ID D5XC44_THEPJ Unreviewed; 518 AA.
AC D5XC44;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Methylenetetrahydrofolate reductase {ECO:0000256|RuleBase:RU003862};
GN OrderedLocusNames=TherJR_2661 {ECO:0000313|EMBL:ADG83496.1};
OS Thermincola potens (strain JR).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Thermincolaceae;
OC Thermincola.
OX NCBI_TaxID=635013 {ECO:0000313|EMBL:ADG83496.1, ECO:0000313|Proteomes:UP000002377};
RN [1] {ECO:0000313|EMBL:ADG83496.1, ECO:0000313|Proteomes:UP000002377}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JR {ECO:0000313|EMBL:ADG83496.1,
RC ECO:0000313|Proteomes:UP000002377};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Mikhailova N., Hazen T.C., Woyke T.;
RT "Complete sequence of Thermincola sp. JR.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-
CC methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH;
CC Xref=Rhea:RHEA:19821, ChEBI:CHEBI:15378, ChEBI:CHEBI:15636,
CC ChEBI:CHEBI:18608, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.5.1.54;
CC Evidence={ECO:0000256|ARBA:ARBA00034420};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:19823;
CC Evidence={ECO:0000256|ARBA:ARBA00034420};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|RuleBase:RU003862};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU003862}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743, ECO:0000256|RuleBase:RU003862}.
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DR EMBL; CP002028; ADG83496.1; -; Genomic_DNA.
DR RefSeq; WP_013121487.1; NC_014152.1.
DR AlphaFoldDB; D5XC44; -.
DR STRING; 635013.TherJR_2661; -.
DR KEGG; tjr:TherJR_2661; -.
DR eggNOG; COG0685; Bacteria.
DR HOGENOM; CLU_536107_0_0_9; -.
DR OrthoDB; 9803687at2; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000002377; Chromosome.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00537; MTHFR; 1.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR InterPro; IPR022026; MTHFR_C.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF3; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF12225; DUF5981; 1.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU003862};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU003862};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003862};
KW Reference proteome {ECO:0000313|Proteomes:UP000002377}.
FT DOMAIN 395..487
FT /note="Methylene-tetrahydrofolate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12225"
SQ SEQUENCE 518 AA; 58259 MW; 3C5A55E5DE055DD5 CRC64;
MQNRFKESLL DKNTMSVTWE LVPGRGAREK SQEEAIAAAE QAAKGGRIHA LTLTDNPGGN
PAILADALAK EVLAKGIEPL VHFTCKDKNR NQIESQLYAL DRAGIRNLLV MTGDYTVTGY
KGRPKPVFDL DPIHVLGLIG EMNKGLEYQG FKGTIKHQPS DFFAGAAASQ FKATEAEQML
QYYKLKKKIE AGAQFIVTQL GYDARKFHEI IQFIRLNGWD IPVVGNIYIL PLGTAKVMNK
NRIPGCVVTD KLVADLEREA QAPDKGKEAR LLRAAKMYAF MKGMGYNGVH IGGHGMKYED
VEFIIDKGEE LSKNWMDFIH EFDYPQPNGF YYYEKDEKTG LNTTTPTNRK GRPLDAPVEF
TYRLSKFMHN LMLEPGTPLW GPMTAVAKAV DGTSMEKKYH KFEHMIKVGL FDCKDCGDCA
LMDVAYVCPM SQCPKNQRNG ACGGSFEGWC EVYPGKKKCA WVRAYARLKN SGKEEQLSKE
VIPPANWDFH QTSSWLNFYL GRDHTAKKFG IEPYVKKK
//