ID D5URF4_TSUPD Unreviewed; 997 AA.
AC D5URF4;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Large membrane protein {ECO:0000313|EMBL:ADG77007.1};
GN OrderedLocusNames=Tpau_0364 {ECO:0000313|EMBL:ADG77007.1};
OS Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / CCUG 35730 / CIP
OS 100753 / JCM 10117 / KCTC 9821 / NBRC 16120 / NCIMB 702349 / NCTC 13040)
OS (Corynebacterium paurometabolum).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Tsukamurellaceae;
OC Tsukamurella.
OX NCBI_TaxID=521096 {ECO:0000313|EMBL:ADG77007.1, ECO:0000313|Proteomes:UP000001213};
RN [1] {ECO:0000313|Proteomes:UP000001213}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8368 / DSM 20162 / CCUG 35730 / CIP 100753 / JCM 10117 /
RC KCTC 9821 / NBRC 16120 / NCIMB 702349 / NCTC 13040
RC {ECO:0000313|Proteomes:UP000001213};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA Mikhailova N., Munk A.C., Brettin T., Detter J.C., Tapia R., Han C.,
RA Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA Woyke T., Wu D., Jando M., Brambilla E., Klenk H.-P., Eisen J.A.;
RT "The complete chromosome of Tsukamurella paurometabola DSM 20162.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADG77007.1, ECO:0000313|Proteomes:UP000001213}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8368 / DSM 20162 / CCUG 35730 / CIP 100753 / JCM 10117 /
RC KCTC 9821 / NBRC 16120 / NCIMB 702349 / NCTC 13040
RC {ECO:0000313|Proteomes:UP000001213};
RX PubMed=21886861;
RA Munk A.C., Lapidus A., Lucas S., Nolan M., Tice H., Cheng J.F.,
RA Del Rio T.G., Goodwin L., Pitluck S., Liolios K., Huntemann M., Ivanova N.,
RA Mavromatis K., Mikhailova N., Pati A., Chen A., Palaniappan K., Tapia R.,
RA Han C., Land M., Hauser L., Chang Y.J., Jeffries C.D., Brettin T.,
RA Yasawong M., Brambilla E.M., Rohde M., Sikorski J., Goker M., Detter J.C.,
RA Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Tsukamurella paurometabola type strain (no.
RT 33).";
RL Stand. Genomic Sci. 4:342-351(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001966; ADG77007.1; -; Genomic_DNA.
DR RefSeq; WP_013125053.1; NC_014158.1.
DR AlphaFoldDB; D5URF4; -.
DR STRING; 521096.Tpau_0364; -.
DR KEGG; tpr:Tpau_0364; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_8_0_11; -.
DR Proteomes; UP000001213; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001213};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 629..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 656..679
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 715..733
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 230..359
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 798..997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..985
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 997 AA; 105389 MW; 467DC0D2F3EBF3C3 CRC64;
MFAAIGRFSY AFRYTIIAVL FVSIAATGVW GFLGLGSKTK MNGLYDEKSD SVAASKLTDE
ANGRFAQSDI LVLVKAADGK KVTDAEVKDS VESARTKILD QFAKGPDAKL YGADAENTSM
RPASYTTLPA ADNPFVRNEA NGESWGFFTL PLKSNDDTQR GLDWADIREP IRDILKTQAD
GKFEARFAGL VPVTSEVTEG VQRDQKKAEL IALPLVAIVL FFVYGGIVAA VLPMIIGVMT
IGASMAIASV LAQFMEVNLF VGPIISLIGL GIAHDYGLFM VSRFREELDE GYDTPTAVRR
TVMTAGRTIV MSSLLIVGAL ACLYISPLGL LTSMATGALL GVFIAALLSL VLLPAMLAVL
GPRVFALSFH WFLTIFDKWK LPLIGGIIHW AAEKTGKPKT KANIENGMWG KVTDAVMRKP
IAYTVGVVTL LLAITIPVIG LQFGGISQTY LPPTNETRQA QDKFFETFPA YTGQSIQIVF
TNADDAQIKQ VLDEANKIPG FVHTDPADRN SSRFSPPTAA VATAKSDGSP LQIRGEGPEV
KVRTSNGNLQ DPNDTKAVSQ AVEQIRGITM DGADASKGVG FMVGGMPTLQ NDSIDSMLGK
LPLLMGLLVV VTTLMMFLAF GSLVLPIKAV LMSILSLGST LGFLTWMFVD GHGGSIFNFS
GGPLMAPVLV LVIAVVFGLS TDYEVFVISR MIEERAAGAT TVQSIRAGTA NTGRIITAAA
ILLACVAAAF ATSDLVMMKY VSFGLMFALL IDATVVRMVL VPAVMKLLGD DCWWAPEWMR
KIQHAIGLGE TALPAETRDG RPLASVRPPS AVPGRAAPQL VGAGAPVVPG SLGSAEQRPI
PDSAADPTAP SNNERPSGQI RMGNRRPGPP PAGQPPRPSA PMQRPPQDPR SYQPPVPGQR
RPGPPPQGPG GPRGPQGPYG PPGQGGGPRP SGPMPRQQRP GGPAGPGGPG GPRPPYPPRP
QGPGGPGGPG GRGPGQRPFP GPSGDGPRPH QQRDRDE
//
