ID D5V300_ARCNC Unreviewed; 713 AA.
AC D5V300;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=(P)ppGpp synthetase I, SpoT/RelA {ECO:0000313|EMBL:ADG92582.1};
DE EC=2.7.6.5 {ECO:0000313|EMBL:ADG92582.1};
GN OrderedLocusNames=Arnit_0918 {ECO:0000313|EMBL:ADG92582.1};
OS Arcobacter nitrofigilis (strain ATCC 33309 / DSM 7299 / CCUG 15893 / LMG
OS 7604 / NCTC 12251 / CI) (Campylobacter nitrofigilis).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Arcobacteraceae; Arcobacter.
OX NCBI_TaxID=572480 {ECO:0000313|EMBL:ADG92582.1, ECO:0000313|Proteomes:UP000000939};
RN [1] {ECO:0000313|EMBL:ADG92582.1, ECO:0000313|Proteomes:UP000000939}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33309 / DSM 7299 / CCUG 15893 / LMG 7604 / NCTC 12251 / CI
RC {ECO:0000313|Proteomes:UP000000939};
RX PubMed=21304714; DOI=10.4056/sigs.912121;
RA Pati A., Gronow S., Lapidus A., Copeland A., Glavina Del Rio T., Nolan M.,
RA Lucas S., Tice H., Cheng J.F., Han C., Chertkov O., Bruce D., Tapia R.,
RA Goodwin L., Pitluck S., Liolios K., Ivanova N., Mavromatis K., Chen A.,
RA Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D., Detter J.C.,
RA Rohde M., Goker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Klenk H.P., Kyrpides N.C.;
RT "Complete genome sequence of Arcobacter nitrofigilis type strain (CI).";
RL Stand. Genomic Sci. 2:300-308(2010).
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
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DR EMBL; CP001999; ADG92582.1; -; Genomic_DNA.
DR RefSeq; WP_013134727.1; NC_014166.1.
DR AlphaFoldDB; D5V300; -.
DR STRING; 572480.Arnit_0918; -.
DR KEGG; ant:Arnit_0918; -.
DR eggNOG; COG0317; Bacteria.
DR HOGENOM; CLU_012300_3_0_7; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000000939; Chromosome.
DR GO; GO:0008728; F:GTP diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000939};
KW Transferase {ECO:0000313|EMBL:ADG92582.1}.
FT DOMAIN 395..457
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
SQ SEQUENCE 713 AA; 83536 MW; EBCE9572AAFC7138 CRC64;
MDPYINKIQR INTIKSAFAE LSSQIEITPK LKEIVDFTIQ AHEGQFRKSG EPYAVHPLLV
ACITAHFSAE EPIVAAALLH DVVEDTQYPL EVVKKRWGED ISYIVDGLTK IDEIRESELV
SSDSDKKIVT SALTFRKLLV ASIDDPRVLV VKLCDRLHNM LTLSALPPKK QFRIAEETLV
VYVPIAHRLG ISTIKNELED LAFFYIYPDE YKKIDDFMKE NQQTIQIGFN EFISSTKMLL
EKNGYDESKV KIFSRVKHHY SIYMKIQRKG VTIDEILDLM AIRILVNKEI DCYKVLGHIH
LEYKPLISRF KDYVATPKEN GYQTIHSTVF FNSKIHEVQI RTFEMHKVAE YGIAAHWKYK
SGIKHSPNLN WLKSLEYTNE NVEEFYTEAK EDLYSEDMVI YSPRGDTFTL PRSATAYDYA
YMIHTDVGNK AVDCYINKVR KPLLTELKSS DIVSINTTDH NIPRCSWIHM VRTNRAKKQI
KLLCTQRDKE INEYSGRNIL NTIFEKYKTY IVADHKIENV YKIPLLLDYL KHTKKMIEKK
IQENMNFVER FKLIPKKLKE YKFENILIYS NYSINSVSFE HCCHPKIGDD IVAFKEGNKA
IIHHKMCDKA YKKIKAEKEM LFCKWVENEL YQYKMVVSLQ NTKGELAKLL TYMSQYEGYI
LSVSYGREQH SYIQYSDIEF EIDKKNRDEV RKIIEKKAKV IEFFSKKDAY NKN
//
