ID D5V7R6_ARCNC Unreviewed; 1180 AA.
AC D5V7R6;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN OrderedLocusNames=Arnit_3038 {ECO:0000313|EMBL:ADG94686.1};
OS Arcobacter nitrofigilis (strain ATCC 33309 / DSM 7299 / CCUG 15893 / LMG
OS 7604 / NCTC 12251 / CI) (Campylobacter nitrofigilis).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Arcobacteraceae; Arcobacter.
OX NCBI_TaxID=572480 {ECO:0000313|EMBL:ADG94686.1, ECO:0000313|Proteomes:UP000000939};
RN [1] {ECO:0000313|EMBL:ADG94686.1, ECO:0000313|Proteomes:UP000000939}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33309 / DSM 7299 / CCUG 15893 / LMG 7604 / NCTC 12251 / CI
RC {ECO:0000313|Proteomes:UP000000939};
RX PubMed=21304714; DOI=10.4056/sigs.912121;
RA Pati A., Gronow S., Lapidus A., Copeland A., Glavina Del Rio T., Nolan M.,
RA Lucas S., Tice H., Cheng J.F., Han C., Chertkov O., Bruce D., Tapia R.,
RA Goodwin L., Pitluck S., Liolios K., Ivanova N., Mavromatis K., Chen A.,
RA Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D., Detter J.C.,
RA Rohde M., Goker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Klenk H.P., Kyrpides N.C.;
RT "Complete genome sequence of Arcobacter nitrofigilis type strain (CI).";
RL Stand. Genomic Sci. 2:300-308(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; CP001999; ADG94686.1; -; Genomic_DNA.
DR RefSeq; WP_013136831.1; NC_014166.1.
DR AlphaFoldDB; D5V7R6; -.
DR STRING; 572480.Arnit_3038; -.
DR KEGG; ant:Arnit_3038; -.
DR eggNOG; COG0587; Bacteria.
DR HOGENOM; CLU_001600_0_0_7; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000000939; Chromosome.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000000939};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 8..75
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1180 AA; 134289 MW; 03F9A7EA5D9979A5 CRC64;
MSQIPEFTHL HLHTEYSLLD GANKIKDLAK KIKALGMKSV AMTDHGNMFG AIDFYKAMKA
EGIKPIIGME AYIHNSEELD DKSHRKRFHL CLYAKNQVGY KNLMFLTSQA YMHGFYYYPR
INKKILRENS EGLVCSAACL QGEVNWHLNT QSERNVKNGA KGYEEAKRIA LEYKEIFGDD
FYLEIMRHGI SDQHFIDDQI LRISKETGIK VVATNDTHYL KQKDAQAHEA FMCIAMNKLY
DDPNRLRHSV HEFYLKSSEQ ISKLYADIPE TIAATQEIVE KCNLEIKLGD PTPPNFKFTR
EKSQEEGLTL PEPELEYSLE NDKILFVHEC WKGLEKRLEI VPQERHQEYK DRLQVEIDII
NSMKFPGYML IVWDFVIAAK QMKIPVGPGR GSAAGSLVAF SLAITDIDPL PYGLLFERFL
NPERVSMPDI DMDFCQARRQ EILDYVIEKY GRANVAQIIT FGKLLAKGVI RDVARVLDMP
YSQADAMAKL IPDELGINLT SSYEKEPKIK ELCDSNPQAK RVWDFAIALE GLNRNAGTHA
AGVVISNEPL WNKTPLFKPS GMETLATQYN GKYVEDVDLI KFDFLGLKTL TVIEEANKLI
EQRHGKRVNF LTVDVNDKGV YDLIQTGNTI GLFQIESDGM QDLCKRLKPS NFEDIIAVLA
LYRPGPMESG MLDDFIDRKH GREEINYFYD EFDAPLRPIL ETTYGVIVYQ EQVMQIVQTI
GGFSLGGADL VRRAMGKKIK EEMDRLKGEF AIGGVKKGFV KEHCEELFDL IVKFAGYGFN
KSHSAAYALV TFYTSYLKKY YPSEFMAALL TLEKDNTDKV VKYVDEVKRL KLDLFPPDIN
KSDLVFAPKK IDGQEVVMFG MGAIKGAGDV AIKSILKERN ENGNFEDFAD FISRVDGSKV
NKRVFESLAK AGGFDTFGYS RRSILEQIET INETVGKAMA AKKMATGSLF GDSKELTKVE
VQLEKFEEYE LKELLELEKQ SLGFYVSGHP LDEYREQLDG INYTLSSELE DLGDGSEALF
IGKVETINER ISKKGNKFAI LNLMDLHGNI ELMLFEDRLK ELKEDFDLTE PIAFKVRISK
DDQFTRISLR KIETLKEAKK EKIKTKQKAI EEPPITVAVN FTDDDKIMYD LFEIIAHNQG
KRELKLLVKS KLADIELDTG FKVTSNIEGL IKSLDGVFIA
//
