ID D5UM28_TSUPD Unreviewed; 612 AA.
AC D5UM28;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Penicillin-binding protein transpeptidase {ECO:0000313|EMBL:ADG78308.1};
GN OrderedLocusNames=Tpau_1690 {ECO:0000313|EMBL:ADG78308.1};
OS Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / CCUG 35730 / CIP
OS 100753 / JCM 10117 / KCTC 9821 / NBRC 16120 / NCIMB 702349 / NCTC 13040)
OS (Corynebacterium paurometabolum).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Tsukamurellaceae;
OC Tsukamurella.
OX NCBI_TaxID=521096 {ECO:0000313|EMBL:ADG78308.1, ECO:0000313|Proteomes:UP000001213};
RN [1] {ECO:0000313|Proteomes:UP000001213}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8368 / DSM 20162 / CCUG 35730 / CIP 100753 / JCM 10117 /
RC KCTC 9821 / NBRC 16120 / NCIMB 702349 / NCTC 13040
RC {ECO:0000313|Proteomes:UP000001213};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA Mikhailova N., Munk A.C., Brettin T., Detter J.C., Tapia R., Han C.,
RA Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA Woyke T., Wu D., Jando M., Brambilla E., Klenk H.-P., Eisen J.A.;
RT "The complete chromosome of Tsukamurella paurometabola DSM 20162.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADG78308.1, ECO:0000313|Proteomes:UP000001213}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8368 / DSM 20162 / CCUG 35730 / CIP 100753 / JCM 10117 /
RC KCTC 9821 / NBRC 16120 / NCIMB 702349 / NCTC 13040
RC {ECO:0000313|Proteomes:UP000001213};
RX PubMed=21886861;
RA Munk A.C., Lapidus A., Lucas S., Nolan M., Tice H., Cheng J.F.,
RA Del Rio T.G., Goodwin L., Pitluck S., Liolios K., Huntemann M., Ivanova N.,
RA Mavromatis K., Mikhailova N., Pati A., Chen A., Palaniappan K., Tapia R.,
RA Han C., Land M., Hauser L., Chang Y.J., Jeffries C.D., Brettin T.,
RA Yasawong M., Brambilla E.M., Rohde M., Sikorski J., Goker M., Detter J.C.,
RA Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Tsukamurella paurometabola type strain (no.
RT 33).";
RL Stand. Genomic Sci. 4:342-351(2011).
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; CP001966; ADG78308.1; -; Genomic_DNA.
DR AlphaFoldDB; D5UM28; -.
DR STRING; 521096.Tpau_1690; -.
DR KEGG; tpr:Tpau_1690; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_025328_0_0_11; -.
DR Proteomes; UP000001213; Chromosome.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR007887; MecA_N.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF24; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE PBPA; 1.
DR Pfam; PF05223; MecA_N; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001213};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..612
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5038352780"
FT DOMAIN 31..143
FT /note="NTF2-like N-terminal transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF05223"
FT DOMAIN 332..587
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 612 AA; 62930 MW; 311355AC0B68F99D CRC64;
MNKLGTRVVV ILALVAMVVT GGCAPANSNG PGPVAVRFGA ALAEKNLDGA AALTSSPAAA
KAMLQGTFDG LQARGVTLKV GQVRTQGSTS AVDYEYVWDL PADRGRSNRT WTYQGTLTAV
QENGQWKVRW DPTVLHPRLG ANQTMVLKAL PAPKAPVNSA SGGSVLVPGV VTRIRLEAAK
VTAPTTVLDV AGQLTRALQP IVPGLDPVQL TEQATSFQGP YVVATVNQDD LRKLAGDVTA
LPGVSLVEQA DLVPTDRTFA PALMSSIKKN VEGDLGGKDG WEVVVQADTG AQVVTLTSTP
AQTAAAATVS ISPIAQAAAQ AAVDTRRDRQ AMMVVIQPST GDVLAVAQNP EADKQGSLAT
SGLYPPGSTG KIVTATAAIS TGTATPDTIV PCPGTLTIGE REMPNYNRFA LGDVTMQRAF
ARSCNTSFAY LGSKMAFDAL PTAASELGVG PDYDIPGLPV ASGGYPTPKA MVNQVEDSFG
QGEVLVSPFS MALVAAAVAK GGAVTPRLLG GKATKVDGDR PPLDPRAVDG VRAMMREVVA
SGTAELIRGS GDILGKTGEA EVEGGSHAWF VGYRGDLAFA TMVVLGGSSD NAVGVTKEFF
DRFDAPVGAV PN
//
