ID D5X8E4_THEPJ Unreviewed; 211 AA.
AC D5X8E4;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Methionine synthase {ECO:0000313|EMBL:ADG80923.1};
DE EC=2.1.1.13 {ECO:0000313|EMBL:ADG80923.1};
GN OrderedLocusNames=TherJR_0027 {ECO:0000313|EMBL:ADG80923.1};
OS Thermincola potens (strain JR).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Thermincolaceae;
OC Thermincola.
OX NCBI_TaxID=635013 {ECO:0000313|EMBL:ADG80923.1, ECO:0000313|Proteomes:UP000002377};
RN [1] {ECO:0000313|EMBL:ADG80923.1, ECO:0000313|Proteomes:UP000002377}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JR {ECO:0000313|EMBL:ADG80923.1,
RC ECO:0000313|Proteomes:UP000002377};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Mikhailova N., Hazen T.C., Woyke T.;
RT "Complete sequence of Thermincola sp. JR.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002028; ADG80923.1; -; Genomic_DNA.
DR RefSeq; WP_013118952.1; NC_014152.1.
DR AlphaFoldDB; D5X8E4; -.
DR STRING; 635013.TherJR_0027; -.
DR KEGG; tjr:TherJR_0027; -.
DR eggNOG; COG5012; Bacteria.
DR HOGENOM; CLU_082102_2_0_9; -.
DR OrthoDB; 9783599at2; -.
DR Proteomes; UP000002377; Chromosome.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008705; F:methionine synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02070; corrinoid_protein_B12-BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 1.10.1240.10; Methionine synthase domain; 1.
DR InterPro; IPR003759; Cbl-bd_cap.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR036594; Meth_synthase_dom.
DR PANTHER; PTHR45833; METHIONINE SYNTHASE; 1.
DR PANTHER; PTHR45833:SF1; METHIONINE SYNTHASE; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF02607; B12-binding_2; 1.
DR SMART; SM01018; B12-binding_2; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF47644; Methionine synthase domain; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51337; B12_BINDING_NTER; 1.
PE 4: Predicted;
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000313|EMBL:ADG80923.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002377};
KW Transferase {ECO:0000313|EMBL:ADG80923.1}.
FT DOMAIN 1..88
FT /note="B12-binding N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51337"
FT DOMAIN 88..211
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
SQ SEQUENCE 211 AA; 22011 MW; C198EBE2FC7FAD3E CRC64;
MASFESVAQS VIAGQEAQVK EQVKALIDAG TNPLQIINEG LIAGMNVVGA RFKAGDMFVP
EVLMCAKAMA AGVEIVKPLI ADNDVQSKGK VVLGTVKGDL HDIGKNLVAM MMESGGLEVI
NLGIDVSPEK FADAVREHEP QIVAMSALLT TTMPAMKETI EYLEQAGLRD KVKVIVGGAP
ITKDFADSIG ADGFAPDAAS ATDLCKELIG A
//
