctopirus.
OX NCBI_TaxID=521674 {ECO:0000313|EMBL:ADG65959.1, ECO:0000313|Proteomes:UP000002220};
RN [1] {ECO:0000313|EMBL:ADG65959.1, ECO:0000313|Proteomes:UP000002220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43296 / DSM 3776 / IFAM 1008 / 290
RC {ECO:0000313|Proteomes:UP000002220};
RX PubMed=21304691; DOI=10.4056/sigs.1052813;
RA Labutti K., Sikorski J., Schneider S., Nolan M., Lucas S.,
RA Glavina Del Rio T., Tice H., Cheng J.F., Goodwin L., Pitluck S.,
RA Liolios K., Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A.,
RA Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Tindall B.J., Rohde M., Goker M., Woyke T., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P., Lapidus A.;
RT "Complete genome sequence of Planctomyces limnophilus type strain (Mu
RT 290).";
RL Stand. Genomic Sci. 3:47-56(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001744; ADG65959.1; -; Genomic_DNA.
DR RefSeq; WP_013108390.1; NC_014148.1.
DR AlphaFoldDB; D5SN32; -.
DR STRING; 521674.Plim_0106; -.
DR KEGG; plm:Plim_0106; -.
DR eggNOG; COG0188; Bacteria.
DR HOGENOM; CLU_002977_4_1_0; -.
DR Proteomes; UP000002220; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 3.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:ADG65959.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002220};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 12..475
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
SQ SEQUENCE 781 AA; 87854 MW; 3D737238E1F0345A CRC64;
MTENQEDRIQ FREISSETRR RYLNYAMSVI QSRALPDVRD GLKPVQRRIL YVMYEELRLM
ADAKTRKCAK ISGDTTGNYH PHGNQSVYDT LVRLAQDFTL RYPLVDGQGN FGSIMGLPAA
AERYTEARLT GIAEQLMNEL RFDTVEMRPN YDGTRKEPVV LPTRFPNLLV NGTAGIAVGM
ATNMPPHNLK EVLEACIHLI TNPEASTKEL LKFIKGPDFP LGGRMITDRK AMLPIYEEGR
GAFKVRAEWR MDKEKRAEVE DRVVIYSVPY GVETGPLLAE IGNVIASRKL PQLINAADET
DDKHGLRVVL ELKKGSDPES VMAFLYKKTP LEQNFNYNST VLIPDDQGLL TPARLPLHRL
LGEFLKFRLK VVKKRFQFQL DQLQARIHIL RGLEIIFNGI DKAIKIIRNS NGKRDACDKL
MAAFPLDEPQ TMAILEMQLY RISQLEIDTV LAELNTKQKE ADRITRILAK DDRIWNVIEG
ELRELSEQFG DKRRTTLGSS DEVTEFDESH YIVRENTNVV LSKDGWIKRV GRLQSVESTR
VREGDQVLDV LPGSTVDHVI FFASDGIAYT MPISQVPVSS GYGEPLTKHY KFKDGVQVIA
AVTTDPRFTA VAEETAEGAE PAPPHLFVTT AQGQVMRVPL QPFRTASTRS GRKFCKLQEG
DVVAKVELIV DQTSVFLVTR EARLIHFSLE EIPVLSGAGK GVRGIRLEEK EKDLVLGAAL
MSRPSDVLRL KLANEKELTC GQMKYALTTR GGKGVKVSHR SQVGEIVRPE IALVDWNSIE
G
//
