ID D5ZTZ7_STRV1 Unreviewed; 1869 AA.
AC D5ZTZ7;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:EFE64831.2};
DE Flags: Fragment;
GN ORFNames=SSFG_07870 {ECO:0000313|EMBL:EFE64831.2};
OS Streptomyces viridosporus (strain ATCC 14672 / DSM 40746 / JCM 4963 / KCTC
OS 9882 / NRRL B-12104 / FH 1290) (Streptomyces ghanaensis).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=566461 {ECO:0000313|EMBL:EFE64831.2, ECO:0000313|Proteomes:UP000003824};
RN [1] {ECO:0000313|Proteomes:UP000003824}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14672 / DSM 40746 / JCM 4963 / KCTC 9882 / NRRL B-12104 /
RC FH 1290 {ECO:0000313|Proteomes:UP000003824};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center;
RA Fischbach M., Ward D., Young S., Kodira C.D., Zeng Q., Koehrsen M.,
RA Godfrey P., Alvarado L., Berlin A.M., Borenstein D., Chen Z., Engels R.,
RA Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.I.,
RA Hepburn T.A., Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D.,
RA Pearson M., Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C.,
RA Sykes S.N., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland B.L.C., Ilzarbe M.,
RA Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Streptomyces ghanaensis ATCC 14672.";
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; DS999641; EFE64831.2; -; Genomic_DNA.
DR eggNOG; COG3321; Bacteria.
DR Proteomes; UP000003824; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 2.
DR Gene3D; 3.30.70.3290; -; 2.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 2.
DR Pfam; PF16197; KAsynt_C_assoc; 2.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 2.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00827; PKS_AT; 2.
DR SMART; SM00825; PKS_KS; 2.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 9..429
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 886..961
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 979..1401
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT NON_TER 1869
FT /evidence="ECO:0000313|EMBL:EFE64831.2"
SQ SEQUENCE 1869 AA; 194245 MW; 57F12D60C9017069 CRC64;
MLTRTDPSQA AIAVVGYSCR LPGAPDPDAF WRLLLDGRHA ITEAPADRWT TAQLDAAATP
HAASARWGGF IEHPDAFDAA FFGVSPREAA AMDPQQRLAL ELSWEAVEHA SLLPAALAGT
RTGVFIGAGG DDYATLRRQS AGEITHHTLA GTQRALIANR LSHSLGLRGP SQLVDTGQSS
SLVAVHLACQ SLRSGESVTA LAGGVSLNLA LDTALVAAGV GALSPTGRCH TFDARADGYV
RGEGGGLFLL KLLDRAVADG DTIHAVLLGS AVNHDGDGSA LTVPDVTAQR EVVALAHQAA
GVSPVDVDYV ELHGTGTKVG DPVEAAALGA SIGAARPAGS PLLVGSAKTN VGHLESAAGV
VGLLKTVMAV RHGSIPASLH FHAPPSGIPL DELNLQVATG HRSWRDDRRV AGVSSFGLGG
ANCHVVVAAH VPDVSAAPAP AERTPPSGAV PLVVSGRTPA ARLAQAARLA DWVDDHPGTD
PVDLGGSLLS SRTLFDHRAV SLGTDGLRAL ATGEPGEDVV TGHATTTVGK TVFVFPGQGS
QWVGMARELM DGSPVFAARM DECAQALEPF VDWRLADVLG DADALGRTEV VQPALWAVMV
SLAATWQSLG VVPDAVLGHS QGEVAAAVVA GALSLEDGAR VVALRARTLR ALAGHGGMTS
LALPVREARR FIGPELSIAT VNGPSSVVVA GAPEALAELE ARAEELDVQA RRLPVEYASH
CPQVEEIEQD VLDVLRDVTP RVAGVPLFST VNVDWTDGTE LDARYWYRNL RRTVEFEAAV
RTVADAGYGV FVEVSTHPVL TSAVAGTAGD VITGGTLRRD DGGWERLKRS AAELFVQGVD
VDWSPLLTGA NRVALPTYPF QRQSYWFDRA AEPAPAVTAL ADTGLPALTD LVRSHAAAVL
GHPSADEVDV RLAFKALGLD STSSLELRGR LAAATGLRLP AALVYNHPTV EEVASFLHRA
LHGADTAAPA AAPAAAPADE PVAIVAMSCR LPGGVRSPED LWRLVESGTD AVGPLPEDRG
WDLDTLLGSE GDGTCHTGFG GFLDGVGNFD ADFFGISPRE ALAMDPQQRL LLETSWEVFE
RAGIVPATLR GSATGVFVGA MNQDYLPRLH ELPAEAEGYG LVGGAGSVAS GRISYTFGLH
GPAVTVDTAC SSSLVALHMA ARALRSGECS LALAAGATVM SGPGMLMEFS RQNGLARDGR
CRAFSDDATG TGWGEGVAVL LLERLSDARR NGHPVLALVR GSAVNQDGAS NGLTAPHGPS
QESVVRDALA DARLTAAEVD AVEAHGTGTV LGDPIEAEAL LATYGQDREQ PLWLGSLKSN
IGHTQAAAGI AGVIKTVQAM RHATLPATLH VRTPSSRVDW STGAVRLLTE KAAWPAAARP
RRAGVSSFGV SGTNAHVILE ETPPTESGAA QHAPDAAPAS LPWILTARDA HALHRQADRL
AAHLAAAPQL RPVDVGYSLA AERTAFEERA VLLAGPSGLR PLAEATPGDG LPLPGVVRGT
ALPGARTVFV FPGQGSQWAG MALELAGSAP VFAEQLRACE GALAPYVDWS LSEVLAEPGA
PRLQRVDVVQ PALFAVMVSL AALWRSHGVR PDLVVGHSQG EIAAAVVAGA LSLEDGARVV
ALRSQALRAL AGRGGMVSVA EPEEAAARRL TRWGGRLAIA AVNGPGAVVV SGDPEALDTL
LAACEEEGCR ARRVPVDYAS HSAHVEEIRE AVVGALDGIE PRRAAVPFLS TVTGEVLDGT
GLDAEYWYRN LRGTVRFGPA VADVLSAGSA LFIEVSPHPV LMQGISESVD RTPDHPAAVL
CTLRRDDGGP ERFLTSLAEA YVHGAPVDWT ALYEGSGARR TELPTYPFEP RRYWLDTSRA
AVPARPGPD
//
