ID D5X4M9_THIK1 Unreviewed; 387 AA.
AC D5X4M9;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 24-JAN-2024, entry version 65.
DE RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369};
GN OrderedLocusNames=Tint_2344 {ECO:0000313|EMBL:ADG31693.1};
OS Thiomonas intermedia (strain K12) (Thiobacillus intermedius).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales; Thiomonas.
OX NCBI_TaxID=75379 {ECO:0000313|EMBL:ADG31693.1};
RN [1] {ECO:0000313|EMBL:ADG31693.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 {ECO:0000313|EMBL:ADG31693.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Kyrpides N., Ovchinnikova G., Kerfeld C.A., Cannon G.C.,
RA Heinhorst S., Woyke T.;
RT "Complete sequence of Thiomonas intermedia K12.";
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000308};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC from oxaloacetate: step 1/2. {ECO:0000256|ARBA:ARBA00004751}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369,
CC ECO:0000256|RuleBase:RU003406}.
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DR EMBL; CP002021; ADG31693.1; -; Genomic_DNA.
DR AlphaFoldDB; D5X4M9; -.
DR STRING; 75379.Tint_2344; -.
DR KEGG; tin:Tint_2344; -.
DR eggNOG; COG0372; Bacteria.
DR HOGENOM; CLU_025068_2_1_4; -.
DR OMA; NEAVMHM; -.
DR BioCyc; TINT75379:TINT_RS11730-MONOMER; -.
DR UniPathway; UPA00223; UER00717.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR011278; 2-MeCitrate/Citrate_synth_II.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR019810; Citrate_synthase_AS.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR NCBIfam; TIGR01800; cit_synth_II; 1.
DR PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR11739:SF25; CITRATE SYNTHASE-RELATED PROTEIN DDB_G0287281; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
DR PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:ADG31693.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR001369}.
FT ACT_SITE 272
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT ACT_SITE 323
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ SEQUENCE 387 AA; 42457 MW; 7F422DC2F2CEFE06 CRC64;
MSDDAAPAGM TFKPKKSVAL SGVTAGNTAL CTVGRTGNDL HYRGYDILDL AEACEFEEIA
HLLVHGKLPN TAELAAYKTK LRRLRGLPAA VKAALEQLPP SAHPMDVLRT GVSVLGCVMP
EKDDHNVAGA RDIADKLMAC QGSMLLYWWH YAANGRRIEV ETDDDSIGGH FLHLLHGYKP
SALWERAMHT SLILYAEHEF NASTFTARVI AGTGSDLFSA IAGAIGALRG PKHGGANEAA
LDIQRRYASP DEAEADIRSR VANKEVVIGF GHPVYTIADP RNKVIKEVAR RLSADQKNMH
LFNVAERLET VMWDVKKMFP NLDWFSAVSY SLMGVPTAMF TPLFVISRTS GWSAHVVEQR
QDNKIIRPSA NYTGPENLQF VPLAQRP
//