ID D6D557_9BACE Unreviewed; 333 AA.
AC D6D557;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Lactate dehydrogenase and related dehydrogenases {ECO:0000313|EMBL:CBK69451.1};
DE EC=1.1.1.28 {ECO:0000313|EMBL:CBK69451.1};
GN ORFNames=BXY_45850 {ECO:0000313|EMBL:CBK69451.1};
OS Bacteroides xylanisolvens XB1A.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=657309 {ECO:0000313|EMBL:CBK69451.1, ECO:0000313|Proteomes:UP000008795};
RN [1] {ECO:0000313|EMBL:CBK69451.1, ECO:0000313|Proteomes:UP000008795}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XB1A {ECO:0000313|EMBL:CBK69451.1,
RC ECO:0000313|Proteomes:UP000008795};
RG metaHIT consortium -- http://www.metahit.eu/;
RA Pajon A., Turner K., Parkhill J., Bernalier A.;
RT "The genome sequence of Bacteriodes xylanisolvens XB1A.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBK69451.1, ECO:0000313|Proteomes:UP000008795}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XB1A {ECO:0000313|EMBL:CBK69451.1,
RC ECO:0000313|Proteomes:UP000008795};
RA Pajon A.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC ECO:0000256|RuleBase:RU003719}.
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DR EMBL; FP929033; CBK69451.1; -; Genomic_DNA.
DR RefSeq; WP_008025799.1; NC_021017.1.
DR AlphaFoldDB; D6D557; -.
DR KEGG; bxy:BXY_45850; -.
DR PATRIC; fig|657309.4.peg.3567; -.
DR eggNOG; COG1052; Bacteria.
DR HOGENOM; CLU_019796_1_1_10; -.
DR Proteomes; UP000008795; Chromosome.
DR GO; GO:0008720; F:D-lactate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR CDD; cd12183; LDH_like_2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43026; 2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED; 1.
DR PANTHER; PTHR43026:SF1; 2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719}.
FT DOMAIN 7..332
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 112..300
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 333 AA; 37260 MW; E302CEBE529B429A CRC64;
MAYTIAFFGT KPYDESSFND KNKEFGFEIR YYKGHLNKNN VLLTQGVDAV CIFVNDVADA
EVIRVMAANG VKLLALRCAG FNNVDLNAAA AAGITVVRVP AYSPYAVAEY TVALMLSLNR
KIPRASWRTK DGNFSLHGLM GFDMHGKTAG IIGTGKIAKI LIHILKGFGM NVLAYDLYPD
YNFARQEQIV YTSLDELYHN SDIISLHCPL TEETKYLIND YSISKMKDGV MIINTGRGQL
IHTNALIEGL KNKKIGSAGL DVYEEESEYF YEDQSDRIID DDVLARLLSF NNVIVTSHQA
FFTHEAMENI AATTLQNIKD FINHKPLLNE VKK
//
