ID D6E6Y2_9ACTN Unreviewed; 732 AA.
AC D6E6Y2;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=GPA_05160 {ECO:0000313|EMBL:CBL03479.1};
OS Gordonibacter pamelaeae 7-10-1-b.
OC Bacteria; Actinomycetota; Coriobacteriia; Eggerthellales; Eggerthellaceae;
OC Gordonibacter.
OX NCBI_TaxID=657308 {ECO:0000313|EMBL:CBL03479.1, ECO:0000313|Proteomes:UP000008805};
RN [1] {ECO:0000313|EMBL:CBL03479.1, ECO:0000313|Proteomes:UP000008805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7-10-1-b {ECO:0000313|Proteomes:UP000008805};
RG metaHIT consortium -- http://www.metahit.eu/;
RA Pajon A., Turner K., Parkhill J., Timmis K., Oxley A., Wurdemann D.;
RT "The genome sequence of Gordonibacter pamelaeae 7-10-1-bT.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBL03479.1, ECO:0000313|Proteomes:UP000008805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7-10-1-b {ECO:0000313|Proteomes:UP000008805};
RA Pajon A.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; FP929047; CBL03479.1; -; Genomic_DNA.
DR AlphaFoldDB; D6E6Y2; -.
DR KEGG; gpa:GPA_05160; -.
DR PATRIC; fig|657308.3.peg.92; -.
DR HOGENOM; CLU_004585_5_5_11; -.
DR BioCyc; GPAM657308:GPA_RS02395-MONOMER; -.
DR Proteomes; UP000008805; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000008805}.
FT DOMAIN 20..307
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 308..576
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 41..48
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 732 AA; 82951 MW; 1771340F48C03D95 CRC64;
MEQMIETAAS DQPDGAGAPP RLNAAQREAV TTTEGYVRVI AGAGTGKTRA LTERFAYLVN
ELGIMPGNVL CATFTNKAAG EMRRRIRRLT GDNDTGYINT FHGFCVSVLQ EDAHALQYPK
SFLVLDNADI DAMLQVVYEE RGLTLRDMTF AKARDMIEIM KLKERPGYYR DMLAMPLEDL
RQKYLDAEAA KDIIFYGYLY QEKKCFGLDY NDLIVFVLYL FEQNPAIRSK WQRRLEYVMV
DEFQDIDGLQ HELMEVLAGY HKNLFVVGDP DQTIYTWRGA DVRYLLDFDK RFPKTHTVMM
LENYRSAPRV VAVANSLIEK NRERMPKRLV AARLAHGPTV WHHAKSAADE ADWIAQGALA
LHVEGVAFRD MAVLYRAHYA SRPVEEALLR AEVPHAVHSG VPFFGRREIK DALSYLRLVA
YRDDLDFARV ANVPKRNLGQ RRMAFLRQQA DERGCSLYEA LALAADDDLF KRTKARQLLD
LIERFHSSYE GRPVSEVLAA VLSESGYERA LRTEGSQERL DNLAELKQSV YEFETTCGEE
VTLEHYLAHV ALFSNADAMD DAQDKVRLMT VHAAKGLEFR HVFLCSMSEG VLPSRKTSTP
QGMEEERRLA FVAMTRARDG LYLTEAEGRS HEGAARYPSR FLLDIDPAAL EFSDKPSDPQ
MADARSVYAL TDRWIADLVR DARFSVGDRV VHAVFGAGRV SAVDTGKRAY EVEFDGMDTP
RTISFKAKLE EA
//
