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Database: UniProt
Entry: D6K441_9ACTN
LinkDB: D6K441_9ACTN
Original site: D6K441_9ACTN 
ID   D6K441_9ACTN            Unreviewed;      1524 AA.
AC   D6K441;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   28-FEB-2018, entry version 40.
DE   SubName: Full=Modular polyketide synthase {ECO:0000313|EMBL:EFF93633.2};
DE   Flags: Fragment;
GN   ORFNames=SSTG_03952 {ECO:0000313|EMBL:EFF93633.2};
OS   Streptomyces sp. e14.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=645465 {ECO:0000313|EMBL:EFF93633.2, ECO:0000313|Proteomes:UP000004704};
RN   [1] {ECO:0000313|EMBL:EFF93633.2, ECO:0000313|Proteomes:UP000004704}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=e14 {ECO:0000313|Proteomes:UP000004704};
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Microbial Sequencing Center;
RA   Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA   Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C.,
RA   Sykes S.N., Thomson T., Walk T., White J., Yandava C., Straight P.,
RA   Clardy J., Hung D., Kolter R., Mekalanos J., Walker S., Walsh C.T.,
RA   Wieland-Brown L.C., Haas B., Nusbaum C., Birren B.;
RT   "The genome sequence of Streptomyces sp. strain e14.";
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GG753626; EFF93633.2; -; Genomic_DNA.
DR   ProteinModelPortal; D6K441; -.
DR   STRING; 645465.SSTG_03952; -.
DR   EnsemblBacteria; EFF93633; EFF93633; SSTG_03952.
DR   eggNOG; COG3321; LUCA.
DR   OrthoDB; POG091H06Z6; -.
DR   Proteomes; UP000004704; Unassembled WGS sequence.
DR   GO; GO:0048037; F:cofactor binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.366.10; -; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR032821; KAsynt_C_assoc.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020801; PKS_acyl_transferase.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR020807; PKS_dehydratase.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR015083; Polyketide_synth_docking.
DR   InterPro; IPR036299; Polyketide_synth_docking_sf.
DR   InterPro; IPR016039; Thiolase-like.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF08990; Docking; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF14765; PS-DH; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF101173; SSF101173; 1.
DR   SUPFAM; SSF51735; SSF51735; 2.
DR   SUPFAM; SSF52151; SSF52151; 2.
DR   SUPFAM; SSF53901; SSF53901; 1.
DR   SUPFAM; SSF55048; SSF55048; 1.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004704};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004704}.
FT   DOMAIN       77    501       PKS_KS. {ECO:0000259|SMART:SM00825}.
FT   DOMAIN      600    900       PKS_AT. {ECO:0000259|SMART:SM00827}.
FT   DOMAIN      965   1132       PKS_DH. {ECO:0000259|SMART:SM00826}.
FT   COILED       52     72       {ECO:0000256|SAM:Coils}.
FT   NON_TER    1524   1524       {ECO:0000313|EMBL:EFF93633.2}.
SQ   SEQUENCE   1524 AA;  159153 MW;  22F10844297D6E5D CRC64;
     MPSPQPSHPL TSPEGTDRAM PNEPTSTAGS PRQSAAPGSP GAAGEQKLRD YLKRALVDLQ
     QANKRLHDIE AARSEPIAIV GMACRLPGGV STPDELWELV AEGRDAVSGF PDNRGWDLER
     LFDADPERPG TSYVREGGFL HDADRFDAAF FGINQREALS MNPQQRLLLE TSWETFERAG
     IDPTKLRGRR VGVYTGVMYH DYGADMENAP PEVEGYLSTG TAGAVASGRI AYTLGLEGPA
     VTLDTACSSS LVALHLAIQA LRDGEIDMAL TGGAAVMASP GVFVEFSRQR ALSPDGRCKA
     YAEAADGTGW AEGVATILVE RLSDARRSGH PVLAVVRGSA INQDGASNGL TAPSGPAQQR
     VIRQALANAG VSADGVDVVE GHGTGTTLGD PIEAQALLAT YGRDREVPLW LGSLKSNIGH
     AQSAAGVAGI IKMVQAMRHG VLPRTLHVDQ PSTKVDWGSG AVELLTQARA WPEVERPRRA
     AVSSFGVSGT NAHVILEQAP DQPEPEAGPR PPAIPWRVSA RTGAALRAQA RRLLTATDGL
     EPVAVAQTLS RARSAFTERA VVVGGEGGEL SLGLRALADG VPSPFVVTGS ADVEGGTVFV
     FPGQGHQWAG MGARLLESEP VFAGALAECA RALSAYVEWD LLDVVRQAEG APGFDRVDVV
     QPASFAVMVA LARLWQHYGV RPDAVVGHSQ GEIAAAHVAG ALSLEDAVRV VALRSQAIGG
     RLAGRGGMMF LPVSRAEAEE RIAAYAGRVE VAAVNGPAST VVAGDAGALK ELFEAATGAG
     VRARMVPVDY ASHTVHVEAI EDELAQVLAG LVPRAPEIPM YSTFRDAWLD GSTVLDASYW
     YGNLRHEVRF ASAVEALAGA GYRAFVEVSA HPVLTTAVQD LLDAHADSPA VTTGTLRRDE
     DTSARFHMSL ATLHTRGIAT DPLPDVTGHR HVDLPTYPFQ HQSYWLQIPE SAGDLGTAGL
     DDAGHPLLGA VVRLPEDGGV LLTGRLSLAS HPWLADHAVS GTVLVPGAAL VELAVHAGQQ
     VDAGVLDELV VETPLVLPAT GAVRVQVTAG ATDDLGRRAV AVHARGEDGE AWTRHASGFL
     TTGVAGHGTG SAADGFDFGV WPPEGAEALS VADFYDLRFV AGYEYGPVFQ GLRRVWRRGE
     ELFADVVLGE EAAGDAGAFG LHPALLDAAL HTAAFADGPQ DERTLLPFAW NGVAVHATGV
     SALRVRIAPR GADAVSVQAA DGAGSPVATV GSLAFRAVDP RQLESGDDVL RDALFRVDWQ
     EVPAPETSAG ADWPVLDLTG RPGADVRELA GEALAAVQAY LAREAEGSRL VVLTRDAVAD
     PAQAAVWGLV RTAQNEHPDR LVLVDVADGS ESLLPAALAS GEPQLALAGD VIRVPRLVRA
     ETAEATGVSM LDPDGTVLIT GGTGTLGALA ARHVVTAHGI RRLLLLSRRG PDAPGAGDLT
     RELSELGAHV TVVAADAADR DQLAAALAAV DPEHPLTAVV HTAGALRDGV ITAQTPHHLD
     AVFAPKTDAA RHLHELTKDQ DLAA
//
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