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Database: UniProt
Entry: D5XC44_THEPJ
LinkDB: D5XC44_THEPJ
Original site: D5XC44_THEPJ 
ID   D5XC44_THEPJ            Unreviewed;       518 AA.
AC   D5XC44;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   RecName: Full=Methylenetetrahydrofolate reductase {ECO:0000256|RuleBase:RU003862};
GN   OrderedLocusNames=TherJR_2661 {ECO:0000313|EMBL:ADG83496.1};
OS   Thermincola potens (strain JR).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Thermincolaceae;
OC   Thermincola.
OX   NCBI_TaxID=635013 {ECO:0000313|EMBL:ADG83496.1, ECO:0000313|Proteomes:UP000002377};
RN   [1] {ECO:0000313|EMBL:ADG83496.1, ECO:0000313|Proteomes:UP000002377}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JR {ECO:0000313|EMBL:ADG83496.1,
RC   ECO:0000313|Proteomes:UP000002377};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Hazen T.C., Woyke T.;
RT   "Complete sequence of Thermincola sp. JR.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-
CC         methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH;
CC         Xref=Rhea:RHEA:19821, ChEBI:CHEBI:15378, ChEBI:CHEBI:15636,
CC         ChEBI:CHEBI:18608, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.5.1.54;
CC         Evidence={ECO:0000256|ARBA:ARBA00034420};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:19823;
CC         Evidence={ECO:0000256|ARBA:ARBA00034420};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974,
CC         ECO:0000256|RuleBase:RU003862};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU003862}.
CC   -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC       {ECO:0000256|ARBA:ARBA00006743, ECO:0000256|RuleBase:RU003862}.
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DR   EMBL; CP002028; ADG83496.1; -; Genomic_DNA.
DR   RefSeq; WP_013121487.1; NC_014152.1.
DR   AlphaFoldDB; D5XC44; -.
DR   STRING; 635013.TherJR_2661; -.
DR   KEGG; tjr:TherJR_2661; -.
DR   eggNOG; COG0685; Bacteria.
DR   HOGENOM; CLU_536107_0_0_9; -.
DR   OrthoDB; 9803687at2; -.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000002377; Chromosome.
DR   GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   CDD; cd00537; MTHFR; 1.
DR   Gene3D; 3.20.20.220; -; 1.
DR   InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR   InterPro; IPR003171; Mehydrof_redctse-like.
DR   InterPro; IPR022026; MTHFR_C.
DR   PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR   PANTHER; PTHR45754:SF3; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR   Pfam; PF12225; DUF5981; 1.
DR   Pfam; PF02219; MTHFR; 1.
DR   SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU003862};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW   ECO:0000256|RuleBase:RU003862};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003862};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002377}.
FT   DOMAIN          395..487
FT                   /note="Methylene-tetrahydrofolate reductase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12225"
SQ   SEQUENCE   518 AA;  58259 MW;  3C5A55E5DE055DD5 CRC64;
     MQNRFKESLL DKNTMSVTWE LVPGRGAREK SQEEAIAAAE QAAKGGRIHA LTLTDNPGGN
     PAILADALAK EVLAKGIEPL VHFTCKDKNR NQIESQLYAL DRAGIRNLLV MTGDYTVTGY
     KGRPKPVFDL DPIHVLGLIG EMNKGLEYQG FKGTIKHQPS DFFAGAAASQ FKATEAEQML
     QYYKLKKKIE AGAQFIVTQL GYDARKFHEI IQFIRLNGWD IPVVGNIYIL PLGTAKVMNK
     NRIPGCVVTD KLVADLEREA QAPDKGKEAR LLRAAKMYAF MKGMGYNGVH IGGHGMKYED
     VEFIIDKGEE LSKNWMDFIH EFDYPQPNGF YYYEKDEKTG LNTTTPTNRK GRPLDAPVEF
     TYRLSKFMHN LMLEPGTPLW GPMTAVAKAV DGTSMEKKYH KFEHMIKVGL FDCKDCGDCA
     LMDVAYVCPM SQCPKNQRNG ACGGSFEGWC EVYPGKKKCA WVRAYARLKN SGKEEQLSKE
     VIPPANWDFH QTSSWLNFYL GRDHTAKKFG IEPYVKKK
//
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