ID   D6GPN8_FILAD            Unreviewed;       764 AA.
AC   D6GPN8;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   SubName: Full=NlpC/P60 family protein {ECO:0000313|EMBL:EFE28741.1};
GN   OrderedLocusNames=HMPREF0389_00660 {ECO:0000313|EMBL:EFE28741.1};
OS   Filifactor alocis (strain ATCC 35896 / CCUG 47790 / D40 B5) (Fusobacterium
OS   alocis).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Filifactor.
OX   NCBI_TaxID=546269 {ECO:0000313|EMBL:EFE28741.1, ECO:0000313|Proteomes:UP000007468};
RN   [1] {ECO:0000313|Proteomes:UP000007468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35896 / D40 B5 {ECO:0000313|Proteomes:UP000007468};
RG   The Broad Institute Genome Sequencing Platform;
RA   Ward D., Earl A., Feldgarden M., Young S.K., Gargeya S., Zeng Q.,
RA   Alvarado L., Berlin A., Bochicchio J., Chapman S.B., Chen Z., Freedman E.,
RA   Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA   Howarth C., Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., White J., Yandava C., Izard J.,
RA   Blanton J.M., Baranova O.V., Tanner A.C., Dewhirst F.E., Haas B.,
RA   Nusbaum C., Birren B.;
RT   "The genome sequence of Filifactor alocis strain ATCC 35896.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase C40 family.
CC       {ECO:0000256|ARBA:ARBA00007074}.
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DR   EMBL; CP002390; EFE28741.1; -; Genomic_DNA.
DR   RefSeq; WP_000412442.1; NC_016630.1.
DR   AlphaFoldDB; D6GPN8; -.
DR   STRING; 546269.HMPREF0389_00660; -.
DR   KEGG; faa:HMPREF0389_00660; -.
DR   PATRIC; fig|546269.5.peg.1140; -.
DR   eggNOG; COG0791; Bacteria.
DR   OrthoDB; 9812962at2; -.
DR   Proteomes; UP000007468; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.1720.10; endopeptidase domain like (from Nostoc punctiforme); 1.
DR   InterPro; IPR000064; NLP_P60_dom.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   PANTHER; PTHR47053; MUREIN DD-ENDOPEPTIDASE MEPH-RELATED; 1.
DR   PANTHER; PTHR47053:SF1; MUREIN DD-ENDOPEPTIDASE MEPH-RELATED; 1.
DR   Pfam; PF00877; NLPC_P60; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS51935; NLPC_P60; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007468};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        413..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          639..764
FT                   /note="NlpC/P60"
FT                   /evidence="ECO:0000259|PROSITE:PS51935"
FT   REGION          52..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          209..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..101
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        229..272
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   764 AA;  87542 MW;  9E0A5BAF7FCBF007 CRC64;
     MEKKLRRDFK ERQKIKEEAK LLGKEYMDAD EAGKLKHGDD YRGKIIHEKD RFQDKIHEKE
     SKRNSKNELL QGSSKRKVKQ LKNVVKDKET DTSKEDNKSP LVSGDENSVF TSLANDETIA
     DEIVSAPKSI KTEKEISFEE QKAELLKKRK MAEKVRKELR TEGKYSQNEE IYDPLGKDLD
     NDGIIDRYDN DFRDSDYFES TYDVEDNLHT KEGITEHSNK KHNAQKKLYK RKNYSDKVYT
     RKKEDNHADD KTEGKKSSKE MIQGREKKKS AKGSVLSGLA KGSEAVRDYL SHGSDENQGV
     ETGEKIADGN SKLLHGIKNY ADKKKAKKSY NLSKKDYKIR KRKSKLEFRE AKEELKKTKE
     YKQANAFKKF QKKKQMKSAI GKRNKSRLRD RIKESLIGTL KSSKEMLIRK AKGLMMIVIG
     LIILGTFIIQ FAGTSMTGMI NSTSGVLTTT YLSDQNVLSE INQQFSGLEE GLQDEISSVE
     ENYPGYDEYL IEKEGEIGHN THELLSYITS RCGEIKDSKE VQSIIHDIFT KMYDLSYREE
     IEIRYRTVTE TYTDEDGNEH TESHEEAYEY KKLIVTLKKR EMDSIVREIF AEYPDNVLHY
     EALLASKGNM ETVFGSGNGN LSEIVDNPDF SNPGIAFDDV TVKALFNEAE KHIGKRYVFG
     ANGPNNFDCS SFVCWSFTHS GVKNMPRTTA WGIYKTYCNP VSPSEAKAGD IIFFKNTYDS
     GSPISHVGIY AGNGMMIHAG DPIRFVSINT PYWREHFYGF GRVK
//